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个人简介

学习经历 1981~1986,天津医科大学,预防医学,学士学位 1986~1989,天津医科大学,营养与食品卫生学,硕士学位 2005~2009,天津科技大学,食品科学,博士学位 工作经历 2018.04至今 天津医科大学营养与食品卫生学系教授,系主任 2005~2018 天津医科大学营养与食品卫生学教研室系教授,系主任,院长 2003~2004 加拿大西安大略大学医学院客座教授 2000~2005 天津医科大学公共卫生学院营养研究室教授,副院长 1995~2000 天津医科大学公共卫生学院营养研究室副教授 1989~1995 天津医科大学公共卫生学院营养与食品卫生学教研室助教、讲师

研究领域

营养与疾病,营养与神经科学

近期论文

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Xinyan Wang, Wen Li, Zhenshu Li, Yue Ma, Jing Yan, John X. Wilson and Guowei Huang*. Maternal Folic Acid Supplementation During Pregnancy Promotes Neurogenesis and Synaptogenesis in Neonatal Rat Offspring. Cerebral Cortex. 2018 Aug 23. doi: 10.1093/cercor/bhy207. [Epub ahead of print]. Shanshan Cui, Xin Lv, Wen Li, Zhenshu Li, Huan Liu, Yuxia Gao*, Guowei Huang*. Folic acid modulates VPO1 DNA methylation levels and alleviates oxidative stress-induced apoptosis in vivo and in vitro. Redox Biology. 2018 Aug 8; 19:81-91. Xinyan Wang, Wen Li, Shou Li, Jing Yan, John X. Wilson, Guowei Huang*. Maternal Folic Acid Supplementation During Pregnancy Improves Neurobehavioral Development in Rat Offspring. Mol Neurobiol. 2018, Mar 9, 55(3), 2676-2684. Wen Li, Zhenshu Li, Shou Li, Xinyan Wang, John X. Wilson, Guowei Huang*. Periconceptional Folic Acid Supplementation Benefit to Development of Early Sensory-Motor Function through Increase DNA Methylation in Rat Offspring. Nutrients. 2018, 10(3), 292. Ma F, Li Q, Zhou X, Zhao J, Song A, Li W, Liu H, Xu W, Huang G*. Effects of folic acid supplementation on cognitive function and Aβ-related biomarkers in mild cognitive impairment: a randomized controlled trial. Eur J Nutr. 2017 Dec 18. doi: 10.1007/s00394-017-1598-5. [Epub ahead of print] Jing Yan, Yuyan Liu, Lujia Cao, Yuzhi Zheng, Wen Li, Guowei Huang*. Association between Duration of Maternal Folic Acid Supplementation and Postpartum Depression. Nutrients. 2017 Nov 2;9(11). pii: E1206. Fei Ma, Tianfeng Wu, Jiangang Zhao, Lu Ji, Aili Song, Meilin Zhang, Guowei Huang*. Plasma Homocysteine and Serum Folate and Vitamin B12 Levels in Mild Cognitive Impairment and Alzheimer’s disease: A Case-control Study. Nutrients. 2017 Jul 8;9(7). pii: E725. Shanshan Cui, Wen Li, Xin Lv, Pengyan Wang, Yuxia Gao*, Guowei Huang*. Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro. Intl J Mol Sci. 2017 May 5;18(5): 990. Fei Ma, Tianfeng Wu, Jiangang Zhao, Fengmei Han, Anna Marseglia, Huan Liu, Guowei Huang*. Effects of six-month folic acid supplementation on cognitive function and blood biomarkers in Mild Cognitive Impairment: a randomized controlled trial in China. J Gerontol A Biol Sci Med Sci. 2016 Oct;71(10):1376-83. Wen Li, Huan Liu, Min Yua, Xumei Zhanga, Yan Zhangb, Hongbo Liub, John X. Wilsonc, Guowei Huang*. Folic acid alters methylation profile of JAK-STAT and long-term depression signaling pathways in Alzheimer's disease models. Mol Neurobiol. 2016 Nov;53(9):6548-6556. Meilin Zhang, Li Zheng, Ping Li, Yufeng Zhu, Hong Chang, Xuan Wang, Weiqiao Liu, Yuwen Zhang, Guowei Huang*. 4-year trajectory of visceral adiposity index in the development of type 2 diabetes: a prospective cohort study. Ann Nutr Metab 2016;69:142-149. Xuan Wang, Mingyue Zhang, Guang Lui, Hong Chang, Meilin Zhang, Wei Liu, Ziwei Li, Yixin Liu, Guowei Huang*. Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis. Nutrients, 2016 Aug 13;8(8). pii: E497. Hui Chen, Shuai Liu, Lu Ji, Tianfeng Wu, Yong Ji, Yuying Zhou, Miaoyan Zheng, Meilin Zhang, Weili Xu, Guowei Huang*. Folic acid supplementation mitigates Alzheimer’s disease by reducing inflammation: a randomized controlled trial. Mediators Inflamm. 2016;2016:5912146. Huan Liu, Wen Li, Shijing Zhao, Xumei Zhang, Meilin Zhang, Yanyu Xiao, John X. Wilson, Guowei Huang*. Folic acid attenuates the effects of amyloid β oligomers on DNA methylation in neuronal cells. Eur J Nutr. 2016 Aug;55(5):1849-62. Meilin Zhang, Ping Li, Yufeng Zhu, Hong Chang, Xuan Wang, Weiqiao Liu, Yuwen Zhang, Guowei Huang*. Higher visceral fat area increases the risk of vitamin D insufficiency and deficiency in Chinese adults. Nutrition & Metabolism. 2015 Nov 25;12:50. Wen Li, Mingyue Jiang, Shijing Zhao, Huan Liu, Xumei Zhang, John X Wilson, Guowei Huang*. Folic Acid Inhibits Amyloid β-Peptide Production through Modulating DNA Methyltransferase Activity in N2a-APP Cells. Intl J Mol Sci. 2015 Oct 20, 16, 25002-25013. Meilin Zhang, Yufeng Zhu, Ping Li, Hong Chang, Xuan Wang, Weiqiao Liu, Yuwen Zhang, Guowei Huang*. Associations between Dietary Patterns and Impaired Fasting Glucose in Chinese Men: A Cross-Sectional Study. Nutrients. 2015 Sep 21;7(9):8072-89. Huan Liu, Tian Tian, Shanchun Qin, Wen Li, Xumei Zhang, Xuan Wang, Yuxia Gao, Guowei Huang*. Folic acid deficiency enhances abeta accumulation in APP/PS1 mice brain and decreases amyloid-associated miRNAs expression. J Nutr Biochem. 2015 Dec; 26(12):1502-8. Wen Li, Huan Liu, Min Yu, Xumei Zhang, Meilin Zhang, John X. Wilson, Guowei Huang*. Folic acid administration inhibits amyloid β-peptide accumulation in APP/PS1 transgenic mice. J Nutr Biochem. 2015 Aug, 26(8):883-891. (IF: 4.414,5-years IF: 4.669) Hui Chen, Shuai Liu, Lu Ji, Tianfeng Wu, Fei Ma, Yong Ji, Yuying Zhou, Miaoyan Zheng, Meilin Zhang, Guowei Huang*. Associations between Alzheimer’s Disease and Blood Homocysteine, Vitamin B12, and Folate: A Case-Control Study. Curr Alzheimer Res. 2015, 12(1):88-94. Fei Ma, Tianfeng Wu, Rujuan Miao, Yan yu Xiao, Wenwen Zhang, Guowei Huang*. Conversion of Mild Cognitive Impairment to Dementia among Subjects with Diabetes: a Population-based Study of Incidence and Risk Factors with Five Years of Follow-up. J Alzheimers Dis. 2015,43(4):1441-1449. Wen Li, Mingyue Jiang, Yanyu Xiao, Xumei Zhang, Shanshan Cui, Guowei Huang*. Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells. J Nutr Health Aging. 2015 Feb;19(2):123-9. Jing Yan, Lin Liu, Yun Zhu, Guowei Huang*, Peizhong Peter Wang*. The association between breastfeeding and childhood obesity: a meta-analysis. BMC Public Health 2014, 14:1267.

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