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个人简介

教育背景 1980.09-1985.07 河北中医学院中医专业本科毕业 获学士学位 1985.09-1988.07 天津中医学院硕士研究生毕业 获医学硕士学位 1999.04-2003.03 日本东邦大学医学部攻读病理专业博士研究生,获医学博士学位 工作经历 2004.10- 至今 天津医科大学基础医学院生理与病理生理学学系 教授 2003.06-2004.09 天津医科大学基础医学院生理与病理生理学学系 副教授 1998.08-1999.03 日本东邦大学医学部 研修 1994.10 -1995.09 获笹川医学奖学金在日本东邦大学医学部 访问学者 1988.08-1998.07 天津中医学院中医系 助教、讲师 荣誉奖励 1. 2008年天津医科大学优秀教师 2. 2009年天津市三八红旗集体负责人 3. 2011年天津医科大学优秀党务工作者 4. 2011年天津医科大学先进基层党组织负责人 5. 2012年天津市教育系统创先争优优秀共产党员

研究领域

动脉粥样硬化的发病机制

近期论文

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1.Zheng N#, Zhang L#, Wang B#, Wang G, Liu J, Miao G, Zhao X, Liu C, Han P, Zhang L*.Chlamydia pneumoniae infection promotes vascular smooth muscle cell migration via c-Fos/interleukin-17C signalingChlamydia pneumoniae infection promotes vascular smooth muscle cell migration via c-Fos/interleukin-17C signaling. Int J Med Microbiol.DOI information: ‪10.1016‬/j.ijmm.‪2019.151340‬. 2.Liu J, Miao G, Wang B, et al. Chlamydia pneumoniae infection promotes monocyte transendothelial migration by increasing vascular endothelial cell permeability via the tyrosine phosphorylation of VE-cadherin [J]. Biochemical and biophysical research communications, 2018, 497(2):742-748.(Correspondence author) 3. Wang B, Zhang L, Liu J, Ma L, Wang H, Zheng N, Chen X, Shen B, Xu Z, Zhang L*. Chlamydia pneumoniae infection promotes vascular endothelial cell angiogenesis through an IQGAP1-related signaling pathway. Int J Med Microbiol 2017; Jun;307:276-286 (Correspondence author) 4. Ma L, Zhang L, Wang B, Wei J, Liu J, Zhang L*. Berberine inhibits Chlamydia pneumoniae infection-induced vascular smooth muscle cell migration through downregulating MMP3 and MMP9 via PI3K. Eur J Pharmacol 2015; Mar;755:102-9 (Correspondence author) 5. Zhang J, Wang H, Zhang L, Zhang T, Wang B, Li X, Wei J, Zhang L*. Chlamydia pneumoniae infection induces vascular smooth 1 muscle cell migration via Rac1 activation. J Med Microbiol 2014;63:155-161 (Correspondence author) 6. Wang B, Zhang L, Zhang T, Wang H, Zhang J, Wei J, Shen B, Liu X, Xu Z, Zhang L*. Chlamydia pneumoniae infection promotes vascular smooth muscle cell migration through Toll-like receptor 2-related signaling pathway. Infect Immun 2013;81(12):4583-91 (Correspondence author) 7. Zhang L, Li X, Zhang L*, Wang B, Zhang T, Ye J. Chlamydophila (Chlamydia) pneumoniae infection promotes vascular smooth muscle cell adhesion and migration through IQ domain GTPase-activating protein 1. Microb Pathog 2012;53(5-6):207-213 (Correspondence author) 8. Zhang L, Zhang L*, Quan W, Wang B, Shen B, Zhang T, Kang Y. Berberine inhibits HEp-2 cell invasion induced by Chlamydophila pneumoniae infection. J Microbiol 2011;49(5):834-840 (Correspondence author) 9. Luo Y, Hu W, Xu R, Hou B, Zhang L, Zhang W. ZNF580, a novel C2H2 zinc finger transcription factor, interacts with TGF-β signal molecule SMAD2. Cell Biol Int 2011;35(11):1153-1157. 10. Zhang L, Ishikawa Y, Akasaka Y, Ito K, Gregory S, Ishii T. Limited association of Chlamydia pneumoniae detection with coronary atherosclerosis. Atherosclerosis 2003;167:81-88. 11. Zhang L, Ishikawa Y, Akasaka Y, Ito K, Ishii T. Enigmatic relationship between Chlamydia pneumoniae and atherosclerosis. Pathol In. 2003;53:733-734. 12. Akishima Y, Akasaka Y, Ishikawa Y, Zhang L, Ito K, Kiguchi H, Itabe H, Ishii T. Role of macrophage and smooth muscle cell apoptosis in association with oxidized low-density lipoprotein in the atherosclerotic development. Mod Pathol 2005;18(3):365-373. 13. Akishima Y, Ito K, Zhang L, Ishikawa Y, Orikasa H, Kiguchi H, Akasaka Y, Komiyama K, Ishii T. Immunohistochemical detection of human small lymphatic vessels under normal and pathological conditions using the LYVE-1 antibody. Virchows Arch 2004;444:153-157. 14. Ishikawa Y, Akasaka Y, Ishii T, Murakami MY, Miura NC, Tomita M, Ito K, Zhang L, Akishima Y, Ishiharu M, Muramatsu M, Taniyama M. Changes in the distribution pattern of gelatin-binding protein of 28 kDa (adiponectin) in myocardial remodeling after ischaemic injury. Histopathology 2003;42:43-52. 15. Ishikawa Y, Sekiguchi K, Akasaka Y, Ito K, Akishima Y, Zhang L, Itoh M, Ishihara M, Ishii T. Fibromuscular dysplasia of coronary arteries resulting in myocardial infarction associated with hypertrophic cardiomyopathy in Noonan's syndrome. Human Pathology 2003;34(3):282-284. 16. Ishikawa Y, Ito K, Akasaka Y, Ishii T, Masuda T, Zhang L, Akishima Y, Kiguchi H, Nakajima K, Hata Y. The distribution and production of cholesteryl ester transfer protein in the human aortic wall. Atherosclerosis 2001;156:29-37. 17. Akasaka Y, Fujita K, Ishikawa Y, Asuwa N, Inuzuka K, Ishihara M, Ito M, Masuda T, Akishima Y, Zhang L, Ito K, Ishii T. Detection of apoptosis in keloids and a comparative study on apoptosis between keloids, hypertrophic scars, normal healed flat scars, and dermatofibroma. Wound Repair Regen 2001;9(6):501-506. 18. Ishikawa Y, Akasaka Y, Ishii T, Itoh K, Masuda T, Zhang L, Kiguchi H. Sequential changes in localization of repair-related proteins (heat shock protein 70, ubiquitin and vascular endothelial growth factor) in the different stages of myocardial infarction. Histopathology 2000;37:546-554. 19. Ishikawa Y, Asuwa N, Ishii T, Ito K, Akasaka Y, Masuda T, Zhang L, Kiguchi H. Collagen alteration in vascular remodeling by hemodynamic factors. Virchows Arch 2000;437:138-148.

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