个人简介

Dr. Quinlan obtained her B.A. at Reed College in 1991. She then spent two years in Germany doing research at the University of Erlangen-Nurnberg. She went to graduate school at the University of Pennsylvania where she worked with Yale Goldman and received her Ph.D. in 2002. She worked as a postdoctoral fellow at UCSF with Dyche Mullins until 2008 when she joined the faculty in the Department of Chemistry and Biochemistry at UCLA.

研究领域

Biochemistry/Structural and Computational Biology/Systems Biology and Biological Regulation/Metabolism/Aging and Development/Biophysics

We are using biochemistry, microscopy and genetic approaches to study dynamics of the actin cytoskeleton. We are currently focusing on Spire and Cappuccino, two proteins that collaborate to build an actin network essential for early body axis development in Drosophila. Combining an in vitro understanding of the mechanism of Spir and Capu with in vivo studies of oogenesis will provide insight into how the actin cytoskeleton is regulated and a broader understanding of cell polarity. In the Quinlan lab we are addressing four questions: Molecular Mechanism: How do Spir and Capu collaborate? Cell Biology: What role does the Spir-Capu complex play in Drosophila oogenesis? Regulation: How is the Spir-Capu complex regulated? Mammalian Disease: Is the Spir-Capu complex a polarity factor in other cell types?

近期论文

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Roth-Johnson, E.A., Vizcarra, C.L., Bois, J.S., and M.E. Quinlan. Interaction between microtubules and the Drosophila formin Cappuccino and its effect on actin assembly. J Biol Chem. Feb 14;289(7):4395-404, 2014. PMCID: PMC3924302. [pdf] - Elizabeth Roth-Johnson is a graduate student and Drs. Vizcarra and Bois are postdocs in the lab. Quinlan, M.E. Direct interaction between two actin nucleators is required in Drosophila oogenesis. Development Nov;140(21):4417-25, 2013. PMCID:PMC4007717. [pdf] Bor, B., Vizcarra, C.L., Phillips, M.L., and M.E. Quinlan. Autoinhibition of the formin Cappuccino in the absence of canonical autoinhibitory domains. Mol. Biol. of the Cell 23:3801-3813, 2012. PMCID: PMC3459857. [pdf] - Batbileg Bor is a graduate student and Christina Vizcarra is a postdoc in the lab. Chen, C.K., Sawaya, M.R., Phillips, M.L., Reisler, E., and M.E. Quinlan. Multiple forms of Spire-actin complexes and their functional consequences. J. Biol. Chem. 287:10684-10692, 2012. PMCID: PMC3323035. [pdf] - Christine Chen is a former graduate student in the Reisler lab Vizcarra, C.L.1, Kreutz, B.1, Rodal, A.A., Toms, A.V., Lu, J., Zhang, W., Quinlan, M.E.*, and M.J. Eck*. Structure and function of the interacting domains of Spire and Fmn-family formins. PNAS. 108:11884-11889, 2011. PMCID: PMC3141961. 1authors contributed equally, *co-corresponding authors [pdf] - Christina Vizcarra is a postdoc in the lab. Zuchero, J.B., Coutts, A.S., Quinlan, M.E., Thangue, N.B., and R.D. Mullins. p53-cofactor JMY is a multifunctional actin nucleation factor. Nat Cell Biol. 11:451-459, 2009. PMCID: PMC2763628. [pdf] Quinlan, M.E. and E. Kerkhoff. Actin nucleation: bacteria get in-Spired. Nat Cell Biol. Jan; 10(1):13-5, 2008. [pdf] Quinlan, M.E., Hilgert, S., Bedrossian, A., Mullins, R.D., and E. Kerkhoff. Regulatory interactions between two actin nucleators, Spire and Cappuccino. J Cell Biol. Oct 8;179(1):117-28, 2007. PMCID:PMC2064741. [pdf] [cover] Quinlan M.E., Heuser, J.E., Kerkhoff, E., and R.D. Mullins. Drosophila Spire is an actin nucleation factor. Nature Jan 27;433(7024):382-8, 2005. [pdf]