冯善宇 - 天津医科大学

个人简介

教育背景博士 2003.05-2008.03 加拿大滑铁卢大学，化学工程系（生物医学工程专业）硕士 2000.09-2002.10 加拿大滑铁卢大学，化学工程系（生物医学工程专业）学士 1993.09-1997.06 国立台湾大学，化学工程系工作经历 2018.04- 天津医科大学基础医学院免疫系教授 2012.01-2018-08 加拿大英属哥伦比亚大学医学院，BC省儿童医院研究院副研究员（Research Associate） 2008.07-2011.09 加拿大多伦多大学医学院，大学健康网络博士后荣誉奖励 2015年度儿童与家庭研究院（已更名为BC省儿童医院研究院）优秀青年研究人员代表 2013-2015 Bertram Hoffmeister 博士后研究基金，BC省儿童医院研究院 2008-2010 加拿大安大略省研究与创新部门博士后研究基金 2008-2010 加拿大玛嘉烈特公主医院 Michael V. 与 Wanda Plachta 夫妇研究基金 2005-2007 加拿大自然科学与工程研究理士会，加拿大博士研究生奖学金

研究领域

自身性炎症反应中的免疫信号转导与调控

近期论文

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J. Quancard#, T. Klein#, S.Y. Fung#, M. Renatus#, N. Aubin, L. Israël, J. J. Priatel, S. Kang, M.A. Blank, R.I. Viner, J. Blank, A. Schlapbach, P. Erbel, R. Hersperger, S.E. Turvey, J. Eder, F. Bornancin*, C.M. Overall*. An allosteric inhibitor rescues mutant MALT1 and lymphocyte function in an immunodeficient patient. Nature Chemical Biology 2019 15:304-313 (IF:12.154) T. Klein#, S.Y. Fung#, F. Renner#, M.A. Blank, A. Dufour, J.J. Priatel, M. Bolger-Munro, J.M. Scrull, S. Kang, P. Schweigler, S. Melkko, M.R. Gold, R.I. Viner, C.H. Régnier*, S.E. Turvey*, C.M. Overall*. The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-kB signaling. Nature Communications 2015 6:8777 doi: 10.1038/ncomms9777 (IF:11.878; citation:56) M.L. Mckinnon#, J. Rozmus#, S.Y. Fung#, A.F. Hirschfeld, K.L. Del Bel, L. Thomas, N. Marr, S.D. Martin, A.K. Marwaha, R. Tan, C. Senger, A. Tsang, J. Prendiville, A.K. Junker, M. Seear, K.R. Schultz, L.M. Sly, R.A. Holt, M.S. Patel, J.M. Friedman, S.E. Turvey*. Combined immunodeficiency associated with homozygous MALT1 mutation. Journal of Allergy and Clinical Immunology 2014 133:1458-1462 e7 (IF:14.110; citation:47) S.Y. Fung, V. Sofiyev, J. Schneiderman, A.F. Hirschfeld, R.E. Victor, K. Woods, J.S. Piotrowski, R. Deshpande, C. Sheena, S.C. Li, N.J. de Voogd, C.L. Myers, C. Boone, R.J. Andersen, S.E. Turvey*. Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis. ACS Chemical Biology 2014 9:247-257 (IF:4.374; citation:11) R. Bawa#, S.Y. Fung#, A. Shiozaki, H. Yang, G. Zheng, S. Keshavjee, M. Liu*. Self-assembling peptide based nanoparticles enhance cellular delivery of the hydrophobic anticancer drug ellipticine through a caveolin-dependent endocytotic mechanism. Nanomedicine: Nanotechnology Biology and Medicine 2012 8:647-654 (IF:5.570; citation:32) T. Oyaizu#, S.Y. Fung#, A. Shiozaki, Z. Guan, Q. Zhang, C.C. dos Santos, B. Han, M. Mura, S. Keshavjee, M. Liu*. Src tyrosine kinase inhibition prevents pulmonary ischemia-reperfusion induced acute lung injury. Intensive Care Medicine 2012 38:894-905 (IF:18.967; citation:30) S.Y. Fung, T. Oyaizu, H. Yang, Y. Yuan, B. Han, S. Keshavjee, M. Liu*. The potential of nanoscale combinations of self-assembling peptides and amino acids of the Src tyrosine kinase inhibitor in acute lung injury therapy. Biomaterials 2011 32:4000-4008 (IF:10.273; citation:18) S.Y. Fung#, H. Yang#, P. Sadatmousavi, Y. Sheng, T. Mamo, R. Nazarian, P. Chen*. Amino acid pairing for de novo design of self-assembling peptides and their drug delivery potentials. Advanced Functional Materials 2011 21:2456-2464 (IF:15.621; citation:28) S.Y. Fung, H. Yang, P.T. Bhola, P. Sadatmousavi, E. Muzar, M. Liu, P. Chen*. Self-assembling peptide as a potential carrier for hydrophobic anticancer drug ellipticine: complexation, release and in vitro delivery. Advanced Functional Materials 2009 19:74-83 (IF:15.621; citation:65)