个人简介

B.S., Harvard University (1967); Ph.D., University of Chicago (1970); NSF Postdoctoral Fellow, University of Paris-Orsay (1971); Miller Institute Fellow, University of California, Berkeley (1971-1972); Alfred P. Sloan Research Fellow (1974); Camille and Henry Dreyfus Teacher-Scholar Award (1976); Glenn T. Seaborg Award (1981); Hanson-Dow Distinguished Teaching Award (1986); American Physical Society Fellow (1987); Herbert Newby McCoy Award (1988); Brotherton Professor, University of Leeds (1988); Royal Society of Chemistry/Lennard-Jones Medal (1991); University Distinguished Teaching Award (1996); J. S. Guggenheim Fellowship (1998-1999); Rothschild Professor, Institut Curie, Paris (1999); American Chemical Society "Liquids" (Hildebrand) Prize (2001).

研究领域

Biophysics/Physical/Theory/Theoretical Chemistry

I am generally interested in the statistical mechanics of complex fluids. "Complex" here refers to the fact that the systems in question possess at least one degree of freedom beyond the usual translational one in "simple" fluids. In the case of neat liquid crystals, for example, it is the possibility of long-range orientational order which enters; in the instance of flexible polymers, it is the conformational degrees of freedom. Even more intriguing are the self-assembling systems such as micellized surfactant solutions, where the interacting colloidal particles are aggregates of large numbers of molecules. Because of the exchange of molecules between micelles, the sizes and shapes of these aggregates are not fixed but rather vary with concentration and temperature. Accordingly, a new statistical mechanical approach is necessary to describe the resulting complexity of structures and phase coexistences in these solutions. Complex fluids also involve the appearance of a new ("mesoscopic") length scale, intermediate between molecular and macroscopic. In surfactant solutions and microemulsions it is "simply" the size of the self-assembled structures (e.g., micelles and oil-in-water domains respectively), while more generally it is associated with the wavelength of various spatially modulated phases which emerge spontaneously at low enough temperatures. Finally, we continue to work on statistical mechanical approaches to the response to applied stress and strain of almost-ideal solids (i.e., ones free of all but small (atomic) -scale defects), concentrating in particular on crystal-crystal phase transitions, amorphization, and -- ultimately -- failure via melting or fracture.

近期论文

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Knobler, C. M. Gelbart, W. M. Physical chemistry of DNA viruses Annu Rev Phys Chem, 2009; 60: 367-83. Gelbart WM, Knobler CM Presssurized Viruses Science, 2009; 323(5922): 1682-1683. Prinsen P, Fang LT, Yoffe AM, Knobler CM, Gelbart WM The Force Acting on a Polymer Partially confined in a Tube J Phys Chem B, 2009; 113(12): 3873-3879. Chang, C. B. Knobler, C. M. Gelbart, W. M. Mason, T. G. Curvature dependence of viral protein structures on encapsidated nanoemulsion droplets ACS Nano, 2008; 2(2): 281-6. Evilevitch, A., Fang, L.-T., Yoffe, A. M., Castelnuovo, M., Rau, D. C., Parsegian, Gelbart W. M. and Knobler,. C. M. Effects of Salt Concentrations and Bending Energy on the Extent of Ejection of Phage Genomes Biophys. J., 2008; 94(3): 1110-1120. Ng, B.C.; Yu, M.; Gopal, A.; Rome, L.H.; Monbouquette, H.G.; and Tolbert, S.H. Encapsulation of Semiconducting Polymers in Vault Protein Cages Nano Letters, 2008; 8(10): 3503?3509. Hu, Y. Zandi, R. Anavitarte, A. Knobler, C. M. Gelbart, W. M. Packaging of a polymer by a viral capsid: the interplay between polymer length and capsid size Biophys J, 2008; 94(4): 1428-36. Yoffe, A. M. Prinsen, P. Gopal, A. Knobler, C. M. Gelbart, W. M. Ben-Shaul, A. Predicting the sizes of large RNA molecules Proc Natl Acad Sci U S A, 2008; 105(42): 16153-8. Knobler, C.M. and W.M. Gelbart The Physics of Phages Physics Today, 2008; 61(1): 42-47.