罗佗平 - 北京大学 - 化学与分子工程学院

个人简介

2013起，预备研究员，博士生导师，北京大学－清华大学生命科学联合中心 2013起，研究员，博士生导师，北京大学化学与分子工程学院 2011-2013 ，博士后，美国H3生物制药公司 2005-2011 ，理学博士，美国哈佛大学化学与化学生物学系 2001-2005 ，理学学士，北京大学化学与分子工程学院

研究领域

本研究小组将致力于发展和应用有机化学的新反应、新方法，并以此为工具来推动生命科学,尤其是化学生物学和与创新药物相关的研究。围绕这个中心，我们一方面将通过广泛的合作来研究和开发新的小分子探针和基于化学的各种生物技术；另一方面，我们将对现有的化学反应或方法提出新的挑战，并研究新的方法或原理来发展更有效率的化学。具体的工作将主要集中在两个方向。第一个方向即在化学基因组学的大背景下，围绕某一特定的化合物，尤其是高生物活性的复杂天然产物小分子，研究实现高效的化学合成、结构修饰和性质优化。其中的研究课题包括但不限于1)一系列调节烟碱型乙酰胆碱受体的生物碱,2)作为植物荷尔蒙的萜类分子。第二个方向的研究内容将围绕某一特定的蛋白大分子，尤其是药物靶点蛋白，发展新的研究工具和手段，探索能够为生命科学问题的研究提供新视角的化学。例如，1）运用“bump-hole”策略通过操控蛋白／小分子探针的结合位点来建立研究特定的酶作用和功能的实验体系，2）开发新型的生物正交反应，3）制备原位激活的探针分子用于研究特定的激酶或G蛋白偶联受体

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Enantioselective Total Syntheses of Grayanane Diterpenoids and (+)-Kalmanol: Evolution of the Bridgehead Carbocation-Based Cyclization and Late-Stage Functional Group Manipulation Strategies Kong, L.; Yu, H.; Deng, M.; Wu, F.; Chen, S.-C.; Luo, T. J. Org. Chem. 2023, 88, 6017−6038. Pro-aromaticity Enabled Dealkenylative Functionalizations via Photo-excitation and Oxidation Chen, S.-C.; Zhu, Q.; Chen, H.; Chen, Z. Luo, T. Chem. Eur. J. 2023, 29, e202203425. Total Synthesis of (+)-Mutilin: A Transannular [2+2] Cycloaddition/Fragmentation Approach Chen, H.; Li, Z.; Shao, P.; Yuan, H.; Chen, S.-C.; Luo, T. J. Am. Chem. Soc. 2022, 144, 15462−15467. Tonsillar Microbiome-Derived Lantibiotics Induce Structural Changes of IL-6 and IL-21 Receptors and Modulate Host Immunity Li, J.; Jin, J.; Li, S.; Zhong, Y.; Jin, Y.; Zhang, X.; Xia, B.; Zhu, Y.; Guo, R.; Sun, X.; Guo, J.; Hu, F.; Xiao, W.; Huang, F.; Ye, H.; Li, R.; Zhou, Y.; Xiang, X.; Yao, H.; Yan, Q.; Su, L.; Wu, L.; Luo, T.; Liu, Y.; Guo, X.; Qin, J.; He, J.; Wang, J.; Li, Z. Adv. Sci. 2022, 9, 202202706. Overcoming Antibiotic Resistance by Efficient and Scalable Total Synthesis Jiao, Y.; Luo, T. Nat. Sci. Rev. 2022, 9, nwac029. Enantioselective Total Syntheses of Grayanane Diterpenoids: (–)-Grayanotoxin III, (+)-Principinol E, and (–)-Rhodomollein XX Kong, L.; Yu, H.; Deng, M.; Wu, F.; Jiang, Z.; Luo, T. J. Am. Chem. Soc. 2022, 144, 5268−5273. Scalable Total Synthesis of (−)-Triptonide: Serendipitous Discovery of a Visible-Light-Promoted Olefin Coupling Initiated by Metal-Catalyzed Hydrogen Atom Transfer (MHAT) Fang, X.; Zhang, N.; Chen, S.-C.; Luo, T. J. Am. Chem. Soc. 2022, 144, 2292−2300. Effective Treatment of SARS-CoV-2-infected Rhesus Macaques by Attenuating Inflammation Lu, S.; Zhao, J.; Dong J.; Liu, H.; Zhu, Y.; Li, H.; Liu, L.; Yang, Y.; Sun, S.; Song, Y.; Zhao, Y.; She, R.; Luo, T.; Deng H.; Peng, X. Cell Research 2021, 31, 229-232. Dealkenylative Ni-Catalyzed Cross-Coupling Enabled by Tetrazine and Photoexcitation Chen, S.-C.; Zhu, Q.; Cao, Y.; Li, C.; Guo, Y.; Kong, L.; Che, J.; Guo, Z.; Chen, H.; Zhang, N.; Fang X.; Lu, J.; Luo, T. J. Am. Chem. Soc. 2021, 143, 14046-14052. Elimination of Senescent Cells by β-Galactosidase-Targeted Prodrug Attenuates Inflammation and Restores Physical Function in Aged Mice Cai, Y.; Zhou, H.; Zhu, Y.; Sun, Q.; Ji, Y.; Xue, A.; Wang, Y.; Chen, W.; Yu, X.; Wang, Y.; Wang, L.; Chen, H.; Li, C.; Luo, T.; Deng, H. Cell Res. 2020, 30, 574-589. Structural Insights Into the Inhibition Mechanism of Human Sterol O-acyltransferase 1 by a Competitive Inhibitor Guan, C.; Niu, Y.; Chen, S.-C.; Kang, Y.; Wu, J.-X.; Nishi, K.; Chang, C. C. Y.; Chang, T.-Y.; Luo, T.; Chen, L. Nat. Commun. 2020, 11, 2478. Late-Stage Diversification of Natural Products Hong, B.; Luo, T.; Lei, X. ACS Cent. Sci. 2020, 6, 622-653. Total Synthesis of (–)-Batrachotoxinin A: A Local-Desymmetrization Approach Guo, Y.; Guo, Z.; Lu, J.-T.; Fang, R.; Chen, S.-C.; Luo, T. J. Am. Chem. Soc. 2020, 142, 3675−3679. Synthesis of 17-Deacetoxyl Chromodorolide B Based on a Gold-Catalyzed Alkoxycyclization Reaction Li, C.; Quan, T.; Xue, Y.; Cao, Y.; Chen, S.-C.; Luo, T. Org. Lett. 2020, 22, 1655−1658. Total Synthesis of (−)-Oridonin: An Interrupted-Nazarov Approach Kong, L.; Su, F.; Yu, H.; Jiang, Z.; Lu, Y.; Luo, T. J. Am. Chem. Soc. 2019, 141, 20048−20052. A Modular PROTAC Design for Target Destruction Using A Degradation Signal Based on A Single Amino Acid Shanmugasundaram, K.; Shao, P.; Chen, H.; Campos, B.; McHardy, S. F.; Luo, T.; Rao, H. J. Biol. Chem. 2019, 294, 15172-15175. Scalable Total Synthesis of (−)-Vinigrol Yu, X.; Xiao, L.; Wang, Z.; Luo, T. J. Am. Chem. Soc. 2019, 141, 3440-3443. Enantioselective syntheses and application of 4-epi-galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles Lu, Y.; Zhao, S.; Zhou. S.; Chen, S.-C.; Luo, T. Org. Biomol. Chem. 2019, 17, 1886-1892. Chemoproteomics Reveals Baicalin Activates Hepatic CPT1 to Ameliorate Diet-induced Obesity and Hepatic Steatosis Dai, J.; Liang, K.; Zhao, S.; Jia, W.; Liu, Y.; Wu, H.; Lv, J.; Cao, C.; Chen, T.; Zhuang, S.; Hou, X.; Zhou, S.; Zhang, X.; Chen, X.-W.; Huang, Y.; Xiao, R.-P.; Wang, Y.-L.; Luo, T.; Xiao, J.; Wang, C. Proc. Natl. Acad. Soc., USA 2018, 115, E5895-E5905. Total Synthesis of Maoecrystal P: Application of a Strained Bicyclic Synthon Su, F.; Lu, Y.; Kong, L.; Liu, J.; Luo, T. Angew. Chem. Int. Ed. 2018, 57, 760-764. Simple β-Lactones are Potent Irreversible Antagonists for Strigolactone Receptors Xiang, H.; Yao, R.; Quan, T.; Wang, F.; Chen, L.; Du, X.; Zhang, W.; Deng, H.; Xie, D.; Luo, T. Cell Res. 2017, 27, 1525-1528. An Unexpected Aziridination/Rearrangement/Oxidation Tandem Reaction Leading to the Total Synthesis of (−)-Mersicarpine Zhang, Y.; Xue, Y.; Luo, T. Tetrahedron 2017, 73, 4201-4205. Enantioselective Total Synthesis of (+)-Wortmannin Guo, Y.; Quan, T.; Lu, Y.; Luo, T. J. Am. Chem. Soc. 2017, 139, 6815-6818. Synthesis of (+)-Lysergol and Its Analogues To Assess Serotonin Receptor Activity Yuan, H.; Guo, Z.; Luo, T. Org. Lett. 2017, 19, 624-627.