个人简介
谌辉，教授、主任医师、博士生导师。研究方向包括，应用先进的双光子荧光显微镜、神经电生理、转基因、神经示踪、光遗传、化学遗传、光纤光度、分子生物学以及行为学等技术，探讨兴奋性和抑制性神经递质受体以及神经环路在神经及精神性疾病发病中作用机制以及中医药治疗神经及精神性疾病机制。主持国家自然科学基金（重大项目1项、面上项目3项），曾获国家科学技术进步二等奖、湖北省科学技术进步一等奖。在Science和Nature Neuroscience等杂志发表研究论文30多篇。其中Nature Neuroscience为封面论文，同期刊发评论文章，世界主要新闻媒体都报道了研究成果。
研究领域
神经递质受体在神经及精神性疾病发病机制中作用的研究；中药治疗神经及精神性疾病作用机制研究。
近期论文
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1. Shen H,Sabaliauskas N, Sherpa A, Fenton AA, Stelzer A, Aoki C, Smith SS. A Critical Role for α4β2δGABAA Receptors in Shaping Learning Deficits at Puberty in Mice. Science.2010; 327(5972):1515 -8.
2. Shen H, Gong QH, Aoki C, Yuan M, Ruderman Y, Dattilo M, Williams K and Smith SS. Reversal of neurosteroid effects at α4β2δ GABAA receptors triggers anxiety at puberty. Nature Neuroscience. 2007;10(4):469-77.
3. Zheng C, Qiao ZH , Hou MZ, Liu NN, Fu B, Ding R, Li YY, Wei LP, Liu AL and Shen H *. GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Attenuates Cerebral Ischemia Injury In Vivo and Vitro by Differential Modulations of NMDA Receptors Subunit Components at Different Post-Ischemia Stage in Mice. Front. Aging Neurosci., 09 June 2017.| doi.org/10.3389/fnagi.2017.00186.
4. Ding R, Liao X, Li J, Zhang J, Wang M, Guang Y, Qin H, Li X, Zhang K, Liang S, Guan J, Lou J, Jia H, Chen B*, Shen H*, Chen X*. Targeted Patching and Dendritic Ca2+ Imaging in Nonhuman Primate Brain in vivo. Sci Rep. 2017 Jun 6;7(1):2873. doi: 10.1038/s41598-017-03105-0.
5. Zhao R, Chen J, Ren Z, Shen H*, Zhen X*. GSK-3β inhibitors reverse cocaine-induced synaptic transmission dysfunction in the nucleus accumbens. Synapse. 2016 Nov;70(11):461-70. doi: 10.1002/syn.21922. Epub 2016 Jul 22.
6. Xu X, Zheng C, Li N, Shen H*, Wang G*. The decrease of NMDAR subunit expression and NMDAR EPSC in hippocampus by neonatal exposure to desflurane in mice. Behav Brain Res. 2016 Sep 14;317:82-87.
7. Xu YS, Liu NN, Bao XH, Liu B, Shen H*. A Quarter Ellipsoidal Reflector Enhancing Fluorescence Collection Efficiency For Multiphoton Microscopes. IEEE Photonics Journal , 2016 , 8 (5) :1-9.
8. Afroz S, Parato J, Shen H, Smith SS. Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABAA receptors on dendritic spines. Elife. 2016 May 2;5. pii: e15106. doi: 10.7554/eLife.15106.
9. Shen H, Sabaliauskas N, Yang L, Aoki C, Smith SS. Role of α4-containing GABAA receptors in limiting synaptic plasticity and spatial learning of female mice during the pubertal period. Brain Res Special Issue. 2016 Jan 26. pii: S0006-8993(16)00033-0. doi: 10.1016/j.brainres.2016.01.020.
10. Sabaliauskas N#, Shen H#, Molla J, Gong QH, Kuver A, Aoki C, Smith SS. Neurosteroid effects at α4βδ GABAA receptors alter spatial learning and synaptic plasticity in CA1 hippocampus across the estrous cycle of the mouse. Brain Res. 2015 Sep 24;1621:170-86.
11. Shen H, Mohammad A, Ramroop J, Smith SS. A stress steroid triggers anxiety via increased expression of α4βδ GABAA receptors in methamphetamine dependence. Neuroscience. 2013 Dec 19;254:452-75.
12. Shen H, Smith SS. Plasticity of the α4β2δ GABAA receptor. Biochem Soc Trans. 2009; 37: 1378-84.
13. Shen H, Gong QH, Yuan M, Smith SS. Short-term steroid treatment increases delta GABAA receptor subunit expression in rat CA1 hippocampus: pharmacological and behavioral effects. Neuropharmacology. 2005;49(5):573-86.
14. Shen H, Zhang L, Yuen D, Logan R, Jung BP, Zhang G, Eubanks JH. Expression and function of A1 adenosine receptors in the rat hippocampus following transient forebrain ischemia. Neuroscience. 2002;114(3):547-56.
15. Wu C#, Shen H#, Luk WP, Zhang L. A fundamental oscillatory state of isolated rodent hippocampus. J Physiol. 2002; 540( 2): 509-27.
学术兼职
任第8届中国生物医学工程学会理事、中国神经科学学会突触分会委员、中国细胞生物学会神经分会委员、天津市生物医学工程学会副理事长。
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