个人简介
教育背景
1999年9月-2004年6月 华中科技大学同济医学院
2004年9月-2009年1月 北京协和医学院基础医学研究所
工作经历
2014年3月至今 天津医科大学基础医学院
2009年1月-2013年12月 丹麦哥本哈根大学生物科技与创新中心
荣誉奖励
2016至今 天津市“131”创新型人才培养工程第一层次人选
2018至今 天津市特聘教授
2018至今 天津市创新推进计划中青年领军人才
近期论文
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1. Gong Y*, Yue J*, Wu X, Wang X, Wen J, Lu L, Peng X, Qiang B, Yuan J. NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element. Nucleic Acids Research 2006; 34(21):6158-6169
2. Wu X, Gong Y, Yue J, Qiang B, Yuan J, Peng X. Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing. Nucleic Acids Research 2008; 36(11): 3590-3599.
3. Wu X, Johansen VJ, Helin K. Fbxl10/Kdm2b recruits Polycomb Repressive Complex 1 to CpG-islands and regulates H2A ubiquitylation. Molecular Cell 2013; 49(6): 1134-1146. (COVER)
4. Klauke K, Radulovic V, Mathilde J.C. Wu X, Helin K, Bystrykh L, de Haan G. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation. Nature Cell Biology 2013; 15(4): 353-362. (COVER)
5. Liu Y, Carlsson R, Comabella M, Wang J, Wu X, et al., FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS. Nature Medicine 2014; 20(3): 272-282.
6. Rissing E.M*, Comet I*, Wu X, Helin K. Gene silencing triggers Polycomb Repressive Complex 2 recruitment to CpG islands genome-wide. Molecular Cell 2014; 55(3): 347-360.
7. Sidoli S, Schwämmle V, Ruminowicz, C, Hansen TA, Wu X, Helin K and Jensen O.N. Middle-down hybrid chromatography/tandem mass spectrometry workflow for characterization of combinatorial post-translational modifications in histones. Proteomics 2014; 14(19): 2200-2211.
8. Ueda T, Nagamachi A, Takubo K, Yamasaki N, Matsui H, Kanai A, Nakata Y, Ikeda K, Konuma K, Oda H, Wolff L, Honda Z, Wu X, Helin K, Honda H. Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2.Blood2015; (22): 3437-3446.
9. Wu X#, Pedersen I, Christensen J, Rasmussen, Williams K, Cui Y, Xiao Z, Qi Y, Rappsilber J, Winther O, Helin K#. Tumor Suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals. Cell Research2015; 25(11): 1205-1218 (# corresponding author).
10. Yin J, Leavenworth JW, Li Y, Wu X, Orkin S, Cantor H and Wang X. Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity. Proc Natl Acad Sci U S A 2015; 112(52): 15988-15993.
11. Schwammle V, Sidoli S, Ruminowicz C, Wu X, Lee CF, Helin K and Jensen, ON. Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation. Mol Cell Proteomics 2016; 15(8), 2715-2729. 12. Zhao X, Wang X, Li Q, Wu X#. FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway.Cell Death Dis 2018; 9(2): 46
13. Zheng G, Guan B, Hu P, Li R, Wu X*, Sui L*. Topographical Cues of Direct Metal Laser Sintering Titanium Surfaces Facilitate Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells through Epigenetic Regulation. Cell Proliferation 2018; e12460. (COVER)
14. Kong Y, Ai Q, Dong F, Xia X, Zhao X, Yang C, Kang C, Zhou Y, Zhao Q*, Sun X, Wu X*. Targeting of BMI-1 with PTC-209 inhibits glioblastoma development. Cell cycle 2018; 17(10): 1199-1211.
15. Dong F, Li Q#, Yang C#, Huo D, Wang X, Ai C, Kong Y, Sun X, Wang W, Zhou Y, Liu X, Li W, Gao W, Liu W, Kang C*, Wu X*. PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma. Nat Comm 2018; 9(1): 4552.
16. Liu Z, Ma S, Lu X, Sui L, Wu X*, Zhang X*, Gao P*. Reinforcement of epithelial sealing around titanium dental implants by chimeric peptides. Chem Eng J doi: 10.1016/j.cej.2018.09.004
17. Huang K, Liu X#, Wang Q#, Zhou J, Wang Y, Sun Z, Fang C, Tan Y, Wu X*, Jiang T*, Kang C*. Genome-wide CRISPR-Cas9 screening identifies NF-κB/E2F6 responsible for EGFRvIII-associated Temozolomide resistance in GBM. Adv Sci. doi: 10.1002/advs.201900782.
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