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个人简介

教育背景 2000年9月至2003年6月 南开大学化学学院 博士 1997年9月至2000年6月 南开大学化学学院 硕士 1992年9月至1996年6月 南开大学化学学院 本科 工作经历 2014-今 天津医科大学 基础医学院生物化学与分子生物学系 教授 2012-2013 南开大学 药物化学生物学国家重点实验室 PI 2011-2011 美国芝加哥大学 访问学者 2008-2013 南开大学 化学学院 副教授 2006-2008 美国德克萨斯大学西南医学中心 博士后 2004-2006 美国华盛顿州立大学 博士后 2003-2004 法国国家科研中心 CNRS-7575(巴黎)博士后

研究领域

蛋白质组学和肿瘤生物学

近期论文

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(1) Dong, H.Y., Zhai, G. J., Chen, C., Bai, X., Tian, S. S., Hu, D.Q., Fan, E. G., Zhang, K.* (2019) Protein lysine de-2-hydroxyisobutyrylation by CobB in prokaryote, Science Advances, 5: eaaw6703. (2) An, J.Y., Zhai, G.J.*, Guo, Z.C., Bai, X., Chen, P., Dong, H.Y., Tian, S.S., Ai, D., Zhang, Y.K., and Zhang, K.* (2019) Combinatorial Peptide Ligand Library-Based Photoaffinity Probe for the Identification of Phosphotyrosine-Binding Domain Proteins. Analytical Chemistry 91, 3221-3226. (3) Zhai, G., Dong, H., Guo, Z., Feng, W., Jin, J., Zhang, T., Chen, C., Chen, P., Tian, S., Bai, X., Shi, L., Fan, E., Zhang, Y., and Zhang, K.* (2018) An Efficient Approach for Selective Enrichment of Histone Modification Readers Using Self-Assembled Multivalent Photoaffinity Peptide Probes. Analytical Chemistry 90, 11385-11392 (4) Bai, X., Bi, W. J., Dong, H. Y., Chen, P., Tian, S. S., Zhai, G. J., and Zhang, K.* (2018) An Integrated Approach Based on a DNA Self-Assembly Technique for Characterization of Crosstalk among Combinatorial Histone Modifications. Analytical Chemistry 90, 3692-3696 (5) Dong, H. Y., Guo, Z. C., Feng, W., Zhang, T., Zhai, G. J., Palusiak, A., Rozalski, A., Tian, S. S., Bai, X., Shen, L. J., Chen, P., Wang, Q., Fan, E. G., Cheng, Z. Y., and Zhang, K.* (2018) Systematic Identification of Lysine 2-hydroxyisobutyrylated Proteins in Proteus mirabilis. Mol Cell Proteomics 17, 482-494 (6) Shen, L., Chen, C., Guo, Z., Zhai, G., Dong, H., Li, M., Zhang, K.* (2018) Abnormal expression of proteins in human renal mesangial cells stimulated by high levels of uric acid. Int J Clin Exp Med 9, 9434-9440. (7) Su, D. X., Ma, S., Shan, L., Wang, Y., Wang, Y. J., Cao, C., Liu, B. B., Yang, C., Wang, L. Y., Tian, S. S., Ding, X., Liu, X. H., Yu, N., Song, N., Liu, L., Yang, S. D., Zhang, Q., Yang, F. Q., Zhang, K., and Shi, L. (2018) Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis. Journal of Clinical Investigation 128, 4280-4296 (8) He, J. L., Bao, Q. K., Zhang, Y., Liu, M. M., Lv, H. Z., Liu, Y. J., Yao, L., Li, B. C., Zhang, C. H., He, S., Zhai, G. J., Zhu, Y., Liu, X., Zhang, K., Wang, X. J., Zou, M. H., Zhu, Y., and Ai, D. (2018) Yes-Associated Protein Promotes Angiogenesis via Signal Transducer and Activator of Transcription 3 in Endothelial Cells. Circulation Research 122, 591-605 (9) Bi, C., Liang, Y., Shen, L., Tian, S., Zhang, K., Li, Y., He, X., Chen, L., and Zhang, Y. (2018) Maltose-Functionalized Hydrophilic Magnetic Nanoparticles with Polymer Brushes for Highly Selective Enrichment of N-Linked Glycopeptides. ACS Omega 3, 1572-1580 (10) Yang, S. D., Liu, L., Cao, C., Song, N., Wang, Y. J., Ma, S., Zhang, Q., Yu, N., Ding, X., Yang, F. Q., Tian, S. S., Zhang, K., Sun, T., Yang, J., Yao, Z., Wu, S. Y., and Shi, L. (2018) USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization. Nature Communications 9, 1285 (11) Fu, X., Zhang, C. Y., Meng, H., Zhang, K., Shi, L., Cao, C., Wang, Y., Su, C., Xin, L. B., Ren, Y. Y., Zhang, W., Sun, X. M., Ge, L., Silvennoinen, O., Yao, Z., Yang, X., and Yang, J. (2018) Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. Cell Death and Differentiation 25, 1625-1637 (12) Gao, D., Wang, L., Zhang, H., Yan, X., Yang, J., Zhou, R., Chang, X., Sun, Y., Tian, S., Yao, Z., Zhang, K., Liu, Z., and Ma, Z. (2018) Spleen tyrosine kinase SYK(L) interacts with YY1 and coordinately suppresses SNAI2 transcription in lung cancer cells. FEBS J, doi: 10.1111/febs.14665 (13) Gao, J., Yang, Y., Qiu, R., Zhang, K., Teng, X., Liu, R., and Wang, Y. (2018) Proteomic analysis of the OGT interactome: novel links to epithelial-mesenchymal transition and metastasis of cervical cancer. Carcinogenesis 39, 1222-1234 (14) Qiu, R. F., Shi, H., Wang, S., Leng, S., Liu, R. Q., Zheng, Y., Huang, W., Zeng, Y., Gao, J., Zhang, K., Hou, Y. Q., Feng, D. D., and Yang, Y. (2018) BRMS1 coordinates with LSD1 and suppresses breast cancer cell metastasis. Am J Cancer Res 8, 2030-2045 (15) Tian, S. S., Zheng, S. Z., Han, Y. P., Guo, Z. C., Zhai, G. J., Bai, X., He, X., Fan, E. G., Zhang, Y. K., and Zhang, K.* (2017) Maleic Anhydride Labeling-Based Approach for Quantitative Proteomics and Successive Derivatization of Peptides. Analytical Chemistry 89, 8259-8265 (16) Bi, W., Bai, X., Gao, F., Lu, C., Wang, Y., Zhai, G., Tian, S., Fan, E., Zhang, Y., and Zhang, K.* (2017) DNA-Templated Aptamer Probe for Identification of Target Proteins. Analytical Chemistry 89, 4071-4076 (17) Lu, C. C., Tian, S. S., Zhai, G. J., Yuan, Z. F., Li, Y. J., He, X. W., Zhang, Y. K., and Zhang, K.* (2017) Probing the Binding Interfaces of Histone-Aptamer by Photo Cross-Linking Mass Spectrometry. ACS Chemical Biology 12, 57-62 (18) He, J. Z., Wu, Z. Y., Wang, S. H., Ji, X., Yang, C. X., Xu, X. E., Liao, L. D., Wu, J. Y., Li, E. M., Zhang, K.*, and Xu, L. Y.* (2017) A decision tree based combination of ezrin-interacting proteins to estimate the prognostic risk of patients with esophageal squamous cell carcinoma. Hum Pathol 66, 115-125 (19) Lin, L. H., Xu, Y. W., Huang, L. S., Hong, C. Q., Zhai, T. T., Liao, L. D., Lin, W. J., Xu, L. Y., Zhang, K., Li, E. M., and Peng, Y. H. (2017) Serum proteomic-based analysis identifying autoantibodies against PRDX2 and PRDX3 as potential diagnostic biomarkers in nasopharyngeal carcinoma. Clinical Proteomics 14, doi: 10.1186/s12014-017-9141-5 (20) Mu, Y., Yan, X., Li, D., Zhao, D., Wang, L., Wang, X., Gao, D., Yang, J., Zhang, H., Li, Y., Sun, Y., Wei, Y., Zhang, Z., Chang, X., Yao, Z., Tian, S., Zhang, K., Terada, L. S., Ma, Z., and Liu, Z. (2017) NUPR1 maintains autolysosomal efflux by activating SNAP25 transcription in cancer cells. Autophagy, 1-17

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