当前位置: X-MOL首页全球导师 国内导师 › 吴云东

个人简介

Education Ph.D., Theoretical Organic Chemistry, 1986, University of Pittsburgh; B.S., Physical Chemistry, 1981, Lanzhou University, P.R.C. Working Experience 2019.03- Present Executive Vice Director, Shenzhen Bay Laboratory 2016.03 - 2019.03 Chancellor, Peking University Shenzhen Graduate School 2010.09 - Present Chair Professor, College of Chemistry, Peking University Chair Professor, School of Chemical Biology & Biotechnology, PKUSZ 2007.07 - 2010.09 Chair Professor, Department of Chemistry, HKUST 2001.07 - 2010.09 Professor, Department of Chemistry, HKUST 1995.07 - 2001 Associate Professor, Department of Chemistry, HKUST (A-scale since 1998). 1992.06 - 1995.06 Lecturer/Assistant Professor, Department of Chemistry, HKUST 1988.06 - 1992.06 Research Associate of Prof. K. N. Houk at UCLA. Division at the National Science Foundation from June 1988 to May 1990. 1988.01 - 1988.05 Visiting scholar with Prof. P. v. R. Schleyer, University of Erlangen-Nürnberg, Erlangen, Germany 1986 - 1987 Postdoctoral with Prof. K. N. Houk at UCLA 1982 - 1986 Teaching Assistant and Research Assistant, University of Pittsburgh

研究领域

1) small molecule inhibitor screeing based on structure and function prediction of WD40-repeat proteins. 2) Designing small molecules for the treatment of Alzheimer’s disease, which is caused by accumulation of A-beta. 3) Development of new modeling methods and simulation tools with autonomous intellectual property. 4) Designing small molecules for cancer treatments. 5) Mechanism of asymmetric synthesis and catalytic reactions.

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

Enantioselective Intermolecular Heck and Reductive Heck Reactions of Aryl Triflates, Mesylates, and Tosylates Catalyzed by Nickel Angew. Chem. Int. Ed. 2021, 60, 2828 – 2832 Xiaolei Huang, Shenghan Teng, Yonggui Robin Chi, Wenqiang Xu, Maoping Pu, Yun-Dong Wu, and Jianrong Steve Zhou* Iron-catalysed asymmetric carboazidation of styrenes Nat Catal. 2020, 4, 28–35 Liang Ge, Huan Zhou, Mong-Feng Chiou, Heming Jiang, Wujun Jian, Changqing Ye, Xiaoyan Li, Xiaotao Zhu, Haigen Xiong, Yajun Li , Lijuan Song, Xinhao Zhang*,  and Hongli Bao* Copper-Catalyzed Enantioselective Radical 1, 4-Difunctionalization of 1, 3-Enynes J. Am. Chem. Soc. 2020, 142, 18014–18021 Yuehua Zeng, Mong-Feng Chiou, Xiaotao Zhu, Jie Cao, Daqi Lv, Wujun Jian, Yajun Li, Xinhao Zhang*, and Hongli Bao* Computational Study on the Fate of Oxidative Directing Groups in Ru(II), Rh(III), and Pd(II) Catalyzed C-H Functionalization J. Org. Chem. 2020, 85, 12594–12602 Siqi Liu, Maoping Pu, Yun-Dong Wu*, and Xinhao Zhang* IDRMutPred: predicting disease-associated germline nonsynonymous single nucleotide variants (nsSNVs) in intrinsically disordered regions Bioinformatics, 2020, 36, 4977–4983 Jing-Bo Zhou, Yao Xiong, Ke An, Zhi-Qiang Ye,* and Yun-Dong Wu* Ru-Catalyzed Geminal Hydroboration of Silyl Alkynes via a New gem-Addition Mechanism J. Am. Chem. Soc. 2020, 142, 13867–13877 Qiang Feng, Haonan Wu, Xin Li, Lijuan Song, Lung Wa Chung*, Yun-Dong Wu*, and Jianwei Sun* Diastereo- and Enantioselective Catalytic Radical Oxysulfonylation of Alkenes in β,γ-Unsaturated Ketoximes Chem. 2020, 6, 1692–1706 Xi-Tao Li, Ling Lv, Ting Wang, Qiang-Shuai Gu, Guo-Xing Xu, Zhong-Liang Li, Liu Ye, Xinhao Zhang, Gui-Juan Cheng,* and Xin-Yuan Liu* Hybrid Palladium Catalyst Assembled from Chiral Phosphoric Acid and Thioamide for Enantioselective β‐C(sp3)-H Arylation Angew. Chem. Int. Ed. 2020, 59, 12774–12778 Hua-Jie Jiang, Xiu-Mei Zhong, Zi-Ye Liu, Rui-Long Geng, Yang-Yang Li, Yun-Dong Wu, Xinhao Zhang,* and Liu-Zhu Gong* Synthesis of ortho-Phenolic Sulfilimines via an Intermolecular Sulfur Atom Transfer Cascade Reaction Org. Lett. 2020, 22, 3799–3803 Feng Xiong,* Yingying Zuo, Yinan Song, Linxing Zhang, Xinhao Zhang,* Shaojian Xu and Yan Ren* CRiSP: accurate structure prediction of disulfide-rich peptides with cystine-specific sequence alignment and machine learning Bioinformatics. 2020, 36, 3385–3392 Zi-Lin Liu, Jing-Hao Hu, Fan Jiang* and Yun-Dong Wu* Asymmetric Reductive and Alkynylative Heck Bicyclization of Enynes to Access Conformationally Restricted Aza[3.1.0]bicycles Angew. Chem. Int. Ed. 2020, 59, 10814-10818 Xiaolei Huang, Minh Hieu Nguyen, Maoping Pu, Luoqiang Zhang, Yonggui Robin Chi, Yun-Dong Wu, and Jianrong Steve Zhou* Organocatalytic nitrogen transfer to unactivated olefins via transient oxaziridines Nat Catal. 2020, 3, 386–392 Qing-Qing Cheng  , Zhe Zhou  , Heming Jiang, Juha H. Siitonen, Daniel H. Ess, Xinhao Zhang  and László Kürti * Ligand-Controlled C-O Bond Coupling of Carboxylic Acids and Aryl Iodides: Experimental and Computational Insights Adv. Synth. Catal. 2020, 362, 126 – 132 Li Li, Feifei Song, Xiumei Zhong, Yun-Dong Wu, Xinhao Zhang,*Jiean Chen,* and Yong Huang* Computational Methods for Studying Conformational Behaviors of Cyclic Peptides[M] Fan Jiang, Hao Geng Applications of Molecular Dynamics Simulation in Structure Prediction of Peptides and Proteins Comput Struct Biotechnol J. 2019, 17, 1162-1170 HaoGeng, FangfangChen, JingYe, FanJiang* Copper-Catalyzed Radical 1,4-Difunctionalization of 1,3-Enynes with Alkyl Diacyl Peroxides and N-Fluorobenzenesulfonimide J. Am. Chem. Soc. 2019, 141, 1, 548–559 Xiaotao Zhu, Weili Deng, Mong-Feng Chiou, Changqing Ye, Wujun Jian, Yuehua Zeng, Yihang Jiao, Liang Ge, Yajun Li, Xinhao Zhang*, and Hongli Bao* Iron-catalyzed carboazidation of alkenes and alkynes Nat Commun. 2019, 10,122 Haigen Xiong, Nagarajan Ramkumar, Mong-Feng Chiou, Wujun Jian, Yajun Li, Ji-Hu SuXinhao Zhang & Hongli Bao* The reaction of alkyl hydropersulfides (RSSH, R = CH3 and Bu-t) with H2S in the gas phase and in aqueous solution Phys. Chem. Chem. Phys. 2019,21, 537-545 Linxing Zhang, Xinhao Zhang, Yun-Dong Wu,*Yaoming Xie, Jon M. Fukuto and Henry F. Schaefer III* A Missing Piece of the Mechanism in Metal-Catalyzed Hydrogenation: Co(-I)/Co(0)/Co(+I) Catalytic Cycle for Co(-I)-Catalyzed Hydrogenation Org. Lett. 2019, 21, 2, 360–364 Song-Bai Wu, Tonghuan Zhang, Lung Wa Chung*, and Yun-Dong Wu Enantioselective Addition of Cyclic Ketones to Unactivated Alkenes Enabled by Amine/Pd(II) Cooperative Catalysis ACS Catal. 2019, 9, 2, 791–797 Hong-Cheng Shen, Ling Zhang, Shu-Sen Chen, Jiajie Feng, Bo-Wen Zhang, Ying Zhang, Xinhao Zhang*, Yun-Dong Wu, and Liu-Zhu Gong*

推荐链接
down
wechat
bug