个人简介
教育背景
2001.09–2005.07，四川大学, 生物技术, 学士
2005.09–2011.07，中科院上海生命科学院, 生物化学及分子生物学,博士
工作经历
2018.01-至今, 天津医科大学, 基础医学院, 教授，PI
2015.12-2017.12, 上海交通大学, 医学院－第一人民医院，Co-PI
2013.09-2015.11, 美国费城儿童医院转化医学中心, 博士后
2011.03-2013.08, 美国宾夕法尼亚大学医学院, 博士后
荣誉奖励
上海市卫计委优青
近期论文
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1)Wang T#* (共通讯), Yu Q#, Li J, Hu B, Zhao Q, Ma C, Huang W, Zhuo L, Fang H, Liao L, Eugene Chin Y, Jiang Y. O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency. Nature Cell Biology, 2017.7, 19(7): 833~+
2)Wang T#, Liu J#, McDonald C, Lupino K, Zhai X, Wilkins BJ, Hakonarson H, Pei L. GDF15 is a heart-derived hormone that regulates body growth. EMBO Molecular Medicine, 2017.8, 9(8): 1150~1164
3)Chen T#, Wang T#, Liang W, Zhao Q, Yu Q, Ma C, Zhuo L, Guo D, Zheng K, Zhou C, Wei S, Huang W, Jiang J, Liu J, Li S, He J, Zhong N and Jiang Y. PAK4 phosphorylates fumarase and blocks TGF-β-induced cell growth arrest in lung cancer cells. Cancer Research, 2019.1, pii: canres.2575.2018.
4)Wang T#, McDonald C, Petrenko NB, Leblanc M, Wang T, Giguere V, Evans RM, Patel VV, Pei L. Estrogen-related receptor alpha (ERRα) and ERRɣ are essential coordinators of cardiac metabolism and function. Mol Cell Biol, 2015.4, 35(7): 1281~1298
5)Wang T#, Yanger K, Stanger BZ, Cassio D, Bi E. Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation. J Cell Sci, 2014.6.1, 127(Pt 11): 2483~2492
6)Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX, Huang S, Lu Z. PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells. Nat Commun, 2014, 5: 5566~5566
7)Li J, Hu B, Wang T, Huang W, Ma C, Zhao Q, Zhuo L, Zhang T, Jiang Y. C-Src confers resistance to mitotic stress through inhibition DMAP1/Bub3 complex formation in pancreatic cancer. Mol Cancer. 2018 Dec 15;17(1):174.
8)Wang T#, Yu Q, Chen J, Deng B, Qian L, Le Y. PP2A mediated AMPK inhibition promotes HSP70 expression in heat shock response. PLoS One. 2010 Oct 1;5(10).
9)Li Z, Mou H, Wang T, Xue J, Deng B, Qian L, Zhou Y, Gong W, Wang JM, Wu G, Zhou CF, Fang J, Le Y. A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression. Cancer Lett, 2013.1.28, 328(2): 278~284
10)Yu Q, Wang T, Jiang Y. The decisive role of fumarase: Responsive signaling to glucose deficiency. Mol Cell Oncol. 2018 May 16;5(4):e1363848.
11)Yu Q, Wang T, Zhou X, Wu J, Chen X, Liu Y, Wu D, Zhai Q. Wld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NAD. PLoS One. 2011;6(7)
12)Wang O, Cai K, Pang S, Wang T, Qi D, Zhu Q, Ni Z, Le Y. Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells. Endocrinology. 2008 Feb;149(2):672-80.
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