辛灵彪 - 天津医科大学

个人简介

教育背景 2013/09-2016/06，天津医科大学，博士，医学细胞生物学 2011/09-2013/09，天津医科大学，硕士，免疫学 2007/09-2011/07，天津科技大学，学士，生物工程工作经历 2017.7至今，天津医科大学基础医学院生物化学与分子生物学系，中级，讲师

研究领域

卵巢肿瘤；胚胎及发育

近期论文

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(1) Lingbiao Xin#, Ran Zhao#, Jing Lei, Jianchan Song, Lin Yu, Ru Gao, Chuanbo Ha, Yuanyuan Ren, Xin Liu, Yixin Liu, Zhi Yao*, Jie Yang*#, SND1 acts upstream of SLUG to regulate the epithelial-mesenchymal transition (EMT) in SKOV3 cells, FASEB journal, (2018) fj201801728R. (2) Xinting Wang#, Lingbiao Xin, Zhongchao Duan, Zhiyu Zuo, Yuan Wang, Yuanyuan Ren, Wei Zhang, Xiaoming Sun, Xin Liu, Lin Ge, Xi Yang, Zhi Yao*, Jie Yang*, Global Tudor-SN transgenic mice are protected from obesity-induced hepatic steatosis and insulin resistance, FASEB journal, (2018) fj201801253RR. (3) Xiao Fu#, Chunyan Zhang#, Hao Meng#, Kai Zhang, Lei Shi, Cheng Cao, Ye Wang, Chao Su, Lingbiao Xin, Yuanyuan Ren, Wei Zhang, Xiaoming Sun, Lin Ge, Olli Silvennoinen, Zhi Yao, Xi Yang*, Jie Yang*, Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress, Cell Death & Differentiation, 25 (2018) 1625-1637. (4) Chao Su#, Xingjie Gao#, Wendong Yang#, Yali Zhao, Xue Fu, Xiaoteng Cui,Chunyan Zhang, Lingbiao Xin, Yuanyuan Ren, Lixin Li, Wenqing Shui, Xi Yang, Minxin Wei*, Jie Yang*, Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules, Biochim Biophys Acta, 2017;1864 (3):562-571 (5) Lin Yu#, Yanbo Di#, Lingbiao Xin, Yuanyuan Ren, Xin Liu, Xiaoming Sun, Wei Zhang, Zhi Yao*, Jie Yang*, SND1 acts as a novel gene transcription activator recognizing the conserved Motif domains of Smad promoters, inducing TGFβ1 response and breast cancer metastasis, Oncogene, 2017 Jul 6;36(27):3903-3914 (6) Lingbiao Xin#, Xue Fu#, Xiaoteng Cui, Jinyan He, Olli Silvennoinen, Zhi Yao, Minxin Wei, Xi Yang, Jie Yang, Xingjie Gao*, Lin Ge*, Sub-cellular localization of Tudor-SN foci under different stress conditions, Int J Clin Exp Pathol.2016;9(4) (7)Lin Yu#, Xin Liu#, Kang Cui, Yanbo Di, Lingbiao Xin, Xiaoming Sun, Wei Zhang, Xi Yang, Minxin Wei, Zhi Yao* Jie Yang*, SND1 acts downstream of TGFβ1 and upstream of Smurf1 to promote breast cancer metastasis, 2015, Cancer Res, 2015 Apr 1;75(7): 1275-86 (8) Xingjie Gao#, Xue Fu#, Juan Song#, Yi Zhang, Xiaoteng Cui, Chao Su, Lin Ge, Jie Shao, Linbiao Xin, Saarikettu J, Mei Mei, Xi Yang, Minxin Wei, Olli Silvennoinen, Zhi Yao, Jinyan He, Jie Yang*, Poly(A)(+) mRNA-binding protein Tudor-SN regulates stress granules aggregation dynamics, FEBS J, 2015 Mar; 282(5): 874-90 (9 )Zhongchao Duan#, Xiujuan Zhao#, Xiao Fu, Chao Su, Lingbiao Xin, Juha Saarikettu, Xi Yang ,Zhi Yao, Olli Silvennoinen, MinxinWei*, Jie Yang*, Tudor-SN, a Novel Coactivator of Peroxisome Proliferator activated Receptor γ Protein, Is Essential for Adipogenesis, J. Biol. Chem, 2014, 289: 8364-8374 (10)哈传博#，赵然，雷静，高茹，杨洁，辛灵彪*, 同义突变SND1慢病毒质粒的构建及回复表达 [J]. 生物技术, 2018, 28 (4). 329-334. (11)杨扬#，白虹，辛灵彪*:，卵巢癌细胞系OVCAR3过表达SND1稳定株的构建 [J]. 天津医科大学学报，2018, 24(1), 7-9. (12)辛灵彪#，高星杰，付雪，张毅，史雪彬，陈朴，尹洁，何津岩，杨洁*, 重组真核质粒pEGFP-C2-hTudor-SN-SN(1~4)的构建及表达 [J]. 医学分子生物学杂志, 2012, 9(4). 241-245.