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个人简介

教育背景 1994年-1997年 协和医科大学,医科院肿瘤所,分子肿瘤学国家重点实验室,细胞生物学,博士 1991年-1994年 天津医科大学,基础部,病理学,硕士 1986年-1991年 天津医科大学,医学系,临床医学,学士 工作经历 2016- 天津医科大学基础医学院遗传学系教授、系副主任 2011年- 天津医科大学基础医学研究中心PI, 病理学教授 2011年-2014年 天津市特聘教授 2003年-2010年 美国宾夕法尼亚大学(University of Pennsylvania), 医学院,精神医学系(Department of Psychiatry), Research Assistant Professor of Genetics in Psychiatry (研究助理教授) 2000年-2003年 美国宾夕法尼亚大学(University of Pennsylvania), 医学院, Research Associate 1997年-2000年 美国宾夕法尼亚大学(University of Pennsylvania), 医学院,博士后 荣誉奖励 1. 1999年美国人类遗传学会学生奖候选(final list) 2. 1999年获“天衡杯”肿瘤研究论文奖 3. 1998年天津市科技进步奖(三等) 人胰腺癌组织微卫星DNA改变与肿瘤临床特征的相关性研究 李伟、王殿昌、李卫东、郝希山、王秀琴 4. 1994年天津市科技进步奖(三等) 人乳头状瘤病毒16型聚合酶链反应检测试剂盒的研制 张维铭、汤华、王芝芬、余虹、李卫东

研究领域

遗传流行病学和肿瘤遗传学

近期论文

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1. Wang L, Li WD, Wang XQ, Zhang CL, Zhang T, Mao XZ and Wu M: Genetic alterations on chromosomes 3 and 9 of esophageal cancer tissues from China. Oncogene, 1996,12: 699-703. 2. Li WD, Wang XQ, Zhang CL, Han X, Chen D, Zhang T, Mao X, and Wu M. Esophageal carcinoma in part of population of Yangquan City. National Medical Journal of China. 1998, 78(3):203-206. (in Chinese) 3. Lee JH, Reed DR, Li WD, Xu W, Joo E-J, Kilker RL, Nanthakumar E, North M, Sakul H, Bell C, Price RA. Genome scan for human obesity and linkage to markers in 20q13. American Journal of Human Genetics 1999;64(1):196-209. 4. Li WD, Reed DR, Lee JH, Xu W, Kilker RL, Sodam BR, Price RA. Sequence variants in the promotor and 5’ flanking region of the leptin gene are associated with obesity in women. Annals of Human Genetics 1999,63:227-234. 5. Li WD, Joo EJ, Furlong EB, Galvin M, Abel K, Bell CJ and Price RA. Melanocortin 3 receptor (MC3R) gene variants in extremely obese women. International Journal of Obesity 2000,24:206-210. 6. Zhang W, Bailey-Wilson JE, Li WD, Wang X, Zhang C, Mao X, Liu Z, Zhou C and Wu M. Segregation analysis of esophageal cancer in a moderate high-incidence area of northern China. American Journal of Human Genetics 2000,67:110-119. 7. Li WD, Lee JH, Price RA. The peroxisome proliferator-activated receptor 2 Pro12Ala mutation is associated with early onset extreme obesity and reduced fasting glucose. Molecular Genetics and Metabolism.2000,70:159-161. 8. Price RA, Li WD, Bernstein A, Crystal A, Golding EM, Weisberg SJ, Zuckerman WA and Joseph R. A locus affecting obesity (BMI  27 kg/m2) is confirmed in human chromosome 10p12. Diabetologia. 2000,44:363-366. 9. Price RA, Li WD and Kilker R. An X-chromosome scan reveals a locus for fat distribution in chromosome region Xp21-22. Diabetes. 2002,51:1989-1991. 10. Dong C, Wang S, Li WD, Zhao H and Price RA. Interacting Genetic Loci on Chromosome 20 and 10 Influence Extreme Human Obesity. American Journal of Human Genetics 2003,72:115-124 11. Li WD, Li D, Wang S, Zhang S, Zhao H and Price RA. Linkage and linkage disequilibrium mapping of genes influencing human obesity in chromosome region 7q22.1-7q35. Diabetes. 2003, 52: 1557-1561. 12. Li WD, Dong C, Ding L, Zhao H and Price RA. An obesity related locus in chromosome region 12q23-24. Diabetes. 2004, 53: 812-820. 13. Li WD, Dong C, Ding L and Price RA. A quantitative trait locus influencing fasting plasma glucose in chromosome region 18q22-23. Diabetes, 2004, 53:2487-2491. 14. Dong C, Li WD, Ding L and Price RA. Interaction between obesity-susceptibility loci in chromosome regions 2p25-p24 and 13q13-q21. European Journal of Human Genetics, 2005, 13: 102-108. 15. Li WD, Dong C, Ding L, Garrigan C and Price RA. A genome scan for serum triglyceride in obese nuclear families. J Lipid Res, 2005, 46: 432-438. 16. Dong C, Li WD, Geller F, Lei L, Li D, Gorlova OY, Hebebrand J, Amos CI, Nicholls RD and Price RA. Possible Genomic Imprinting of Three Human Obesity-Related Genetic Loci. Am J Hum Genet. 2005, 76: 427-437. 17. Dong C, Li WD, Li D and Price RA. Extreme obesity is associated with attempted suicides: results from a family study. International Journal of Obesity. 2006, 30:388-390. 18. Malhotra A, Coon H, Feitosa MF, Li WD, North KE, Price RA, Bouchard C, Hunt SC, Wolford JK and The American Diabetes Association GENNID Study Group. Meta-analysis of genome-wide linkage studies for quantitative lipid traits in African Americans. Human Molecular Genetics. 2005, 14:3955-62 19. Price RA, Li WD, and Zhao H. FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. BMC Medical Genetics, 2008, 9:4 20. Wang K, Li WD, Glessner JT, Grant SFA, Hakonarson H and Price RA. Large copy number variations are enriched in cases with moderate to extreme obesity. Diabetes, 2010, 59: 2690-94.

学术兼职

天津市医学会遗传咨询分会副主任委员 中国优生科学协会常务理事、教育工作委员会副主任委员 中华医学会医学遗传学分会细胞与基因组学专委会委员 美国心脏病学会(AHA)动脉粥样硬化和血管病专业委员会委员 美国人类遗传学会(ASHG) 会员 美国糖尿病学会(ADA)会员 北美肥胖研究学会(NAASO)会员

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