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个人简介

韩波,二级教授,博士生导师,成都中医药大学药学院院长,美国纽约州立大学RNA研究所访问学者。入选教育部重大人才工程特聘教授、国家高层次人才特殊支持计划专家、国家中医药管理局“青年岐黄学者”、四川省“天府万人计划”、全国高等中医药院校优秀青年、四川省学术技术带头人、四川省卫生健康领军人才、中国科技期刊卓越行动计划项目—首批青年中医药求真学者、四川省中医药管理局学术技术带头人等。先后荣获四川省政府首届“杰出青年科学技术创新奖”、四川省科技进步一等奖、全国百篇优秀博士论文奖、中华医学青年科技奖、四川省医学科技一等奖、四川省青年科技奖等。

研究领域

研究方向为中药药效物质的结构优化、分子网络机制、多维构效关系和创新药物研发。以临床疗效显著的经典中药药效成分为研究对象,融合多层次的药物结构信息与活性数据,系统研究药效成分“构-效-毒”的多维关系,以此开展药物筛选和创新药物设计开发

近期论文

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Han, B.#; He, X.-H.#; Liu, Y.-Q.; He, G.; Peng, C.*; Li, J.-L.*, Asymmetric organocatalysis: an enabling technology for medicinal chemistry. Chemical Society Reviews, 2021, 50, 1522. (封面文章) Peng, F.#; Liao, M.#; Jin, W.#; Liu, W.#; Li, Z.#; Fan, Z.; Zou, L.; Chen, S.; Zhu, L.; Zhao, Q.; Zhan, G.; Ouyang, L.; Peng, C.; Han, B.*; Zhang, J.*; Fu, L.*, 2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis. Signal Transduction and Targeted Therapy, 2024, 9, 133. Peng, F.#; Liao, M.#; Qin, R.#; Zhu, S.; Peng, C.; Fu, L.*; Chen, Y.*; Han, B.*, Regulated cell death (RCD) in cancer: key pathways and targeted therapies. Signal Transduction and Targeted Therapy, 2022, 7, 286. Liao, M.#; Qin, R.#; Huang, W.; Zhu, H.-P.; Peng, F.*; Han, B.*, Liu, B.*, Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies. Journal of Hematology & Oncology, 2022, 15, 44. Qin, R.; You, F.-M.; Zhao, Q.; Xie, X.; Peng, C.; Zhan, G.; Han, B.*, Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets. Journal of Hematology & Oncology, 2022, 15, 133. Yang, Q.-Q.#; Chen, C.#; Yao, D.#; Liu, W.; Liu, B.*; Zhou, J.; Pan, D.; Peng, C.; Zhan, G.*; Han, B.*, Catalytic Atroposelective Synthesis of Axially Chiral Azomethine Imines and Neuroprotective Activity Evaluation. Angewandte Chemie-International Edition, 2023, 63, e202312663.(封面文章) Li, J.-L.; Liu, Y.-Q.; Zou, W.-L.; Zeng, R.; Zhang, X.; Liu, Y.; Han, B.*; He, Y.; Leng, H.-J.; Li, Q.-Z.* Radical Acylfluoroalkylation of Olefins through N-Heterocyclic Carbene Organocatalysis. Angewandte Chemie-International Edition, 2020, 59, 1863.(封面文章) Han, B.; Xiao, Y.-C.; Yao, Y.; Chen, Y.-C.* Lewis Acid Catalyzed Intramolecular Direct Ene Reaction of Indoles. Angewandte Chemie-International Edition, 2010, 49, 10189. Han, B.; He, Z.-Q.; Li, J.-L.; Li, R.; Jiang, K.; Liu, T.-Y.; Chen, Y.-C.* Organocatalytic Regio- and Stereoselective Inverse-Electron-Demand Aza-Diels–Alder Reaction of α,β-Unsaturated Aldehydes and N-Tosyl-1-aza-1,3-butadienes. Angewandte Chemie-International Edition, 2009, 48, 5474. Han, B.; Li, J.-L.; Ma, S.; Zhang, S.-J.; Chen, Y.-C.* Organocatalytic Asymmetric Inverse-Electron-Demand Aza-Diels-Alder Reaction of N-Sulfonyl-1-aza-1,3-butadienes and Aldehydes. Angewandte Chemie-International Edition 2008, 47, 9971.(封面文章) Wang, B.; Peng, F.; Huang, W.; Zhou, J.; Zhang, N.; Sheng, J.; Haruehanroengra, P.; He, G.*; Han, B.* Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma, Acta Pharmaceutica Sinica B, 2020, 10, 1492. Zhang, J.; Ye, J.; Zhu, S.; Han, B.*; Liu, B.*, Context-dependent role of SIRT3 in cancer. Trends in Pharmacological Sciences, 2024, 45, 173. Li, H.-P.; He, X.-H. Peng, C.; Li, J.L.*; Han, B.* A straightforward access to trifluoromethylated natural products through late-stage functionalization, Natural Product Reports, 2023, 40, 988.(封面文章) Liu, S.-J.; Zhao, Q.; Liu, X.-C.; Gamble, A.-B.; Huang, W.; Yang, Q.-Q.*; Han, B.*, Bioactive atropisomers: Unraveling design strategies and synthetic routes for drug discovery. Medicinal Research Reviews, 2024, doi: 10.1002/med.22037.(封面文章) Wang, J.; Qi, T.; He, S.; Huang, W.; Peng, C.; Zhan, G.*; Han, B.*, Catalyst-Controlled Switchable [5+4]/[3+4] Cycloadditions for the Divergent Synthesis of Pyrazole-Fused Seven- and Nine-Membered Heterocycles. Acs Catalysis, 2023, 13, 10694.(封面文章) Luo, Q.; Tian, Z.; Tang, J.; Wang, J.; Tian Y.; Peng, C.; Zhan, G.*; Han, B.*, Design and Application of Chiral Bifunctional 4‑Pyrrolidinopyridines: Powerful Catalysts for Asymmetric Cycloaddition of Allylic N‑Ylide. ACS Catalysis, 2022, 12, 7221. Zhang, N.#; Zhu, H.-P.#; Huang, W.; Wen, X.; Xie, X.; Jiang, X.; Peng, C.; Han, B.*; He, G.*, Unraveling the structures, functions and mechanisms of epithelial membrane protein family in human cancers. Experimental Hematology & Oncology, 2022, 11, 69. Zuo, W.-F.#; Pang, Q.#; Yao, L.-P.; Zhang, Y.; Peng, C.; Huang, W.*; Han, B.*, Gut microbiota: A magical multifunctional target regulated by medicine food homology species. Journal of Advanced Research, 2023, 52, 151. Peng, F.; Zhao, Q.; Huang, W.; Liu, S.-J.; Zhong, Y.-J.; Mao, Q.; Zhang, N.; He, G.*; Han, B.* Amine-catalyzed and functional group-controlled chemo- and regioselective synthesis of multi-functionalized CF3-benzene via a metal-free process. Green Chemistry 2019, 21, 6179. Zhang, N.; Peng, F.; Wang, Y.; Yang, L.; Wu, F.; Wang, X.; Ye, C.; Han, B.*; He, G.* Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis. International Journal of Biological Sciences 2020, 16, 147. Zhang, X.; Li, Xiang.; Li, J.-L.*; Wang, Q.-W.; Zou, W.-L.; Liu, Y.-Q.; Jia, Z.-Q.; Peng, F.*; Han, B.* Regiodivergent construction of medium-sized heterocycles from vinylethylene carbonates and allylidenemalononitriles. Chemical Science 2020, 11, 2888.(封面文章)

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