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个人简介

教育背景 1999-09--2004-07 中南大学,湘雅医学院,博士(硕博连读) 1994-09--1999-07 长治医学院,临床医学系,学士 工作经历 2019-03--至今 天津医科大学,基础医学院免疫系,教授 2010-01--2019-02 中山大学,中山医学院,教授 2007-06--2009-12 美国H Lee Moffitt肿瘤中心,博士后 2004-09--2007-05 美国匹茨堡大学, 遗传药理中心,博士后 荣誉奖励 (1)2010年度教育部“新世纪优秀人才”支持计划 (2)2014年度广东省“珠江学者”特聘教授 (3)2015年度美国免疫学年会“AAI Early Career Faculty Travel Grant”

研究领域

黏膜免疫调节机制及疾病意义

近期论文

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1.Cao Y#, Yang Q, Deng H, Tang J, Hu J, Liu H, Zhi M, Ye L, Zou B, Liu Y, Wei L, Gabrilovich DI, Wang H, Zhou J*. Transcriptional factor ATF3 protects against colitis by regulating follicular helper T cells in Peyer's patches. Proc Natl Acad Sci U S A. 2019 Mar; 116(13):6286-6291. (IF: 9.58) 2.Yu-Feng Liu#, Michela Perego, Qiang Xiao, Yumei He, Shu-Yu Fu, Juan He, Wangkai Liu, Xing Li, Yanlai Tang, Xiaoyu Li, Weiming Yuan, Wei Zhou, Fan Wu, Chuhong Jia, Qiliang Cui, George S. Worthen, Erik A. Jensen, Dmitry I. Gabrilovich*, Jie Zhou*. Ex-vivo generated myeloid-derived suppressor cells in therapy of inflammation in newborns. J CLIN INVEST. 2019 Sep; https://doi.org/10.1172/JCI128164 (in press) (IF:13.25) 3.Liu T#, Yang Q#, Cao YJ#, Yuan WM#, Lei AH, Zhou P, Zhou W, Liu YD, Shi MH, Yang Q, Tang JY, Wang HK, Zhang H, Yu Y, Zhou J*. Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E2. J Immunol. 2019 Aug;203(4):864-872. (IF: 4.72) 4.He YM#, Li X#, Perego M#, Nefedova Y, Kossenkov AV, Jensen EA, Kagan V, Liu YF, Fu SY, Ye QJ, Zhou YH, Wei L, Gabrilovich DI*, Zhou J*. Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation. Nat Med. 2018 Feb;24(2):224-231. (IF: 30.64) 5.Lei AH#, Xiao Q#, Liu GY, Shi K, Yang Q, Li X, Liu YF, Wang HK, Gabrilovich D, Zhou J*. ICAM-1 regulates development and function of ILC2. J Exp Med. 2018 Aug;215(8):2157-2174. (IF: 10.89) 6.Zhou J#, Nefedova Y, Lei A, Gabrilovich D*. Neutrophils and PMN-MDSC: Their biological role and interaction with stromal cells. Semin Immunol. 2018 Feb;35:19-28. (IF: 7.36) (Review) 7.Liu YF#, Zhang SY#, Chen YY, Shi K, Zou B, Liu J, Yang Q, Jiang H, Wei L, Li CZ, Zhao M, Gabrilovich DI, Zhang H*, Zhou J*. ICAM-1 Deficiency in the Bone Marrow Niche Impairs Quiescence and Repopulation of Hematopoietic Stem Cells. Stem Cell Reports. 2018 Jun 14. pii: S2213-6711(18)30234-0. (IF: 5.49) 8.Yang Q#, Li X, Chen H, Cao Y, Xiao Q, He Y, Wei J, Zhou J*. IRF7 regulates the development of granulocytic myeloid-derived suppressor cells through S100A9 transrepression in cancer. Oncogene. 2017 May 25;36(21):2969-2980. (IF: 6.63) 9.Liu YF#, Chen YY#, He YY#, Wang JY, Yang JP, Zhong SL, Jiang N, Zhou P, Jiang H*, Zhou J*. Expansion and activation of granulocytic, myeloid-derived suppressor cells in childhood precursor B cell acute lymphoblastic leukemia. J Leukoc Biol. 2017 Aug;102(2):449-458.(IF: 4.01) 10.Liu YF#, Wei JY, Shi MH, Jiang H, Zhou J*. Glucocorticoid Induces Hepatic Steatosis by Inhibiting Activating Transcription Factor 3 (ATF3)/S100A9 Protein Signaling in Granulocytic Myeloid-derived Suppressor Cells. J Biol Chem. 2016 Oct 7;291(41):21771-21785. (IF: 4.11) 11.Pan T#, Liu Y, Zhong L, Shi M, Duan X, Wu K, Yang Q, Liu C, Wei J, Ma X, Shi K, Zhang H, Zhou J*. Myeloid-derived suppressor cells are essential for maintaining feto maternal immunotolerance via STAT3 signaling in mice. J Leuko Biol. 2016 Sep;100(3):499-511. (IF: 4.01) 12.Yang Q#, Wei J, Zhong L, Shi M, Zhou P, Zuo S, Wu K, Zhu M, Huang X, Yu Y, Zhang H, Yin H, Zhou J*. Cross talk between histone deacetylase 4 and STAT6 in the transcriptional regulation of arginase 1 during mouse dendritic cell differentiation. Mol Cell Biol. 2015 Jan;35(1):63-75. (IF: 3.74) 13.Yang Q#, Shi M, Shen Y, Cao Y, Zuo S, Zuo C, Zhang H, Gabrilovich DI, Yu Y*, Zhou J*. COX-1-derived thromboxane A2 plays an essential role in early B-cell development via regulation of JAK/STAT5 signaling in mouse. Blood. 2014 Sep; 124(10):1610-21. (IF: 16.56) 14.Shi M#, Shi G#, Tang J, Kong D, Bao Y, Xiao B, Zuo C, Wang T, Wang Q, Shen Y, Wang H, Funk CD, Zhou J*, Yu Y*. Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyperresponsiveness in mice. J Allergy Clin Immunol. 2014 Nov; 134(5):1163-74. (IF: 14.11) 15.Qin A#, Cai W#, Pan T#, Wu K, Yang Q, Wang N, Liu Y, Yan D, Hu F, Guo P, Chen X, Chen L, Zhang H, Tang X*, Zhou J*. Expansion of monocytic myeloid-derived suppressor cells dampens T cell function in HIV-1-seropositive individuals. J Virol. 2013 Feb; 87(3):1477-90. (IF: 4.32) 16.Yan D#, Yang Q, Shi M, Zhong L, Wu C, Meng T, Yin H, Zhou J*. Polyunsaturated fatty acids promote the expression of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway. Eur J Immunol. 2013 Nov; 43(11):2943-55. (IF: 4.69) 17.Cheng P#, Zhou J#, Gabrilovich DI*. Regulation of dendritic cell differentiation and function by Notch and Wnt pathways. Immunol. Rev. 2010, 234:105-119. (IF: 11.29) (Review) 18.Zhou J#, Cheng P, Youn JI, Cotter MJ, Gabrilovich DI*. Notch and Wingless Signaling Cooperate in Regulation of Dendritic Cell Differentiation. Immunity 2009, 30(6):845-859. (IF: 21.52) 19.Zhou J#, Febbraio M, Wda T, Zhai Y, Kuruba R, He J, Lee JH, Khadem S, Ren S, Li S, Silverstein RL, Xie W*. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPAR gamma in promoting steatosis. Gastroenterology 2008,134:556-567. (IF: 19.23)

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