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个人简介

教育背景: 2010/09-2014/12,南开大学,环境科学与工程学院环境科学系,理学博士 2011/09-2013/04,美国哈佛大学,公共卫生学院环境卫生系,联合培养博士 2007/09-2010/06,华中农业大学,动物医学院预防兽医学专业,农学硕士 2003/09-2007/06,华中农业大学,生命科学与技术学院生物科学专业,理学学士 工作经历: 2020/06-至今,天津大学应急医学研究院,副研究员,硕士生导师 2015/07-2020/04,天津医科大学公共卫生学院,讲师 科研项目: 1.天津大学温州安全(应急)研究院科研转化项目,TJUWYY2023001,环境污染物与化学物质检测分析服务项目,2022/04-2025/01,1,000,000,在研,主持 2.天津大学温州安全(应急)研究院科研转化项目,TJUWYY2022019,基于线粒体表观遗传学的不良妊娠疾病预警技术研究,2022/01-2023/06, 1,000,000,在研,主持 3.国家自然科学基金面上项目,81971416,血小板mtDNA甲基化与不明原因复发性流产的巢式病例对照研究,2020/01-2023/12,550,000,在研,主持 4.天津大学资助创新基金,2021XZY-0076,作业能力监测维护与提升关键技术研究,2021/01-2021/12,30,000,已结题,主持 5. 国家自然科学基金青年基金,81602827,血小板mtDNA甲基化作为PM暴露的易感性生物标志物的探索性研究,2017/01-2019/12,180,000,已结题,主持 6.天津市自然科学基金青年基金,18JCQNJC11700,线粒体DNA甲基化作为PM2.5暴露致心血管疾病的新型生物标志物的研究,2018/04-2021/03,60,000,已结题,主持 7.天津医科大学基金,2010KY28,青年人群多环芳烃暴露的新型表观遗传标志物研究,2015/12-2017/11,10,000,已结题,主持 8.国家自然科学基金专项项目,81941024,基于遗传与环境交互作用调控线粒体功能对长寿的影响和机制研究,2020/01-2022/12,1,000,000,在研,参加; 9.国家自然科学基金面上项目,81872586,大气污染影响先天性心脏病发生的出生队列研究,2019/01-2022/12,570,000,在研,参加; 10.天津市科技计划项目,18ZXDBSY00190,基于新型标志物“不明原因复发性流产”风险预测模型的建立及评估——前瞻性队列研究,2018/10-2021/09,500,000,在研,参加; 11.国家自然科学基金青年基金,81602826, 出生前DEHP暴露对大鼠下丘脑能量平衡调控的影响及其机制研究,2017/01-2019/12,170,000,在研,参加; 12.国家自然科学基金青年基金,81602850,基于海马Notch信号通路的高脂饮食诱导认知障碍的机制研究,2017/01-2019/12,180,000,在研,参加; 13.国家自然科学基金青年基金,41601548,基于表观遗传学方法评估大气细颗粒物对人体心血管疾病的健康效应,2017/01-2019/12,190,000,在研,参加; 14.天津市自然科学基金青年基金,17JCQNJC10300,天津地区大气环境中有机磷酯阻燃剂的分布特征、来源解析及人群暴露风险评价研究,2017/04-2020/03,60,000,在研,参加;

研究领域

体外诊断技术研究、疾病风险预测、灾难分子流行病学,环境表观流行病学,表观遗传学

近期论文

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Ziquan Liu#, Xuemei Chen#, Huanhuan Cui, Yuxuan Ma, Ning Gao, Xinyu Li, Xiangyan Meng, Huishu Lin, Halidan Abudou, Liqiong Guo*, Qisijing Liu*. Green space exposure on depression and anxiety outcomes: A meta-analysis. Environmental Research, 2023,231,116303. Weixia Li#, Liqiong Guo#, Junkai Fang, Lei Zhao, Shanjun Song, Tao Fang, Chenguang Li, Lei Wang*, Penghui Li*. Phthalates and phthalate metabolites in urine from Tianjin and implications for platelet mitochondrial DNA methylation. Frontiers Public Health, 2023,11:1108555. Jing Wu, Yong Liu, Lijun Peng, Qisijing Liu, Dawei Wang, Xu Jing, Yaozhong Hu, Jing Lin, Hanyue Fu, Xuemeng Ji, Jingmin Liu, Huan Lv, Bo Peng, Bowei Zhang, Liqiong Guo*, Shuo Wang*. A Plasmonic Fluor-lightened Microneedle Array Enables Ultrasensitive Multitarget Whole Blood Diagnosis of Anemia in A Paper Origami-based Device. Small, 2023, e2300464. Yaning Jia#, Weixia Li#, Yanlin Li, Lei Zhao, Chenguang Li, Lei Wang, Junkai Fang, Shanjun Song, Yaqin Ji, Tao Fang, Jing Zhang, Liqiong Guo*, Penghui Li*. The Levels of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Plasma and Their Effect on Mitochondrial DNA Methylation in the Oilfield Workers. Toxics, 2023, 11(5):466. Juan Chen#, Liqiong Guo#, Huimeng Liu, Lei Jin, Wenying Meng, Junkai Fang, Lei Zhao, Xiao-Wen Zeng, Bo-Yi Yang, Qi Wang, Xinbiao Guo, Furong Deng, Guang-Hui Dong, Xuejun Shang*, Shaowei Wu*. Modification effects of ambient temperature on associations of ambient ozone exposure before and during pregnancy with adverse birth outcomes: A multicity study in China. Environment International, 2023, 172:107791. Liqiong Guo#, Huishu Lin#, Hongyu Li, Xiaobin Jin, Lei Zhao, Penghui Li, Naiwei Xu, Song Xu, Junkai Fang, Shaowei Wu*, Qisijing Liu*. Exposure of ambient PM2.5 during gametogenesis period affects the birth outcome: results from the project ELEFANT. Environmental Research, 2023, 220:115204. Huishu Lin, Qisijing Liu, Lei Zhao, Ziquan Liu, Huanhuan Cui, Penghui Li, Haojun Fan* and Liqiong Guo*. Circulating Pulmonary-Originated Epithelial Biomarkers for Acute Respiratory Distress Syndrome: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2023, 24, 6090. Qisijing Liu#, Jing Wang#, Chixuan Yao#, Lu Yang, Lei Zhao, Liqiong Guo, Jing-Min Liu, Shuo Wang*. Functional micro-/nanostructures in agrofood science: precise inspection, hazard elimination, and potential health risks. Journal of Agricultural and food chemistry, 2023, 71(2):1018-1034. Liqiong Guo#, Yanhua Wang#, Xueli Yang, Ting Wang, Jingjing Yin, Lei Zhao, Yang Lin, Yufei Dai, Shike Hou*, Huawei Duan*. Aberrant mitochondrial DNA methylation and declined pulmonary function in a population with polycyclic aromatic hydrocarbon composition in particulate matter. Environmental Research, 2022, 214: 113797. Liqiong Guo#, Ziquan Liu#, Penghui Li*, Yaqin Ji*, Shanjun Song, Na Zheng, Lei Zhao, Yaning Jia, Junkai Fang, Huiyu Wang, Hyang-Min Byun. Association between mitochondrial DNA methylation and internal exposure to polycyclic aromatic hydrocarbons (PAHs), nitrated-PAHs (NPAHs) and oxygenated-PAHs (OPAHs) in young adults from Tianjin, China. Ecotoxicology and Environmental Safety, 2022, 241: 113799. Jing Zhang#, Ziquan Liu#, Shanjun Song, Junkai Fang, Lei Wang, Lei Zhao, Chenguang Li, Weixia Li, Hyang-Min Byun, Liqiong Guo*, Penghui Li*. The exposure levels and health risk assessment of antibiotics in urine and its association with platelet mitochondrial DNA methylation in adults from Tianjin, China: A preliminary study. Ecotoxicology and Environmental Safety, 2022, 231: 113204. Juan Chen#, Peng-Hui Li#, Haojun Fan, Chen Li, Ying Zhang, Duan Ju, Furong Deng, Xinbiao Guo, Liqiong Guo*, Shaowei Wu*. Weekly-specific ambient fine particular matter exposures before and during pregnancy were associated with risks of small for gestational age and large for gestational age: results from Project ELEFANT. International Journal of Epidemiology, 2022, 51(1):202-212. Xinying Shui#, Lei Zhao#, Wenli Li, Yaning Jia, Ziquan Liu, Chen Li, Xueli Yang, Haoran Huang, Shouling Wu, Shuohua Chen, Jingli Gao, Xiaolan Li, Aitian Wang, Xiaobin Jin, Liqiong Guo*, Shike Hou*. Association between exposure to earthquake in early life and diabetes mellitus incidence in adulthood with the modification of lifestyles: Results from the Kailuan study. Frontiers in Pediatrics, 2022, 10:1046086. Juan Chen, Shaowei Wu, Junkai Fang, Ziquan Liu, Xuejun Shang, Xinbiao Guo, Furong Deng*, Liqiong Guo*. Association of exposure to fine particulate matter wave over the preconception and pregnancy periods with adverse birth outcomes: Results from the project ELEFANT. Environmental Research, 2021, 205:112473. Ziquan Liu#, Huanhuan Cui#, Lei Zhao, Fucai Ma, Yanqing Liu, Yuansen Chen, Jiale Chen, Yaning Jia, Wenli Li, Jinxia Cai, Xun Bi, Penghui Li, Haojun Fan, Liqiong Guo*, Shike Hou*. Effects of plateau air quality and low oxygen content on platelet mtdna methylation and high altitude pulmonary edema. Aerosol and Air Quality Research, 2021, 21(12):210222. Bibo Yuan#, Citlalli Osorio-Yáñez#, Junkai Fang, Lei Zhao, Ander Wilson, Marco Sanchez-Guerra, Hongbin Liu, Peng-Hui Li*, Liqiong Guo*. Effect of Radiation, Organic Solvents and Vibration Occupational Exposure on the Thyroid Disease: Results from Project ELEFANT. Aerosol and Air Quality Research, 2021, 21(9), 210085. Qisijing Liu, Hongyu Li, Liqiong Guo, Qiao Chen, Xu Gao, Peng-hui Li, Naijun Tang, Xinbiao Guo, Furong Deng*, Shaowei Wu*. Effects of short-term personal exposure to air pollution on platelet mitochondrial DNA methylation levels and the potential mitigation by L-arginine supplementation. Journal of Hazardous Materials, 2021, 417:125963. Duan Ju, Xiaozhou Li, Yunfang Shi, Yanhong Ma, Liqiong Guo, Yanli Wang, Ruiyu Ma, Yuanyue Zhong, Ying Zhang*, Fengxia Xue*. Evaluation of the practical applications of fluorescence in situ hybridization in the prenatal diagnosis of positive noninvasive prenatal screenings. The Journal of Maternal-Fetal & Neonatal Medicine. 2021, 417: 125963. Lei Zhao, Shanjun Song, Penghui Li*, Jing Liu, Jing Zhang, Lei Wang, Yaqin Ji, Jinpeng Liu*, Liqiong Guo, Jinbao Han. Fine particle-bound PAHs derivatives at mountain background site (Mount Tai) of the North China: Concentration, source diagnosis and health risk assessment. Journal of Environmental Sciences, 2021, 109: 77-87. Juan Chen, Junkai Fang, Ying Zhang, Zhouyang Xu, Hyang-Min Byun, Peng-hui Li, Furong Deng, Xinbiao Guo, Liqiong Guo*, Shaowei Wu*. Associations of adverse pregnancy outcomes with high ambient air pollution exposure: Results from the Project ELEFANT. Science of the Total Environment, 2021, 761, 143218. Junkai Fang, Choong-Min Kang, Citlalli Osorio-Yáñez, Timothy M.Barrow, Ruiping Zhang, Ying Zhang, Chen Li, Hongbin Liu, Peng-hui Li, Liqiong Guo*, Hyang-Min Byun, Prenatal PM2.5 Exposure and the Risk of Adverse Births Outcomes: Results from Project ELEFANT. Environmental Research, 2020, 191, 110232. Timothy M. Barrow, Cheng Peng, Ander Wilson, Hao Wang, Hongbin Liu, Lilin Shen, Nai-jun Tang, Chanachai Sae-Lee, Peng-hui Li, Liqiong Guo*, Hyang-Min Byun, Psychosocial stress is associated with benign breast disease in young Chinese women: results from Project ELEFANT. Breast Cancer Research and Treatment, 2019, 173: 217-224. Peng-hui Li*, Hong-yan Jia, Yan Wang, Tao Li, Lei Wang, Qian-qian Li, Min-min Yang, Jun-jie Yue, Xian-liang Yi, Li-qiong Guo*, Characterization of PM2.5-bound phthalic acid esters (PAEs) at regional background site in northern China: Long-range transport and risk assessment. Science of the Total Environment, 2019, 659:140-149. Liqiong Guo#*, Cheng Peng#, Hui Xu#, Ander Wilson, Peng-hui Li, Hao Wang, Hongbin Liu, Lilin Shen, Xi Chen, Xiuying Qi, Nai-jun Tang, Timothy M. Barrow, Hyang-Min Byun, Age at menarche and prevention of hypertension through lifestyle in young Chinese adult women: result from project ELEFANT. BMC Women's Health, 2018, 18: 182. Hui Xu#, Peng-hui Li#, Timothy M. Barrow, Elena Colicino, Changping Li, Ruixue Song, Hongbin Liu, Nai-jun Tang, Songyan Liu, Liqiong Guo*, Hyang-Min Byun, Obesity as an effect modifier of the association between menstrual abnormalities and hypertension in young adult women: Results from Project ELEFANT. Plos One, 2018, 13(11): e0207929. Liqiong Guo#*, Peng-hui Li, Hua Li, Elena Colicino, Silvia Colicina, Yi Wen, Ruiping Zhang, Xiaotian Feng, Timothy M. Barrow, Akin Cayir, Andrea A. Baccarelli, Hyang-Min Byun. Effect of environmental noise exposure on DNA methylation in the brain and metabolic health. Environmental Research. 2017; 153:73-82. Timothy M. Barrow, Hyang-Min Byun, Xinyan Li, Chris Smart, Yong-Xiang Wang, Yacong Zhang, Andrea A. Baccarelli, Liqiong Guo*, The effect of morphine upon DNA methylation in ten regions of the rat brain. Epigenetics, 2017, 12: 1038-1047.

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