卢忠林 - 北京师范大学

个人简介

学历及所获学位 1997.07 南京大学，理学博士（导师:游效曾院士） 1993.07 兰州大学，理学硕士（导师:马永祥教授） 1990.07 兰州大学，理学学士工作经历 1996年4月至12月香港大学化学系 Andreas Mayr 教授组做研究助理。1997年至1999年在中山大学物理化学研究所康北笙教授组做博士后。1999年至2003年在德国埃尔朗根-纽伦堡大学( The University of Erlangen-Nuernberg )无机化学研究所Rudi van Eldik 教授组和蒂宾根大学( The University of Tuebingen )无机化学研究所 Ekkehard Lindner 教授组做洪堡学者。2003.06-2006.11在瑞士巴塞尔大学( The University of Basel )化学系 Andreas Pfaltz 教授和加拿大皇后大学( Queen’s University )化学系 R. Stan Brown 教授组做博士后。2006年12月应聘为北京师范大学化学学院有机化学研究所教授。2007年6月评为博士生导师。2008年入选教育部“新世纪优秀人才支持计划”，2015年获得宝钢教育基金会优秀教师奖，2017年获得北京市高等学校教学名师奖。2020年获得北京师范大学“四有”好老师金质奖章,“最受本科生欢迎的十佳教师”，获批主持国家级一流本科课程建设项目(有机化学-线下课程)。目前担任化学学院党委书记社会工作中国化学会理事、高级会员；《化学教育》编委；北京市青少年科技俱乐部指导教师；美国化学会会员；英国皇家化学会会员；中国科协英才计划指导教师

研究领域

化学生物学有机小分子非病毒基因载体和荧光探针的设计合成及性能研究药物缓释体系的设计及性能研究生物活性小分子荧光探针设计合成及性能研究超分子化学分子拉链的设计合成及肽的折叠组装研究刚性大环的设计合成及其可控自组装应用开发工业废水处理，药物中间体研制

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Sun, X.-Y.; Zhong, Y.; Li, Y.-H.; Miller, D. P.; Buttan, S.; Wu, X.-X.; Zhang, Y.; Tang, Q.; Tan, H.-W.; Zhu, J.; Liu, R.; Zurek, E.; Lu, Z.-L.*; Gong, B.* Reliable folding of hybrid tetrapeptides into short β-hairpins. Chin. Chem. Lett. 2021, Ahead of Print. Liu, X.-Y.; Yang, J.-B.; Duan, T.-T.; Wu, C.-Y.; Tang, Q.; Lu, Z.-L.*; He, L.*; Sun, W.* Degradable cationic polyesters via ring-opening copolymerization of valerolactones as nanocarriers for the gene delivery. Biorg. Chem. 2021, 116, 105299. Liu, M.-X.; Liu, X.-Y.; Liu, J.-Y.; Tang, J.-T.; Shi, K.; Mao, J.; Lu, Z.-L.*; Qiao, H.-J.*; He, L.* Di[12]aneN3-functionalized green fluorescent protein chromophore for GFP luminescence simulation and efficient gene transfection in vitro and in vivo. ACS Appl. Bio. Mater. 2021, 4(9), 7111-7112. Tang, F.; Liu, J.-Y.; Wu, C.-Y.; Liang, Y.-X.; Lu, Z.-L.*; Ding, A.-X.*; Xu, M.-D.* Two-photon near-infrared AIE luminogens as multifunctional gene carriers for cancer theranostics. ACS Appl. Mater. Interf. 2021, 13, 23384-23395. Tang, F.; Gao, C.; Liu, J.-Y.; Lu, Z.-L.*; He, L.*; Ding, A.-X.* Lysosome-targeting BODIPY-derived Hantzsch ester for nitric oxide detection and imaging in live cells. Sens. & Actu., B: Chem. 2021, 339, 129880. Sun, X.-Y.; Liang, Y.-X.; Wu, C.-Y.; Tang, Q.; Liu, R.*; Lu, Z.-L.*; He, L.* Nitroreductase-responsive polymeric micelles based on 4-nitrobenzyl and AIE moieties for intracellular doxorubicin release. Poly. Chem. 2021, 12, 2618-2626. Liu, J.-Y.; Sun, X.-Y.; Tang, Q.; Song, J.-J.; Li, X.-Q.; Gong, B.; Liu, R.*; Lu, Z.-L.* An unnatural tripeptide structure containing intramolecular double H-bonds mimics a turn hairpin conformation. Org. Biomol. Chem. 2021, 19, 4359-4363. Liu, J.-Y.; Liu, X.-Y.; Liu, R.; Tang, F.; Yang, J.-B.; Tang, Q.; Lu, Z.-L.*; Qiao, H.-J.*; He, L.* Integration of [12]aneN3 and Acenaphtho[1,2-b]quinoxaline as non-viral gene vectors with two-photon property for enhanced DNA/siRNA delivery and bioimaging. Bioorg. Chem. 2021, 113, 104983. Zhong, Y. L.; Tang, Q.; Miller, D. P.; Zurek, E.; Liu, R.; Lu, Z.-L.*; Gong, B.* Major factors for the persistent folding of hybrid α, β, γ-hybrid peptides into hairpins. Front. Chem. 2020, 8, 530083. Zhong, Y.; Kauffmann, B.; Xu, W.; Lu, Z.-L.; Ferrand, Y.; Huc, I.; Zeng, X. C.; Liu, R.*; Gong, B.* Multiturn Hollow Helices: Synthesis and Folding of Long Aromatic Oligoamides. Org. Lett. 2020, 22, 6938-6942. Sun, W.; Tang, F.; Cui, J.-X.; Lu, Z.-L.* Fluorescent Nanoparticles for Targeted Tumor Imaging and DNA Tracking Gene Delivery In Vitro/In Vivo. ACS Omega 2020, 5, 31700-31705. Ma, L.-L.; Tang, Q.; Liu, M.-X.; Liu, X.-Y.; Liu, J.-Y.; Lu, Z.-L.; Gao, Y.-G.; Wang, R.aneN3-Based Gemini-Type Amphiphiles with Two-Photon Absorption Properties for Enhanced Nonviral Gene Delivery and Bioimaging. ACS Appl. Mater. Interf. 2020, 12, 40094-40107. Ma, L.-L.; Liu, M.-X.; Liu, X.-Y.; Sun, W.; Lu, Z.-L.*; Gao Y. G.*; He, L.* Macrocyclic polyamine [12]aneN3 modified triphenylamine-pyrazine derivatives as efficient non-viral gene vectors with AIE and two-photon imaging properties. J. Mater. Chem. B, 2020, 8, 3069-3079. Sun, W.; Liu, X.-Y.; Ma, L.-L.; Lu, Z.-L.* Tumor targeting gene vector for visual tracking of Bcl-2 siRNA transfection and anti-tumor therapy. ACS Appl. Mater. Interfaces 2020, 12, 10193-10201. Wang, Q.-H; Zhong, Y.-L.; Miller, D. P.; Lu, X.-L.; Tang, Q.; Lu, Z. -L.; Zurek, E.; Gong, B.*; Liu, R.* Self-assembly and molecular recognition in water: Tubular stacking and guest-templated discrete assembly of water-soluble, shape- persistent macrocycles. J. Am. Chem. Soc., 2020, 142，2915-2924. Tang, Q.; Zhong, Y. -L.; Miller, D. P.; Liu, R.; Zurek, E.; Lu, Z-L.*; Gong, B.* Reverse turn foldamers: An expanded β-turn motif reinforced by double hydrogen bonds. Org. Lett., 2020, 22， 1003-1007. Gao, Y.-G.; Huangfu, S.-Y.; Patil, S.; Tang, Q.; Sun, W.; Li, Y.; Lu, Z.-L.*; Qian, A.R.* [12]aneN3-Based multifunctional compounds as fluorescent probes and nucleic acids delivering agents. Drug Delivery, 2020, 27, 66-80. Liu, M.-X.; Ma, L.-L.; Liu, X.-Y.; Liu, J.-Y.; Lu, Z.-L.*; Liu, R.; He, L.* Combination of [12]aneN3 and triphenylamine-benzylideneimidazolone as nonviral gene vectors with two-photon and AIE properties. ACS Appl. Mater. Interfaces 2019, 11, 42975-42987. Li, Y.-Q.; Sun, W.; Liu, X.-Y.; Chen, L.-Q.; Huang, W.; Lu, Z.-L.*; He, L. Synthesis of glutathione (GSH)-responsive amphiphilic duplexes and their application in gene delivery. ChemPlusChem, 2019, 84, 1060-1069. Zhang, Y.K.; Zhong, Y.L.; Connor, A. L.; Miller, D. P.; Cao, R.K.; Shen, J; Song, B.; Baker, E. S.; Tang, Q.; Pulavarti, S. V. S. R. K.; Liu, R.; Wang, Q.W.; Lu, Z.-L.; Szyperski, T.; Zeng, H.Q.; Li, X.P.; Smith, R. D.; Zurek, E.; Zhu, J.*; Gong, B.* Folding and assembly of short α, β, γ-hybrid peptides: Minor variations in sequence and drastic differences in higher-level structures. J. Am. Chem. Soc. 2019, 141, 14239-14248. Gao, Y.-G; Liu, F.-L; Lu, F.-H; Uzair A.; Tang, Q.; Huang, J.-W.; Lu, Z.-L.*,aneN3-Based single aliphatic chain modified cationic lipids as gene delivery vectors. Tetrahedron, 2019, 75, 658-664. Sun, W.; Liu, X.-Y.; Cui, J.-X.; Ma, L.-L.; Zhang, Y.; Lu, Z.-L.*; He, L.*, Mitochondria targeting two-photon fluorescent molecules for gene transfection and biological tracking. J. Mater. Chem. B, 2019, 7, 4309-4318. Dai, Y.-D.; Sun, X.-Y.; Sun, W.; Yang, J.-B.; Liu, R.*; Luo, Y.; Zhang, T.; Tian, Y.; Lu, Z.-L.*; He, L.*, H2O2-Responsive polymeric micelles with a benzil moiety for efficient DOX delivery and AIE imagin. Org. Biomol. Chem., 2019, 17, 5570-5577. Sun, W.; Cui, J.-X.; Ma, L.-L.; Lu, Z.-L.*; Gong, B.; He L.*; Wang, R.*, Imaging nucleus viscosity and G-quadruplex DNA in living cells using a nucleus-targeting two-photon fluorescent probe. Analyst, 2018, 143, 5799-5804. Sun, W.; Shi, Y.-D.; Ding, A.-X.; Tan, Z.-L.; Chen, H.; Liu, R.*; Wang, R.; Lu, Z.-L.*, Imaging viscosity and peroxynitrite by a mitochondria-targeting two-photon ratiometric fluorescent probe. Sensors and Actuators, B: Chem., 2018, 276, 238-246. Gao, Y.-G.; Alam, U.; Ding, A.-X.; Tang, Q.; Tan, Z.-L.; Shi, Y.-D.; Lu, Z.-L.*; Qian, A.-R.*, [12]aneN3-Based lipid with naphthalimide moiety for enhanced gene transfection efficiency. Bioorg. Chem. 2018, 79, 334-340. Ai, W.; Liu, Y.; Wang, Q.; Lu, Z.-L.*; Liu, Q.*, Cu-Catalyzed redox-neutral ring cleavage of cycloketone O-acyl oximes: Chemodivergent access to distal oxygenated nitriles. Org. Lett. 2018, 20 (2), 409-412. Shi, Y.-D.; Tang, Q.; Jiang, Y.-F.; Pei, Q.; Tan, H.-W.; Lu, Z.-L.*; Gong, B.*, Effective formation of stable and versatile double-stranded β-sheets templated by a hydrogen-bonded duplex. Chem. Comm. 2018, 54 (30), 3719-3722. Ding, A.-X.; Shi, Y.-D.; Zhang, K.-X.; Sun, W.; Tan, Z.-L.; Lu, Z.-L.*; He, L.*, Self-assembled aggregation-induced emission micelle (AIE micelle) as interfacial fluorescence probe for sequential recognition of Cu2+ and ATP in water. Sensors and Actuators, B: Chem. 2018, 255 (Part_1), 440-447. Gao, C.; Lin, L.*; Sun, W.; Tan, Z.-L.; Huang, J.-R.; He, L.*; Lu, Z.-L.*, Dihydropyridine- derived BODIPY probe for detecting exogenous and endogenous nitric oxide in mitochondria. Talanta 2018, 176, 382-388. Zhang, K.-X.; Ding, A.-X.; Tan, Z.-L.; Shi, Y.-D.; Lu, Z.-L.*; He, L.*, Tetraphenylethylene-based gemini surfactant as nonviral gene delivery system: DNA complexation, gene transfection and cellular tracking. J. Photochem. Photobiol., A: Chem. 2018, 355,338-349. Zhong, Y.; Yang, Y.; Shen, Y.; Xu, W.; Wang, Q.; Connor, A. L.; Zhou, X.; He, L.; Zeng, X. C.; Shao, Z.; Lu, Z.-L.; Gong, B., Enforced tubular assembly of electronically different hexakis(m-phenylene ethynylene) macrocycles: Persistent columnar stacking driven by multiple hydrogen-bonding interactions. J. Am. Chem. Soc. 2017, 139 (44), 15950-15957. Song, L.; Ding, A.-X.; Zhang, K.-X.; Gong, B.; Lu, Z.-L.*; He, L.*, Degradable polyesters via ring-opening polymerization of functional valerolactones for efficient gene delivery. Org. Biomol. Chem. 2017, 15, 6567-6574 Pei, Q.; Tang, Q.; Tan, Z.-L.; Lu, Z.-L.*; He, L.*; Gong, B., Amphiphilic oligoamides as versatile, acid-responsive gelators. RSC Advances 2017, 7, 22248-22255. Li, Z.-H.; Liu, R.; Tan, Z.-l.; He, L.; Lu, Z.-L.*; Gong, B.*, Aromatization of 9,10- dihydro-acridine derivatives: Discovering a highly selective and rapid- responding fluorescent probe for peroxynitrite. ACS Sensors 2017, 2, 501-505. Hu, T.; Connor, A. L.; Miller, D. P.; Wang, X.; Pei, Q.; Liu, R.; He, L.; Zheng, C.; Zurek, E.; Lu, Z.-L.*; Gong, B.*, Helical folding of meta-connected aromatic oligoureas. Org. Lett. 2017, 19, 2666-2669. Ding, A.-X.; Tan, Z.-L.; Shi, Y.-D.; Song, L.; Gong, B.; Lu, Z.-L.* Gemini-type tetraphenylethylene amphiphiles containing [12]aneN3 and long hydrocarbon chains as nonviral gene vectors and gene delivery monitors. ACS Appl. Mater. Interfaces, 2017, 9, 11546-56. Li Z.-H.; Tan, Z.-L.; Ding. A-X.; Gong, B.; Lu, Z.-L.*; He L.,* Nitric oxide-responsive vesicles as a drug delivery system. Chem. Commun., 2017, 53, 3535-38. Wang, Q.-H.; Yu, L.-J.; Liu, Y.; Lin, L.; Lu, R.-G.; Zhu, J.-P.; He, L.*; Lu, Z.-L.*， Methods for the detection and determination of nitrite and nitrate: A review. Talanta, 2017, 165, 709-20. Ma S.-F., Wang Q.-H., Liu F.-T., Wang H.-L., Fang D.-C., Gong B., He L.*, Lu Z.-L.*, Dihydropyridine-based fluorescence probe for nitric oxide. RSC Adv., 2016, 6, 85698-703. Ding, A.-X.; Hao, H.-J.; Gao, Y.-G.; Shi, Y.-D.; Tang, Q.; Lu, Z.-L.*, D-A-D type chromophores with aggregation-induced emission and two-photon absorption: synthesis, optical characteristics and cell imaging. J. Mater. Chem. C 2016, 4 (23), 5379-5389.