个人简介
EDUCATION
1989 – 1992 Ph.D., Chemistry, The Chinese University of Hong Kong, with Professor Henry N. C. Wong
1983 – 1986 M.S., Pharmaceutical Chemistry, Shenyang College of Pharmacy, with Professor Qihuai Chen
1978 – 1982 B.A., Pharmaceutical Chemistry, Shenyang College of Pharmacy
PROFESSIONAL EXPERIENCE
2011-Curr.Professor of Chemistry, Peking University-Tsinghua University Joint Center for Life Sciences (PTCLS)
2008-Curr.Professor of Chemistry, School of Chemical Biology and Biotechnology, Peking University
2002 – Curr.Professor of Chemistry, Dept. of Chemistry, Peking University
2005 – 2008 Director of Chemistry, XTL biopharmaceutical Inc. NY
2001 – 2005 Co-founders and Director of Chemistry, VivoQuest Inc. NY
1998 – 2001 Institute Fellow, Dept. of Cell biology, Harvard Medical School
1995 – 1998 Assistant professor, Dept. of Chemistry, The Scripps Research Institute
1992 – 1995 Postdoctoral Fellow, Dept. of Chemistry, The Scripps Research Institute, with Professor K. C. Nicolaou
HONORS AND AWARDS
2000 The National Science Fund for Distinguished Young Investigator Award (abroad), NSF of China
2004 The National Science Fund for Distinguished Young Investigator Award, NSF of China
2005 Eli Lilly Scientific Excellence Award (China)
2008 The Asian Core Program Lectureship Award, the Asian Cutting-Edge Organic Chemistry programs
2009 Baogang Distinguished Teaching Award of Peking University
2010 Wuxi Pharma Life Science Excellence Award (Golden Metal)
2013“Zhou Weishan” Synthetic Creative Work Award, Chemical Society of China
2016 Second Prize of National Natural Science Award, China
2018 Shenzhen mayor Award, Shenzhen
2023 Foreign Member of the Russian Academy of Engineering, RAE
近期论文
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Formation of Multiple Naturally Occurring Meroterpenoid Scaffolds by the Norrish-Yang Reaction of a p-Benzoquinone Bing-Yan Liu+, Zi-Chun Zhang+, Zhi-Lin Song, Hong-Yi Yuan, Yuan-He Li, Zhong-Chao Zhang,* Zhen Yang* Angew. Chem. Int. Ed. 2024, 63, e202415249
Synthesis of Poly-substituted 2-Hydroxycyclobutanones via Norrish–Yang Photocyclization/1,2-Methyl Migration: Scope and limitations Fu Tang, Zhongchao Zhang*, Zhen Yang* Tetrahedron Lett. 2024, 145, 155161.
A Norrish-Yang photocyclization reaction has been applied to regio- and stereoselective construction of the ABCDE pentacyclic motif of natural product phainanoids. The observed substrate conformation control implicates this powerful reaction could be applied to the construction of structurally diverse natural product scaffolds. Yi-Ke Zhou, Zhen-Yu Zhang, Hao-Yuan Liu, Yuan-He Li, Zhong-Chao Zhang, Jia-Hua Chen*, Zhen Yang* Org. Lett. 2024, 26, 8217–8221.
Exo-Selective Diels–Alder Reactions Yuan-He Li,* Jia-Hua Chen, and Zhen Yang* Chem. Eur. J. 2024. 30(17), e202304371
Exo-Selective Diels–Alder Reactions Yuan-He Li,* Jia-Hua Chen, and Zhen Yang* Chem. Eur. J. 2024. 30(17), e202304371
Total Synthesis of (+)−Haperforin G Zhenyu Zhang, Wei Zhang, Jun−Chen Tang, Jin−Teng Che, Zhongchao Zhang, Jia−Hua Chen,*and Zhen Yang* J. Org. Chem. 2023, 88(15), 10539−10554
Development of a Strategy fot the Total Synthesis of Aspidosperma Alkaloids via the Cyclobutenone-Based PET-Initiated Cationic Radical-Driven [2+2]/Retro-Mannich Reaction Jianyu Long, Rudong Liu, Xinpeng Mu, Zhilin Song, Zhongchao Zhang,* and Zhen Yang* Org. Lett. 2024, 26(15), 2960–2964
Total Synthesis of Penicibilaenes Enabled by a Tandem Double Conia-ene Type Reaction Zheyuan Wang, Zhilin Song, Jun Huang,* and Zhen Yang* J. Am. Chem. Soc.2024, 146(7), 4363–4368
Synthesis towards Phainanoid F: Photo-induced 6π- Electrocyclization for Constructing Contiguous All-Carbon Quaternary Centers Hao-Yuan Liu, Zhen-Yu Zhang, Yi-Ke Zhou, Jia-Hua Chen, Zhen Yang,* and Yuan-He Li* Chem Asian J.2023,18, e20230062
Regioselective Hydroxylation of Flavonoids by Transition-Metal-Catalyzed C−H Bond Oxidation Shu-Min Lu, Chao Chen, Chang Liu, Rudong Liu, Jia-Hua Chen,* Zhongchao Zhang,* and Zhen Yang* Org. Lett. 2023, 25(13), 2264–2269
Highly Stereoselective Diels-Alder Reactions Catalyzed by Diboronate Complexes Yuan-He Li, Su-Lei Zhang, Yong Lu, Bo Xiao, Tian-Yu Sun, Qian-Qian Xu, Jia-Hua Chen,* Zhen Yang* Angew. Chem. Int. Ed.2023, 62(33)
Synthesis of the 5/6 fused-spiro tricyclic framework of manginoid A Zhiming Yan, Chunbo Zhao, Zhen Yang*, Jianxian Gong* Tetrahedron Letters 2023, 117 (2023), 154361-154363
Recent advances in total synthesis of natrual products containing contiguous all carbon quaternary stereocenters Zhongchao Zhang, Zhen Yang * SCIENTIA SINICA Chimica 2023, 53(3), 277-288
Identification and semisynthesis of (−)-anisomelic acid as oral agent against SARS-CoV-2 in mice Hai-Xin Yu, Nan Zheng, Chi-Tai Yeh, Chien-Ming Lee, Qi Zhang, Wen-Lv Zheng, Qing Chang, Yuan-He Li, Yu-Jun Li, Gui-Zhen Wu∗, Jun-Min Quan∗, Lin-Qi Zhang∗, Yew-Min Tzeng∗ and Zhen Yang∗ National Science Review 2022, 9(11), nwac 176
Electrocatalytic Isomerization of Allylic Alcohols: Straightforward Preparation of β-Aryl-Ketones Anding Li, Nan Zheng, Kai Guo, Zhongchao Zhang and Zhen Yang* Catalysts 2022, 12(3), 333
Semisynthesis of (−)-Bufospirostenin A Enabled by Photosantonin Rearrangement Reaction Jun Huang,* Tingting Cao, Zhongchao Zhang, and Zhen Yang* J. Am. Chem. Soc. 2022, 144,(6), 2479–2483
Palladium-Catalyzed Intramolecular Diarylation of 1,3-Diketone in Total Synthesis of (±)-Spiroaxillarone A Tingting Cao, Lei Zhu,* Jun Huang,* and Zhen Yang* Org. Lett. 2022, 24,(7), 1491–1495
Palladium-Catalyzed Intramolecular Diarylation of 1,3-Diketone in Total Synthesis of (±)-Spiroaxillarone A Tingting Cao, Lei Zhu,* Jun Huang,* and Zhen Yang* Org. Lett. 2022, 24,(7), 1491–1495
Total Syntheses of Vicinal Dichloride Monoterpenes Enabled by AzaBellus−̌ Claisen Rearrangement Jiangqun Cheng, Yuan-He Li, Jun Huang,* and Zhen Yang* Org. Lett. 2021, 23(21), 8465–8470
Total Synthesis of (+)-Cyclobutastellettolide B Zhongchao Zhang, Sijia Chen, Fu Tang, Kai Guo, Xin-Ting Liang, Jun Huang,* and Zhen Yang* J. Am. Chem. Soc. 2021, 143,(43), 18287–18293
A Synthetic Route to The Core Structure of (−)-Retigeranic Acid A Xiao Wang, Dian Li, Junlin Zhang, Jianxian Gong, Junkai Fu,* and Zhen Yang* Org. Lett. 2021, 23,(13), 5092–5097
Stereoselective Synthesis of (±)-Cephanolide B Anding Li, Ziru He, Bingyan Liu, Zhen Yang*, and Zichun Zhang* Org. Lett. 2021, 23,(23), 9237–9240
Synthetic Strategy for Construction of Highly Congested Tetracyclic Core (6–5–7–4) of Harziane Diterpenoids Qian Tu, Zheyuan Wang, Zhongchao Zhang, Jun Huang*, and Zhen Yang* Org. Lett. 2021, 23(11), 4088–4093
Stereoselective Synthesis of trans-Decalin-Based Spirocarbocycles via Photocyclization of 1,2-Diketones Sijia Chen, Zhongchao Zhang, Chongguo Jiang, Chunbo Zhao, Haojie Luo, Jun Huang*, and Zhen Yang* ACS Omega 2021, 6(29), 18848–18859
Stereoselective Synthesis of trans-Decalin-Based Spirocarbocycles via Photocyclization of 1,2-Diketones Sijia Chen, Zhongchao Zhang, Chongguo Jiang, Chunbo Zhao, Haojie Luo, Jun Huang*, and Zhen Yang* ACS Omega 2021, 6(29), 18848–18859
Stereoselective Synthesis of Cyclohepta[b]indoles via Visible‐Light‐Induced [2+2]‐Cycloaddition/retro‐Mannich‐type Reactions Xin-Peng Mu, Yuan-He Li, Nan Zheng, Jian-Yu Long, Si-Jia Chen, Bing-Yan Liu, Chun-Bo Zhao, and Zhen Yang* Angew.Chem. Int. Ed. 2021, 60(20), 11211-11216
Navigating the Pauson–Khand Reaction in Total Syntheses of Complex Natural Products Zhen Yang* Acc. Chem. Res. 2021, 54(3), 556–568
Navigating the Pauson–Khand Reaction in Total Syntheses of Complex Natural Products Zhen Yang* Acc. Chem. Res. 2021, 54(3), 556–568
Asymmetric Total Synthesis of (−)-Spirochensilide A, Part 1: Diastereoselective Synthesis of the ABCD Ring and Stereoselective Total Synthesis of 13(R)-Demethyl Spirochensilide A Xin-Ting Liang, Bao-Chuan Sun, Chang Liu, Yuan-He Li, Nan Zhang, Qian-Qian Xu, Zhong-Chao Zhang, Yi-Xin Han, Jia-Hua Chen,* and Zhen Yang* J. Org. Chem. 2021, 86(3), 2135–2157
Synthetic Study Toward the 4,5-Spirocycle Skeleton of Phainanoids Jiang, Chongguo†, Chen, Sijia†, Gong, Jianxian*, Yang, Zhen* Acta Chim. Sinica 2020, 78(9), 928—932
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