余鹰 - 中国科学院上海营养与健康研究所 -

个人简介

2017-至今天津医科大学基础医学院药理学系,教授 2017-至今中国科学院上海营养与健康研究所研究员 2009-2016年中国科学院上海生命科学研究院营养科学研究所,研究员 2008 -2009年美国宾夕法尼亚大学，心血管疾病动物模型中心主任 2006-2009年美国宾夕法尼亚大学医学院转化医学研究所,Research Associate 2002-2006年美国宾夕法尼亚大学医学院药理系,博士后 1998-2001年中南大学湘雅医学院病理生理系，病理生理学博士 1995-1998年南昌大学医学院病理生理学教研室，病理生理学硕士 1990-1995年南昌大学医学院临床医学系，学士

研究领域

1，利用转基因小鼠结合易感人群分析研究环氧合酶（COX），Ω－3/脂肪酸（EPA和DHA）和前列腺素产物在心脏重塑与血管损伤中作用 2，前列腺素及其受体在糖脂代谢与糖尿病并发血管性疾病中作用

近期论文

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Zuo S, Kong D, Wang C, Liu J, Wang Y, Wan Q, Yan S, Zhang J, Tang J, Zhang Q, Lyu L, Li X, Shan Z, Qian L, Shen Y*, Yu Y*. CRTH2 promotes endoplasmic reticulum stress-induced cardiomyocyte apoptosis through m-calpain. EMBO Mol Med. 2018 Jan 15. pii: e8237. doi: 10.15252/emmm.201708237 Chen G, Zuo S,Tang J,Zuo C,Jia D,Liu Q, Liu G,n Zhu Q, Wang Y, Zhang J, Shen Y, Che D, Yuan P, Qin Z, Ruan C,Ye J, Wang XJ, Zhou Y, Gao P, Zhang P, Liu J,Jing ZC, Lu A, Yu Y* . Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice. J Exp Med. 2018, In press. Tang J, Shen Y, Chen G, Wan Q, Wang K, Zhang J, Qin J, Liu G, Zuo S, Tao B, Yu Y, Wang J, Lazarus M, Yu Y*. Activation of E-prostanoid 3 receptor in macrophages facilitates cardiac healing after myocardial infarction. Nat Commun. 2017;8:14656. Yan S, Tang J, Zhang Y, Wang Y, Zuo S, Shen Y, Zhang Q, Chen D, Yu Y, Wang K, Duan S*, Yu Y*. Prostaglandin E2 Promotes Hepatic Biliary Cholesterol Excretion by E Prostanoid Receptor 3 Mediated Hepatocyte Nuclear Receptor 4α/Cholesterol 7α-Hydroxylase Pathway in Mice. Hepatology. 2017,65(3):999-1014. Li J, Kong D, Wang Q, Wu W, Tang Y, Bai T, Guo L, Wei L, Zhang Q, Yu Y, Qian Y, Zuo S, Liu G, Liu Q, Wu S, Zang Y, Zhu Q, Jia D, Wang Y, Yao W, Ji Y, Yin H, Nakamura M, Lazarus M, Breyer RM, Wang L*, Yu Y*. Niacin ameliorates ulcerative colitis via prostaglandin D2-mediated D prostanoid receptor 1 activation. EMBO Mol Med. 2017;9(5):571-588. Kong D, Shen Y, Liu G, Zuo S, Ji Y, Lu A, Nakamura M, Lazarus M, Stratakis CA, Breyer RM, Yu Y*. PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation. J Exp Med. 2016;213(10):2209-26. Shen Y, Zuo S, Wang Y, Shi H, Yan S, Chen D, Xiao B, Zhang J, Gong Y, Shi M, Tang J, Kong D, Lu L, Yu Y, Zhou B, Duan SZ, Schneider C, Funk CD, Yu Y*. Thromboxane governs the differentiation of adipose-derived stromal cells toward endothelial cells in vitro and in vivo. Circ Res. 2016 Apr 15;118(8):1194-207. Lu A, Zuo C, He Y, Chen G, Piao L, Zhang J, Xiao B, Shen Y, Tang J, Kong D, Alberti S, Chen D, Zuo S, Zhang Q, Yan S, Fei X, Yuan F, Zhou B, Duan S, Yu Y, Lazarus M, Su Y, Breyer RM, Funk CD, Yu Y*. EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling. J Clin Invest. 2015; 125(3):1228-42. Shi M, Shi G, Tang J, Kong D, Bao Y, Xiao B, Zuo C, Wang T, Wang Q, Shen Y, Wang H, Funk CD, Zhou J*, Yu Y*. Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyper-responsiveness. J Allergy Clin Immunol. 2014;134(5):1163-74. Yang Q, Shi M, Shen Y, Cao Y, Zuo S, Zuo C, Zhang H, Gabrilovich DI, Yu Y*, Zhou J*. COX-1 derived thromboxane A2 plays an essential role in early B cell development via regulation of JAK/STAT5 signaling in mouse. Blood. 2014;124(10):1610-21. Yan S, Zhang Q, Zhong X, Tang J, Wang Y, Yu J, Zhou Y, Zhang J, Guo F, Liu Y, FitzGerald GA, Yu Y*. I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT. Diabetes. 2014 Sep;63(9):2911-23 Zhang J, Zou F, Tang J, Zhang Q, Gong Y, Wang Q, Shen Y, Xiong L, Breyer RM, Lazarus M, Funk CD, Yu Y*. COX-2-Derived PGE2 Promotes Injury-induced Vascular Neointimal Hyperplasia through the the E-prostanoid 3 receptor. Circ Res. 2013; 113(2):104-14.