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个人简介

1979-1983年 北京医科大学 化学专业;毕业后留校任教,从事药物化学相关的教学和科研工作;1994年 在北医大提为副教授;1997年开始从事细胞水平药物筛选研究;2000-2002年 在北京大学医学部干细胞研究中心任副教授;2002-2005 在哈佛大学(化学与生物学研究所)和布朗迪斯大学(生物分析中心)作访问学者;2005年回国,同年11月,由 “985”二期平台聘任为研究员、博士生导师,进入放射性药物教育部重点实验室工作。

研究领域

1. 干细胞药物的筛选研究   干细胞药物是指可以调节干细胞的增殖与分化,来防治由于细胞缺失或损伤而引起的疾病的一类治疗及预防药物。由于干细胞具有自我更新能力和多向分化潜能,对许多细胞缺失或损伤性疾病如:神经损伤或退行性疾病、血液系统疾病、心脏病、糖尿病等具有细胞替代治疗价值,但干细胞在体内数量很少,很难分离和培养。用小分子化合物,特别是天然小分子化合物(中药成分)作为干细胞药物来促进干细胞增殖与分化,有望解决细胞和组织替代治疗中干细胞来源以及调控等难题,拥有广阔的临床应用前景。   我们实验室的研究兴趣是:运用化学生物学的跨学科研究方法,构建干细胞药物筛选平台,寻找具有促进干细胞增殖作用的小分子药物(包括合成小分子化合物和中药来源的天然小分子化合物),特别是神经干细胞药物;研究其生物学作用的量效关系和构效关系;探索其对干细胞增殖调控的作用机制;以及作为干细胞药物在细胞缺失或损伤性疾病治疗中可能的药用价值。 2. 放射性药物化学研究   实验室的研究兴趣还包括放射性药物化学的跨学科应用研究: 运用放射性药物的标记示踪技术,研究药物的吸收、分布、代谢和毒性;运用SPECT、 PET分子影像学技术,研究药物的作用机理、评价药物的疗效以及治疗的预后。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

论著(第一主编) 韩 梅, 乔晋萍, 出版教材《医学营养学基础》(29万字),2011年1月中国医药科技出版社出版,书号:ISBN978-7-5067-4779-0。 论文(第一作者或通信作者) Yingqian Ci, Yubo Zhang, Yanjie Liu, Shuai Lu, Jianhua Cao, Huajun Li, Jing Zhang, Zongyu Huang, Xudong Zhu, Jin Gao, Mei Han*. Myricetin suppresses breast cancer metastasis through down-regulating the activity of matrix metalloproteinase (MMP)-2/9. Phytotherapy Research. 2018,32:1373–1381. Shasha Xu, Shaoang Tu, Jinlong Gao, Jia Liu, Zhirui Guo, Jinming Zhang, Xingdang Liu, Jianhui Liang*, Yiyun Huang*, Mei Han*. Protective and restorative effects of the traditional Chinese medicine Jitai tablet against methamphetamine-induced dopaminergic neurotoxicity. BMC Complementary and Alternative Medicine. 2018,18(1):76. Ying Sun, Xiaoyan Zhang, Huajun Li, Shasha Xu, Xiaoyan Zhang, Yinan Liu, Mei Han*, Jinhua Wen. Stemazole Promotes Survival and Preserves Stemness in Human Embryonic Stem Cells. Febs Journal. 2018,285(3):531-541. Shasha Xu, Ying Liu, Yu Li, Yangping Deng, Jie Yuan, Rongbin Lv, Yuankai Wang, Guangming Zhang, Zhirui Guo, Daxu Fu, Hui Zeng, Xingdang Liu*, Mei Han*. Availability of dopamine transporters in heroin-dependent subjects: A 18F-FECNT PET imaging study. Psychiatry Research: Neuroimaging. 2017,263:121-126. Yingqian Ci, Jinping Qiao* and Mei Han*. Molecular Mechanisms and Metabolomics of Natural Polyphenols Interfering with Breast Cancer Metastasis. Molecules. 2016,21(12):1634. Jianhua Cao, Jie Han, Hao Xiao, Jinping Qiao* and Mei Han*. Effect of Tea Polyphenol Compounds on Anticancer Drugs in Terms of Anti-Tumor Activity, Toxicology, and Pharmacokinetics. Nutrients. 2016,8(12):762. Zhirui Guo, Shasha Xu, Na Du, Jia Liu, Yiyun Huang, Mei Han*. Neuroprotective effects of stemazole in the MPTP-induced acute model of Parkinson's disease: Involvement of the dopamine system. Neuroscience Letters. 2016,616:152-159. Shasha Xu, Ying Liu, Yu Li, Yangping Deng, Yiyun Huang, Jie Yuan, Rongbin Lv, Yuankai Wang, Guangming Zhang, Zhirui Guo, Mei Han*, Xingdang Liu*, Daxu Fu*. Longitudinal changes of dopamine transporters in heroin users during abstinence. Psychopharmacology. 2015, 232(18):3391-3401. Jie Yuan, Xing Dang Liu*, Mei Han*, Rong Bin Lv, Yuan Kai Wang, Guang Ming Zhang &Yu Li. Comparison of striatal dopamine transporter levels in chronic heroin-dependent and methamphetamine-dependent subjects. Addiction Biology. 2015,22(1): 229-234. Shaoang Tu, Jinlong Gao, Jia Liu, Jinming Zhang, Yiyun Huang, Shasha Xu, Mei Han* and Jianhui Liang*. Effects of Jitai Tablet, A Traditional Chinese Medicine, on Spontaneous Withdrawal Symptoms and Modulation of Dopaminergic Functions in Morphine-Dependent Rats. Phytotherapy Research. 2015.29(5):687-94. Weihu Shang, Xiaoyan Zhang, Mo Zhang, Zetan Fan, Ying Sun, Mei Han*and Louzhen Fan*. The uptake mechanism and biocompatibility of graphene quantum dots with human neural stem cells. Nanoscale. 2014,6(11):5799-5806. Jinping Qiao, Xiangyi Kong, Aiying Kong, Mei Han*. Pharmacokinetics and Biotransformation of Tea Polyphenols. Current Drug Metabolism. 2014.15(1):30-36. Weihu Shang, Jinping Qiao, Weidong Lu, Mei Han*. The interactions of anticancer agents with tea catechins: current evidence from preclinical studies. Anti-cancer agents in medicinal chemistry. 2014.14(10):1343-1350. Jia Liu, Jinlong Gao, Shaoang Tu, Shasha Xu, Ying Liu, Weihu Shang, Chenxin Gu, Yiyun Huang, and Mei Han*. Neuroprotective Effects of Jitai Tablet,a Tradtional Chinese Medicine ,on the MPTP-Induced Acute Model of Parkinson's Disease: Involvement of the Dopamine System. Evidence-Based Complementary and Alternative Medicine. 2014, Article ID 542383, 9 pages. Jin-Long Gao, Shao-Ang Tu, Jia Liu, Jin-Ming Zhang, Yiyun Huang, Mei Han* and Jian-Hui Liang. An-jun-ning, a traditional herbal formula, attenuates spontaneous withdrawal symptoms via modulation of the dopamine system in morphine-dependent rats. BMC Complementary and Alternative Medicine. 2014,14(1):308. Jie Yuan, Rongbin Lv, James Robert Bra?i?, Mei Han, Xingdang Liu, Yuankai Wang, Guangming Zhang, Congjin Liu, Yu Li, Yanping Deng. Dopamine transporter dysfunction in Han Chinese people with chronic methamphetamine dependence after a short-term abstinence. Psychiatry Research: Neuroimaging. 2014,221(1):92-96. Ying Liu, Mei Han, Xingdang Liu , Yan ping Deng, Yu Li, Jie Yuan, Rongbin Lv, Yuankai Wang, Guangming Zhang, Jinlong Gao. Dopamine transporter availability in heroin-dependent subjects and controls: longitudinal changes during abstinence and the effects of Jitai tablets treatment. Psychopharmacology. 2013,230(2):235-244. Chenxin Gu, Jinping Qiao, Meilin Zhu, Jinglei Du, Weihu Shang,Wei Yin, Wei Wang, Mei Han*, and Weidong Lu. Preliminary Evaluation of the Interactions of Panax ginseng and Salvia miltiorrhiza Bunge with 5-Fluorouracil on Pharmacokinetics in Rats and Pharmacodynamics in Human Cells. The American Journal of Chinese Medicine. 2013,41(2):443-458. Mo Zhang, Linling Bai, Weihu Shang, Wenjing Xie, Hong Ma, Yingyi Fu, Decai Fang, Hui Sun, Louzhen Fan*, Mei Han*, Chenmin Liu, and Shihe Yang*. Facile synthesis of water-soluble, highly fluorescent graphene quantum dots as a robust biological label for stem cells. Journal of Materials Chemistry. Journal of Materials Chemistry. 2012,22(15):7451-7467. Yifeng E, Linling Bai, Louzhen Fan*, Mei Han*, Xiaoyan Zhang and Shihe Yang*,Electrochemically generated fluorescent fullerene[60] nanoparticles as a new and viable bioimaging platform. Journal of Materials Chemistry. 2011,21:819-823. Jinping Qiao, Chenxin Gu, Weihu Shang, Jinglei Du, Wei Yin, Meiling Zhu, Wei Wang, Mei Han*, Weidong Lu*,Effect of green tea on pharmacokinetics of 5-fluorouracil in rats and pharmacodynamics in human cell lines in vitro. Food and Chemical Toxicology. 2011,49: 1410-1415. Ying Sun, Wei Wang, Yuanyuan Sun, Mei Han*, Synthesis and biological evaluation of a novel human stem/progenitor cells proliferation activator: (5-mercapto-1,3,4- oxadiazol-2-yl) phenyl thiosemicarbazide (Stemazole). European Journal of Medicinal Chemistry. 2011,46:2930-2936. Mei Han*, Ying Liu, Qi Tan , Bing Zhang, Wei Wang, Jian Liu, Xiao-Jun Zhang, Yong-Yan Wang Jin-Ming Zhang*, Therapeutic efficacy of stemazole in a beta-amyloid injection rat model of Alzheimer's disease. European Journal of Pharmacology. 2011,657:104-110. Weihu Shang,Jinping Qiao,Chenxin Gu, Wei Yin, Jinglei Du, Wei Wang, Meilin Zhu, Mei Han*, Weidong Lu**, Anticancer activity of an extract from needles and twigs of Taxus cuspidata and its synergistic effect as a cocktail with 5-fluorouracil. BMC Complementary and Alternative Medicine. 2011,11(1):123. Mei Han*, Ying Liu, Bing Zhang, Jinping Qiao, Weidong Lu, Yanyan Zhu, Yongyan Wang, Changqi Zhao*, Salvianic borneol ester reduces beta-amyloid oligomers and prevents cytotoxicity. Pharmaceutical Biology. 2011,49(10):1008-1013. Mei Han*, JinFeng Li, Qi Tan, Yuanyuan Sun, Yongyan Wang,Limitation of the use of MTT assay for screening in drug-discovery. Journal of Chinese Pharmaceutical Sciences. 2010,19 (2):195-200. 韩 梅*,乔晋萍,孙媛媛,谭祺,张冰,王永炎,朱霖, 应用在药物滥用研究中的SPECT和PET分子显像剂的研究进展, 中国药物依赖性杂志. 2009,18(1):2-6 (CSTPCD) 韩 梅*,张文生,李金凤,孙媛媛,朱有惠,王永炎, 神经退行性或损伤性疾病防治的新视点--干细胞药物, 中国药理学通报(国内药学类期刊影响因子排名第一)2008, 24(7):421-424(CSTPCD)

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