张涛 - 天津医科大学 - 生物医学工程与技术学院

个人简介

教育背景 1999.9–2004.7 内蒙古科技大学本科 2005.9–2007.7 内蒙古科技大学硕士 2007.9–2011.7 上海交通大学博士工作经历 2013.11–至今天津医科大学生物医学工程与技术学院副教授 2011.07–2013.11 天津医科大学生物医学工程与技术学院讲师荣誉奖励 2013年入选天津市“131”创新型人才第三层次人才 2014年入选天津市“131”创新型人才第二层次人才 2016年被评为天津市教育系统优秀共产党员

研究领域

运用分子动力学模拟方法、生物信息学方法针对细胞色素P450酶单核苷酸多态性对酶活性的影响以及细胞色素P450酶与不同化合物之间的代谢关系进行研究；运用分子动力学模拟方法研究Aβ42寡聚体在膜环境中的构象变化及对于膜的破坏作用机制；构建与疾病相关的蛋白质相互作用网络，并结合miRNA靶点信息从网络调控角度研究miRNA调控蛋白质网络的特性和机制。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1、FengWei , LeiHuimin, SiJiarui , ZhangTao *. Study of structural stability and damaging effect on membrane for four Aβ42 dimers. PLoS ONE，2017， 12(6): e0179147. 2、Wang YF, Zhou Q, Dai H, Zhang Tao*, Wei DQ. Prediction of the functional consequences of single amino-acid substitution in human cytochrome P450. Mol Simulat, 2012,38(14-15):1297–1307. 3、Zhang Tao, Wei Dongqing. Recent progress on structural bioinformatics research of cytochrome P450 and its impact on drug discovery. Adv Exp Med Biol. 2015;827:327-39 4、Zhang Tao, Dai Hao, Liu, LA, Lewis, DFV, Wei, DQ. Classification Models for Predicting Cytochrome P450 Enzyme-Substrate Selectivity. Molecular Informatics. 2012,1,53-62. 5、Zhang Tao, Wei DQ, Chou KC. A pharmacophore model specific to active site of CYP1A2 with a novel molecular modeling explorer and CoMFA. Med Chem, 2012, 8(2):198-207. 6、Zhang Tao, Zhao M, Pang Y, Zhang W, Angela Liu L, Wei DQ. Recent progress on bioinformatics, functional genomics, and metabolomics research of cytochrome P450 and its impact on drug discovery. Curr Top Med Chem. 2012;12(12):1346-55. 7、Zhang Tao, Zhou Q, Pang Y, Wang Y, Jin C, Huo J, Liu LA, Wei D. CYP-nsSNP: a specialized database focused on effect of non-synonymous SNPs on function of CYPs. Interdiscip Sci. 2012 Jun;4(2):83-9 8、Zhang Tao, Limin Angela Liu, Lewis David, Wei Dong-Qing. Long-Range Effects of a Surface Mutation on the Enzymatic Activity of Cytoch 10、Zhang Tao, Gao Yu-Xrome P450 1A2. Journal of Chemical Information and Modeling,2011,51,1336-1346. 9、Zhang Tao, Chen Qi, Li Li, Limin Angela Liu and Wei Dong-Qing. In Silico Prediction of Cytochrome P450-Mediated Drug Metabolism. Combinatorial Chemistry & High Throughput Screening 2011, 14(5):388-395.i, Li Bai, Li Yu-Feng, Cheng Chun-Ying, Wu Gang. Study of Selenium Speciation in Selenized Rice Using High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometer. Chinese Journal of Analytical Chemistry. 2008, 36, 206-210.