个人简介

Prof. Heather D. Maynard received a Ph.D. from the California Institute of Technology for research in the group of Nobel Prize winner Robert Grubbs. She then moved to the laboratory of Jeffrey Hubbell at the Swiss Federal Institute of Technology (ETH) and University of Zurich, where from 2000-2002 she was an American Cancer Society Postdoctoral Fellow. Dr. Maynard joined the UCLA faculty as an Assistant Professor in August 2002 as the first Howard Reiss Career Development Chair in the Department of Chemistry and Biochemistry and as a member of the California Nanosystems Institute. Maynard is also a faculty affiliate in the Biomedical Engineering Interdepartmental Program, a member of the Center for Scalable and Integrated Nanomanufacturing, and a member of the Jonsson Comprehensive Cancer Center at UCLA. She is a faculty mentor in several training programs: the Chemistry-Biology Interface, the Materials Creation, the Nanotoxicology Research, and the Biotechnology Training Programs. For the latter she also serves as an executive committee member. Maynard develops new strategies to synthesize protein-polymer conjugates and polymeric drugs. She also creates polymer films for patterning and arraying oriented and bioactive proteins. For her research at UCLA, she has received several awards including the Amgen New Faculty Award, NSF Career Award, the Alfred P. Sloan Fellowship, and the Seaborg Award. She was also selected as an Outstanding Emerging Investigator in Materials Chemistry by the RSC. Maynard has given over eighty invited lectures including the WCC ACS Lecture at Southern Methodist University and the Plenary Lecture at the 9th Annual UNESCO/IUPAC Conference on Macromolecules in South Africa. Maynard has also been selected to participate in symposia sponsored by the US National Academy of Sciences and US National Academy of Engineering.

研究领域

organic/Materials/Nanoscience/Synthesis/Analytical

The Maynard research group creates synthetic approaches to both solution and surface bound biohybrids and explores the application of these nanomaterials in medicine and biotechnology. There are three main research thrusts within the group. (I) Well-defined protein and peptide polymer conjugates are prepared by living/controlled polymerizations. These conjugates are synthesized by polymerizing from proteins and amino acid-reactive initiators and applied as capture agents for proteomics and for wound healing. (II) Homo and block copolymers with reactive side chains are synthesized by controlled radical polymerizations. Click chemistry is exploited to modify the polymers for drug delivery. Inhibition of anthrax toxin and cancer are two of the current targets of interest. (III) Polymer films for conjugation of proteins to surfaces in specific orientation are prepared. Both micron and nano-sized patterns of proteins have been fabricated for use as biomaterial coatings.

近期论文

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Li RC, Broyer RM, Maynard HD Well-Defined Polymers with Acetal Side Chains as Reactive Scaffolds Synthesized by Atom Transfer Radical Polymerization J. Polym. Sci, Part A; Polym. Chem., 2006; 44: 5004-5013. Heredia KL, Maynard HD Aminooxy-Functionalized Semitelechelic Polymers Synthesized by Atom Transfer Radical Polymerization, Polym. Prep., 2005; 46: 593-594. Maynard HD, Hubbell JA Discovery of a Sulfated Tetrapeptide that Binds to Vascular Endothelial Growth Factor Acta Biomaterialia, 2005; 1(4): 451-459. Bontempo D, Maynard HD Protein Macroinitiators for Atom Transfer Radical Polymerization, Polym. Prep., 2005; 46(1): 78-79. Christman KL, Maynard HD Protein Patterning on Polymer Films Using Localized Acid Generation, Polym. Prepr., 2005; 46(2): 1286. Bontempo D, Li RC, Maynard HD Synthesis of Biotinylated Polymers by Atom Transfer Radical Polymerization and Bioconjugate Formation, Polym. Prepr., 2005; 46(2): 435-436. Bontempo D, Heredia KL, Fish BA, Maynard HD Cysteine-reactive polymers synthesized by atom transfer radical polymerization for conjugation to proteins Journal of the American Chemical Society, 2004; 126(47): 15372-3. Hwang J, Maynard HD Multi-Functional Polymers Prepared by RAFT, Polym. Prepr., 2004; 45: 1083-1084. Gunasekaran Karthikeyan, Nguyen Thi H, Maynard Heather D, Davis Thomas P, Bulmus Volga Conjugation of siRNA with Comb-Type PEG Enhances Serum Stability and Gene Silencing Efficiency. Macromolecular rapid communications, 2011; 32(8): 654-9. Christman Karen L, Broyer Rebecca M, Schopf Eric, Kolodziej Christopher M, Chen Yong, Maynard Heather D Protein nanopatterns by oxime bond formation. Langmuir : the ACS journal of surfaces and colloids, 2011; 27(4): 1415-8.