李鲜婵 - 北京大学

个人简介

2000-2004 北京大学药学院学士 2004-2009 中国科学院化学研究所博士 2009-2013 中国科学院化学研究所助理研究员 2013-2015 瑞典查尔姆斯理工大学博士后 2015-2018 瑞典哥德堡大学研究员 2019-2021 中央民族大学教授、课题组长、博士生导师 2021- 北京大学药学院研究员、课题组长、博士生导师

研究领域

微纳电化学传感策略和药物分析应用神经化学信号转导的分析与生理药理调控生物分析策略与药物开发神经系统疾病分子机制、药物新靶点发现及药物干预机制研究

近期论文

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Qingwei Yue, Kai Wang, Ming Guan, Zhenwen Zhao, Xianchan Li*, Ping Yu, Lanqun Mao*, Single-Vesicle Electrochemistry Reveals Sex Difference in Vesicular Storage and Release of Catecholamine. Angew. Chem. Int. Ed. 2022, 61, e202117. DOI: 10.1002/anie.202117596. Mengying Wang, Yuying Liu, Jinchang Du, Junlan Zhou, Lijiao Cao, Xianchan Li*，Cisplatin Inhibits Neurotransmitter Release during Exocytosis from Single Chromaffin Cells Monitored with Single Cell Amperometry. Electroanalysis, 2021. DOI: 10.1002/elan.202100398 (Invited) Yuying Liu,? Jinchang Du,? Mengying Wang, Jing Zhang, Chunlan Liu* and Xianchan Li*, Recent Progress in Quantitatively Monitoring Vesicular Neurotransmitter Release and Storage with Micro/Nanoelectrodes. Front. Chem. 2021, 8, 591311. (Invited) Qingwei Yue,? Xianchan Li,? Fei Wu, Wenliang Ji, Yue Zhang, Ping Yu, Meining Zhang, Wenjie Ma, Ming Wang, Lanqun Mao*. Unveiling the Role of DJ‐1 Protein in Vesicular Storage and Release of Catecholamine with Nano/Micro‐Tip Electrodes, Angew. Chem. Int. Ed. 2020, 59, 11061– 11065. (Co-first authors) Dalei Wang,? Xianchan Li,? Ying Jiang, Yanan Jiang, Wenjie Ma, Ping Yu, and Lanqun Mao*. Ischemic Postconditioning Recovers Cortex Ascorbic Acid during Ischemia/Reperfusion Monitored with an Online Electrochemical System. ACS Chem. Neurosci. 2019, 10, 2576-2583. (Co-first authors) Tongfang Xiao,? Xianchan Li,? Huan Wei, Wenliang Ji, Qingwei Yue, Ping Yu, Lanqun Mao*In Vivo Monitoring of Oxygen Fluctuation Simultaneously at Multiple Sites of Rat Cortex during Spreading Depression. Anal. Chem. 2018, 90, 13783-13789. (Co-first authors) Amir S Mohammadi,? Xianchan Li?, Andrew G. Ewing*. Mass Spectrometry Imaging Suggests That Cisplatin Affects Exocytotic Release by Alteration of Cell Membrane Lipids. Anal. Chem. 2018, 90, 8509-8516. (Co-first authors) Xianchan Li, Lin Ren, Johan Dunevall, Daixin Ye, Henry S. White, Martin A. Edwards*, Andrew G. Ewing*. On the Nanopore Opening at Flat and Nano-Tip Conical Electrodes during Vesicle Impact Electrochemical Cytometry. ACS Nano, 2018,12, 3010-3019. Xianchan Li, Johan Dunevall, Lin Ren, Andrew G. Ewing*. Mechanistic Aspects of Vesicle Opening during Analysis with Vesicle Impact Electrochemical Cytometry. Anal. Chem. 2017, 89, 9416?9423. Nhu T.N. Phan, Xianchan Li, Andrew G. Ewing*. Measurement of synaptic vesicles: from the chemical content to structure and activity using cellular electrochemistry and nanoscale molecular imaging. Nature Reviews Chemistry, 2017, 1, 0048. Xianchan Li,? Johan Dunevall,? Andrew G. Ewing*. Quantitative Chemical Measurements of Vesicular Transmitters with Electrochemical Cytometry. Acc. Chem. Res. 2016, 49, 2347-2354. Xianchan Li, Johan Dunevall, Andrew G. Ewing*. Using Single-Cell Amperometry to Reveal How Cisplatin Treatment Modulates the Release of Catecholamine Transmitters during Exocytosis. Angew. Chem. Int. Ed. 2016, 55, 9041-9044. Cover：Angew. Chem. Int. Ed. 2016, 55, 9098. Xianchan Li,? Soodabeh Majdi,? Johan Dunevall, Hoda Fathali, Andrew G. Ewing*. Quantitative Measurement of Transmitters in Individual Vesicles in the Cytoplasm of Single Cells with Nanotip Electrodes. Angew. Chem. Int. Ed. 2015, 54, 11978-11982. Xianchan Li, Ping Yu, Lifen Yang, Fuyi Wang, Lanqun Mao*. An Electrochemical Method for Investigation of Conformational Flexibility of Active Sites of Trametes versicolor Laccase Based on Sensitive Determination of Copper Ion with Cysteine-Modified Electrodes. Anal.Chem. 2012, 84, 9416-9421. Xianchan Li, Lingzhi Zhao, Zhenling Chen, Yuqing Lin, Ping Yu, Lanqun Mao*. Continuous Electrochemical Monitoring of Extracellular Lactate Production from Neonatal Rat Cardiomyocytes following Myocardial Hypoxia. Anal.Chem. 2012, 84, 5285-5291. Xianchan Li, Wei Zheng, Limin Zhang, Ping Yu, Yuqing Lin, Lei Su, Lanqun Mao*. Effective Electrochemical Method for Investigation of Hemoglobin Unfolding Based on the Redox Property of Heme Groups at Glassy Carbon Electrodes. Anal. Chem. 2009, 81, 8557-8563.