李笑宇 - 北京大学 - 化学与分子工程学院

研究领域

生物有机，化学生物学 DNA模板控制技术的发展及模板控制下的有机化学和有机合成；模板控制下的组合化学，药物碎片分子库的合成，相应的高通量筛选；分子探针和药物分子构架设计，构架多样化，以及相关的药物化学；蛋白质组谱分析和小分子蛋白标靶的识别；基于DNA/RNA的分子器件的设计和应用。

近期论文

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Shao-En Ong, Monica Schenone, Adam A. Margolin, Xiaoyu Li, Kathy Do, Mary K. Doud, D. R. Mani, Letian Kuai, Xiang Wang, John L. Wood, Angela N. Koehler, Nicola J. Tolliday, Lisa A. Marcaurelle, Todd R. Golub, Robert J. Gould, Stuart L. Schreiber, and Steven A. Carr, “Identifying the proteins to which small-molecule probes and drugs bind in cells”, Proc. Natl. Acad. Sci. USA. 2009, 106, 4617-4622. Xiaoyu Li and David R. Liu, “DNA-Templated Organic Synthesis: Nature's Strategy for Controlling Chemical Reactivity Applied to Synthetic Molecules”, Angew. Chem. Intl. Ed. Eng., 2004, 43, 4848-4870. This paper is selected as one of the “Best of Angewandte” articles of 2004. Xiaoyu Li, Gartner, Z. J.; Tse, B. N., and David R. Liu, “Translation of DNA into Synthetic N-Acyloxazolidines”, J. Am. Chem. Soc., 2004, 126, 5090-5092. Xiaoyu Li and David R. Liu, “Stereoselectivity in DNA-Templated Organic Synthesis and Its Origins”, J. Am. Chem. Soc., 2003, 125, 10188-10189. Xiaoyu Li and David G. Lynn, “Polymerization on Solid Supports”, Angew. Chem. Intl. Ed. Eng., 2002, 41, 4567-4569. This paper is highlighted as one of the “HOT” papers of the issue. Xiaoyu Li, Zheng-Yun J. Zhan, Rachel Knipe and David G. Lynn, “DNA-Catalyzed Polymerization”, J. Am. Chem. Soc., 2002, 124, 746-747. Ø This paper is reported by Nature Science News (Ball, P. "DNA downloads alone", Nature Science Update, Nature News Service, 05 February 2002). Zheng-Yun J. Zhan, Jingdong Ye, Xiaoyu Li and David G. Lynn, "Replicating DNA Differently", Curr. Org. Chem., 2001, 5, 885-902. Jiaxi Xu, Xiaoyu Li, Zhemin Wang, Qingchuan Yang and Chunhua Yan,, "Methyl (2S)-2-[(5R)-3,5-diphenyl-4,5-dihydro-1,2,4-oxadiazol-4-yl]-3-phenylpropanoate", Acta Crystallography., Section C: Crystal Structure Communication, 1999, C55(4), 650-652.