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个人简介

教育背景 1986.09-1992.07:中山医科大学 临床医学系,临床医学专业,学士学位 1992.09-1997.07:中山医科大学 生化教研室,生物化学专业,博士学位 工作经历 2015.07-今: 天津医科大学基础医学院生物化学-分子生物学系主任(教授,博导) 2010.07-今: 天津医科大学基础医学研究中心分子免疫学实验室(PI,教授,博导) 2010.04-2015.07: 天津医科大学基础医学院院长(教授,博导) 2005.07-2010.04: 天津医科大学 基础医学院副院长(教授,博导) 2003.09-2005.07: 天津医科大学基础医学院免疫学教研室副主任(教授) 1998.12-2003.09: 坦佩雷大学医学技术研究所分子免疫实验室(博士后) 1997.07-1998.12: 中山医科大学生化教研室(讲师) 荣誉奖励 1.2004年国家教育部新世纪人才支持计划 2.2005年度天津医科大学留学生教学优秀教师 3.2007年度天津市优秀教师 4.2008年卫生部有突出贡献中青年专家 5.2008年天津市特聘教授 6.2008年天津市131人才第一层次 7.2009年天津市优秀留学回国人员 8.2011年国家杰出青年基金获得者 9.2012年荣获第十一届天津青年科技奖 10.2012年天津市优秀科技工作者 11.2012年入选天津市高校“学科领军人才培养计划” 12.2013年教育部创新团队带头人 13.2014年中国侨界创新人才

研究领域

细胞信号传导通路调控、肿瘤发生机制

近期论文

查看导师最新文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.Fu X, Zhang C, Meng H, Zhang K, Shi L, Cao C, Wang Y, Su C, Xin L, Ren Y, Zhang W, Sun X, Ge L, Silvennoinen O, Yao Z, Yang X, Yang J*. Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. Cell Death Differ. 2018 Sep;25(9):1625-1637. 2. Li X, Ruan X, Zhang P, Yu Y, Gao M, Yuan S, Zhao Z, Yang J*, Zhao L*. TBX3 promotes proliferation of papillary thyroid carcinoma cells through facilitating PRC2-mediated p57KIP2 repression, oncogene 2018 May;37(21):2773-2792. 3.Cui X, Zhao C, Yao X, Qian B, Su C, Ren Y, Yao Z, Gao X, Yang J*. SND1 acts as an anti-apoptotic factor via regulating the expression of lncRNA UCA1 in hepatocellular carcinoma. RNA Biol. 2018;15(10):1364-1375. 4.Xin L, Zhao R, Lei J, Song J, Yu L, Gao R, Ha C, Ren Y, Liu X, Liu Y, Yao Z, Yang J*. SND1 acts upstream of SLUG to regulate the epithelial-mesenchymal transition (EMT) in SKOV3 cells. FASEB J. 2018 Dec 3. doi: 10.1096/fj.201801728R. [Epub ahead of print] 5.Wang X, Xin L, Duan Z, Zuo Z, Wang Y, Ren Y, Zhang W, Sun X, Liu X, Ge L, Yang X, Yao Z. Yang, J*. Global Tudor-1 SN transgenic mice are protected from obesity-induced hepatic steatosis and insulin resistance. FASEB J. 2018 Dec 6. doi: 10.1096/fj.201801253RR. [Epub ahead of print] 6.Yu L, Di Y, Xin L, Ren Y, Liu X, Sun X, Zhang W, Yao Z, Yang J*. SND1 acts as a novel gene transcription activator recognizing the conserved Motif domains of Smad promoters, inducing TGFbeta1 response and breast cancer metastasis. Oncogene, 2017; 36(27):3903-3914. 7.Su C, Gao X, Yang W, Zhao Y, Fu X, Cui X, Zhang C, Xin L, Ren Y, Li L, Shui W, Yang X, Wei M, Yang J*. Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules. Biochim Biophys Acta-Mol Cell Res. 2017;1864 (3):562-571. 8.Fu X, Gao X, Ge L, Cui X, Su C, Yang W, Sun X, Zhang W, Yao Z, Yang X, Yang J*. Malonate induces the assembly of cytoplasmic stress granules. FEBS Lett 2016; 590(1):22-33. 9.Yu L, Liu X, Cui K, Di Y, Xin L, Sun X, Zhang W, Yang X, Wei M, Yao Z, Yang J*. SND1 acts downstream of TGFβ1 and upstream of Smurf1 to promote breast cancer metastasis. Cancer Res. 2015; 75(7):1275-1286. 10.Su C, Zhang C, Tecle A, Fu X, He J, Song J, Zhang W, Sun X, Ren Y, Silvennoinen O, Yao Z, Yang X, Wei M, Yang J*. Tudor Staphylococcal Nuclease (Tudor-SN), a Novel Regulator Facilitating G1/S Phase Transition, Acting As a Co-activator of E2F-1 in Cell Cycle Regulation. J Biol Chem. 2015; 290(11):7208-7220. 11.Gao X, Fu X, Song J, Zhang Y, Cui X, Su C, Ge L, Shao J, Xin L, Saarikettu J, Mei M, Yang X, Wei M, Silvennoinen O, Yao Z, He J, Yang J*. Poly(A)+ mRNA-binding protein Tudor-SN regulates stress granules aggregation dynamics. FEBS J. 2015;282(5):874-890. 12.Fu X, Gao X, Ge L, Cui X, Su C, Yang W, Sun X, Zhang W, Yao Z, Yang X, Yang J*. Malonateinduces the assembly of cytoplasmic stress granules. FEBS Lett 2016; 590(1):22-33. 13.Duan Z, Zhao X, Fu X, Su C, Xin L, Saarikettu J, Yang X, Yao Z, Silvennoinen O, Wei M, Yang J*. Tudor-SN, a Novel Coactivator of Peroxisome Proliferator-Activated Receptorγ Protein, is Essential for Adipogenesis. J Biol Chem. 2014; 289(12):8364-8374. 14.Gao X, Shi X, Fu X, Ge L, Zhang Y, Su C, Yang X, Silvennoinen O, Yao Z, He J, Wei M, Yang J*. Human Tudor staphylococcal nuclease (Tudor-SN) protein modulates the kinetics of AGTR1-3'UTR granule formation. FEBS Lett. 2014;588(13):2154-2161. 15.Zhang Y, Gao X, Zhi L, Liu X, Jiang W, Sun Y, Yang J*. The synergetic antibacterial activity of Ag islands on ZnO (Ag/ZnO) heterostructure nanoparticles and its mode of action. J Inorg Biochem. 2014;130:74-83. 16.Zhou Y, Zuo D, Wang M, Zhang Y, Yu M, Yang J*, Yao Z*. Effect of truncated neurokinin-1 receptor expression changes on the interaction between human breast cancer and bone marrow-derived mesenchymal stem cells. Genes Cells. 2014 Sep;19(9):676-691. 17.Zhou Y, Zhao L, Xiong T, Chen X, Zhang Y, Yu M, Yang J*, Yao Z*. Roles of full-length and truncated neurokinin-1 receptors on tumor progression and distant metastasis in human breast cancer. Breast Cancer Res Treat. 2013 Jul;140(1):49-61. 18.Zhao X, Duan Z, Liu X, Wang B, Wang X, He J, Yao Z, Yang J*. MicroRNA-127 is Downregulated by Tudor-SN Protein and Contributes to Metastasis and Proliferation in Breast Cancer Cell Line MDA-MB-231. Anat Rec (Hoboken). 2013 Dec;296(12):1842-1849. 19.Yin J, Ding J, Huang L, Tian X, Shi X, Zhi L, Song J, Zhang Y, Gao X, Yao Z, Jing X, Yang J*. SND1 affects proliferation of hepatocellular carcinoma cell line SMMC-7721 by regulating IGFBP3 expression. Anat Rec (Hoboken). 2013 Oct;296(10):1568-1575. 20.Gao X, Zhao X, Zhu Y, He J, Shao J, Su C, Zhang W, Zhang W, Saarikettu J, Silvennoinen O, Yao Z, Yang J*. Tudor Staphylococcal Nuclease (Tudor-SN) participates in small ribonucleoprotein (snRNP) assembly via interacting with symmetrically dimethylated Sm proteins. J. Biol. Chem. 2012; 287: 18130-18141.

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