个人简介
1992-至今 教授,北京大学化学与分子工程学院
1990-1992 副教授,北京大学化学系
1984-1990 助教,北京大学化学系
1989-1990 博士后,麻省理工学院化学系
1988 博士,加州大学伯克利分校化学系
1984 硕士,北京大学化学系
1982 学士,北京大学化学系
研究领域
赵新生教授系统而独到地揭示了核酸杂交和修饰的微观动力学机理,从单分子水平阐释了单链DNA链内碰撞、发卡DNA折叠、双链DNA中单个错配的自然翻转、DNA杂交、核酸修饰的微观动力学规律;刻划了新一类拓扑结构的蛋白质—打结蛋白—的塌缩动力学行为;发现动力学因素在细菌对外膜蛋白进行保护和质量控制中起关键作用;发展了荧光相关谱方法
近期论文
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Geng Li, Chenhui He, Peixuan Bu, Huimin Bi, Sichen Pan, Ronghua Sun, Xin Sheng Zhao*, ACS Chem. Biol. 2018, 13, 1082−1089. Single-Molecule Detection Reveals Different Roles of Skp and SurA as Chaperones.
Lingyi Meng, Shanshan He, Xin Sheng Zhao*, J. Phys. Chem. B 2017, 121, 11262–11272. Determination of Equilibrium Constant and Relative Brightness in FRET-FCS by Including the Third-Order Correlations.
Huimin Bi, Yandong Yin, Bailong Pan, Geng Li, Xin Sheng Zhao*, J. Phys. Chem. Lett. 2016, 7, 1865-1871. Scanning Single-Molecule Fluorescence Correlation Spectroscopy Enables Kinetics Study of DNA Hairpin Folding with a Time Window from Microseconds to Seconds.
Peng Wang, Lijiang Yang, Yi Qin Gao*, Xin Sheng Zhao*, Nucleic Acids Res. 2015, 43, 7207-7216. Accurate Placement of Substrate RNA by Gar1 in H/ACA RNA-guided Pseudouridylation.
Yandong Yin, Lijiang Yang, Guanqun Zheng, Chan Gu, Chengqi Yi, Chuan He, Yi Qin Gao*, and Xin Sheng Zhao*, PNAS 2014, 111, 8043-8048. Dynamics of spontaneous flipping of a mismatched base in DNA duplex.