个人简介

Dr. Torres received his B.S. in Molecular, Cellular, and Developmental Biology from the University of California at Santa Barbara in 1998, where he conducted research under the mentorship of Dr. Eduardo Orias. He obtained his Ph.D. in Molecular Biology from Princeton University in 2004 under the direction of Dr. Virginia A. Zakian. He conducted his postdoctoral work in the laboratory of Dr. Peter K. Jackson at the Stanford University School of Medicine and Genentech Inc. until 2009 when he joined the faculty in the Department of Chemistry and Biochemistry at UCLA.

研究领域

Biochemistry/Systems Biology and Biological Regulation

The lab's major focus is to understand how multiple mechanisms and enzymatic activities coordinate the formation of the mitotic microtubule spindle during cell division. We are interested in identifying and characterizing novel proteins that are required for proper mitotic spindle assembly. Among these are molecular motors, phosphatases, methyltranferases, and ubiquitin ligases. We use human cell lines and in vitro systems along with a combination of approaches, including biochemistry, molecular biology, cell biology, chemical biology, and microscopy to determine the mechanism of action of these proteins.

近期论文

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Theoretical Approaches to Identify the Potent Scaffold for Human Sirtuin 1 Activator: Bayesian Modeling and Density Functional Theory Sakkiah,S., Arooj M., Lee K., and Torres J.Z. Medicinal Chemistry Research 2014 March 09, 23(5) 2161-2700. PMCID: In Progress Dynamic and Multi-pharmacophore Modeling for Designing Polo-box Domain Inhibitors Sakkiah S., Senese S., Yang Q., Lee K., and Torres J.Z. Plos One 2014 Jul 18, 9(7):e101405. PMCID: PMC4103762 An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ. Cancer Research 2013 Apr 22;73:2850-2862 STARD9 is a novel mitotic kinesin and antimitotic target Torres, J.Z. BioArchitecture 2012 Jan 1;2(1):19-22. The STARD9/Kif16a Kinesin Associates with Mitotic Microtubules and Regulates Spindle Pole Assembly Torres J.Z., Summers M.K., Peterson D., Brauer M.J., Lee J., Senese S., Gholkar A.A., Lo Y., Lei X., Jung K., Anderson D.C., Davis D.P., Belmont L., and Jackson P.K. Cell 2011, Dec;9(6):1309-1323. A specific form of PPP2 regulates APC/C association with spindle poles Torres J.Z., Ban K.H., and Jackson P.K. Molecular Biology of the Cell. 2010 Mar;21(6):897-904.;21 897-904 High-throughput generation of tagged stable cell lines for proteomic analysis. Torres Jorge Z, Miller Julie J, Jackson Peter K Proteomics, 2009; 9(10): 2888-91. The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Ban Kenneth H, Torres Jorge Z, Miller Julie J, Mikhailov Alexei, Nachury Maxence V, Tung Jeffrey J, Rieder Conly L, Jackson Peter K Developmental cell, 2007; 13(1): 29-42.