Raines, Ronald T. - University of Wisconsin-Madison

个人简介

Sc.B. 1980, Massachusetts Institute of Technology A.M. 1982, Harvard University Ph.D. 1986, Harvard University

研究领域

The amino-acid sequences of proteins encode their three-dimensional structures, and these structures engender life. Using techniques that range from synthetic chemistry to cell biology, we are illuminating in atomic detail both the chemical basis and the biological purpose for protein structure and protein function. Our efforts are leading to insights into the relationship between amino-acid sequence and protein function (or dysfunction), as well as to the creation of novel proteins with desirable properties.

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Vasta JD, Andersen KA, Deck KM, Nizzi CP, Eisenstein RS, Raines RT. Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells. ACS Chemical Biology. 2016;11:193-199. Aronoff MR, Gold B, Raines RT. 1,3-Dipolar Cycloadditions of Diazo Compounds in the Presence of Azides. Organic Letters. 2016;18:1538-1541. Aronoff MR, Gold B, Raines RT. Rapid cycloaddition of a diazo group with an unstrained dipolarophile. Tetrahedron Letters. 2016;57:2347-2350. Arnold U, Raines RT. Replacing a single atom accelerates the folding of a protein and increases its thermostability. Organic & Biomolecular Chemistry. 2016;14:6780-6785. Gold B, Aronoff MR, Raines RT. Decreasing Distortion Energies without Strain: Diazo-Selective 1,3-Dipolar Cycloadditions. Journal of Organic Chemistry. 2016;81:5998-6006. Newberry RW, Orke SJ, Raines RT. n ->pi* Interactions Are Competitive with Hydrogen Bonds. Organic Letters. 2016;18:3614-3617. Gold B, Aronoff MR, Raines RT. 1,3-Dipolar Cycloaddition with Diazo Groups: Noncovalent Interactions Overwhelm Strain. Organic Letters. 2016;18:4466-4469. McGrath NA, Andersen KA, Davis AKF, Lomax JE, Raines RT. Diazo compounds for the bioreversible esterification of proteins. Chemical Science. 2015;6:752-755. Johnston SB, Raines RT. Catalysis by the Tumor-Suppressor Enzymes PTEN and PTEN-L. Plos One. 2015;10. Andersen KA, Martin LJ, Prince JM, Raines RT. Intrinsic site-selectivity of ubiquitin dimer formation. Protein Science. 2015;24:182-189. Marshall CJ, Grosskopf VA, Moehling TJ, Tillotson BJ, Wiepz GJ, Abbott NL, et al.. An Evolved Mxe GyrA Intein for Enhanced Production of Fusion Proteins. ACS Chemical Biology. 2015;10:527-538. Andersen KA, Aronoff MR, McGrath NA, Raines RT. Diazo Groups Endure Metabolism and Enable Chemoselectivity in Cellulo. Journal of the American Chemical Society. 2015;137:2412-2415. Johnston SB, Raines RT. Conformational Stability and Catalytic Activity of PTEN Variants Linked to Cancers and Autism Spectrum Disorders. Biochemistry. 2015;54:1576-1582. Tonelli M, Eller CH, Singarapu KK, Lee W, Bahrami A, Westler WM, et al.. Assignments of RNase A by ADAPT-NMR and enhancer. Biomolecular NMR Assignments. 2015;9:81-88. Underkofler KA, Teixeira RE, Pietsch SA, Knapp KG, Raines RT. Separation of Lignin from Corn Stover Hydrolysate with Quantitative Recovery of Ionic Liquid. Acs Sustainable Chemistry & Engineering. 2015;3:606-613. Newberry RW, VanVeller B, Raines RT. Thioamides in the collagen triple helix. Chemical Communications. 2015;51:9624-9627. Vasta JD, Raines RT. Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates. Bioorganic & Medicinal Chemistry. 2015;23:3081-3090. Mix KA, Raines RT. Optimized Diazo Scaffold for Protein Esterification. Organic Letters. 2015;17:2358-2361. Windsor IW, Raines RT. Fluorogenic Assay for Inhibitors of HIV-1 Protease with Sub-picomolar Affinity. Scientific Reports. 2015;5. Choudhary A, Kamer KJ, Shoulders MD, Raines RT. 4-Ketoproline: An Electrophilic Proline Analog for Bioconjugation. Biopolymers. 2015;104:110-115. Checco JW, Lee EF, Evangelista M, Sleebs NJ, Rogers K, Pettikiriarachchi A, et al.. alpha/beta-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells. Journal of the American Chemical Society. 2015;137:11365-11375. Caes BR, Teixeira RE, Knapp KG, Raines RT. Biomass to Furanics: Renewable Routes to Chemicals and Fuels. Acs Sustainable Chemistry & Engineering. 2015;3:2591-2605. Desai KK, Beltrame AL, Raines RT. Coevolution of RtcB and Archease created a multiple-turnover RNA ligase. RNA. 2015;21:1866-1872. Porter DF, Koh YY, VanVeller B, Raines RT, Wickens M. Target selection by natural and redesigned PUF proteins. Proceedings of the National Academy of Sciences of the United States of America. 2015;112:15868-15873. Ellison AJ, Van Veller B, Raines RT. Convenient synthesis of collagen-related tripeptides for segment condensation. Biopolymers. 2015;104:674-681. Zasadil LM, Andersen KA, Yeum D, Rocque GB, Wilke LG, Tevaarwerk AJ, et al.. Cytotoxicity of Paclitaxel in Breast Cancer Is due to Chromosome Missegregation on Multipolar Spindles. Science Translational Medicine. 2014;6. Newberry RW, Raines RT. A Key n ->pi* Interaction in N-Acyl Homoserine Lactones. ACS Chemical Biology. 2014;9:880-883. Newberry RW, Bartlett GJ, VanVeller B, Woolfson DN, Raines RT. Signatures of n ->pi* interactions in proteins. Protein Science. 2014;23:284-288. Lavis LD, Raines RT. Bright Building Blocks for Chemical Biology. ACS Chemical Biology. 2014;9:855-866. D'Avino C, Paciello R, Riccio G, Coppola M, Laccetti P, Maurea N, et al.. Effects of a second-generation human anti-ErbB2 ImmunoRNase on trastuzumab-resistant tumors and cardiac cells. Protein Engineering Design & Selection. 2014;27:83-88. Chattopadhyay S, Raines RT. Collagen-Based Biomaterials for Wound Healing. Biopolymers. 2014;101:821-833. Lomax JE, Bianchettl CM, Chang A, Phillips GN, Fox BG, Raines RT. Functional Evolution of Ribonuclease Inhibitor: Insights from Birds and Reptiles. Journal of Molecular Biology. 2014;426:3041-3056. Choudhary A, Newberry RW, Raines RT. n ->pi* Interactions Engender Chirality in Carbonyl Groups. Organic Letters. 2014;16:3421-3423. Lukesh JC, Wallin KK, Raines RT. Pyrazine-derived disulfide-reducing agent for chemical biology. Chemical Communications. 2014;50:9591-9594. Eller CH, Lomax JE, Raines RT. Bovine Brain Ribonuclease Is the Functional Homolog of Human Ribonuclease 1. Journal of Biological Chemistry. 2014;289:25996-26006. Eller CH, Yang GB, Ouerfelli O, Raines RT. Affinity of monoclonal antibodies for Globo-series glycans. Carbohydrate Research. 2014;397:1-6. Bingman CA, Cheng CL, Phillips GN, Raines RT. Structure of RNA 3 '-phosphate cyclase bound to substrate RNA AU Desai, KK Bingman, CA Cheng, CL Phillips, GN Raines, RT. RNA-a Publication of the RNA Society. 2014;20:1560-1566. Tanrikulu IC, Raines RT. Optimal Interstrand Bridges for Collagen-like Biomaterials. Journal of the American Chemical Society. 2014;136:13490-13493. Lukesh JC, Andersen KA, Wallin KK, Raines RT. Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase. Organic & Biomolecular Chemistry. 2014;12:8598-8602. Desai KK, Cheng CL, Bingman CA, Phillips GN, Raines RT. A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation. Nucleic Acids Research. 2014;42:3931-3942.