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个人简介

教育背景 2005/9–2008/7 天津医科大学 免疫学 博士 1994/9–1997/7 天津医科大学 生物化学与分子生物学 硕士 1983/9–1987/7 南开大学 分析化学 学士 工作经历 2009/12-至今 天津医科大学 基础医学院免疫系 教授 2004/1-2009/11 天津医科大学 基础医学院免疫系 副教授 1999/3-2003/12 加拿大多伦多病童医院 细胞生物学系 访问学者 1993/12-1999/2 天津医科大学 分析中心 助理研究员 1987/7-1993/11 天津医科大学 分析中心 助教 荣誉奖励 天津市科技进步二等奖 第三名

研究领域

肥胖和糖尿病的发病及治疗相关的分子机制

近期论文

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1.Hu F,Li N, Li Z,Zhang C, Liu Q,Chen L, Bilan PJ,Niu W* Electrical pulse stimulation induces GLUT4 translocation in a Rac-Akt dependent manner in C2C12 myotubes, FEBS Lett, 2018.2.1, 592(4): 644-654 2.Deng B,Zhu X,Zhao Y,Zhang D, Pannu A,Chen L, Niu W* PKC and Rab13 mediate Ca2+ signal-regulated GLUT4 traffic, Biochem Biophys Res Commun.,2018.1.8, 495(2): 1956-1963 3.Zhao Y, Li N,Li Z, Zhang D,Chen L, Yao Z,Niu W* Conditioned medium from contracting skeletal muscle cells reverses insulin resistance and dysfunction of endothelial cells., Metabolism-Clinical and Experimental, 2017.1 2.25, 4.Li Z, Yue Y, Hu F, Zhang C, Ma X, Li N, Qiu L, Fu M, Chen L, Yao Z, Bilan PJ, Klip A, Niu W* Electrical pulse stimulation induces GLUT4 glucose transporter translocation in C2C12 myotubes that depends on Rab8A, Rab13 and Rab14 .Am. J. Physiol. Endocrinol. Metab. 2017. 5.Li Q, Zhu X, Ishikura S, Zhang D, Gao J, Sun Y, Contreras-Ferrat A, Foley KP, Lavandero S, Yao Z, Bilan PJ, Klip A,Niu W*. Ca2+signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells. Am. J. Physiol. Endocrinol. Metab. 2014;307(2):E209-24. 6.Li Z, Ni C, Yao Z, Chen L,Niu W*. Liraglutide enhances glucose transporter 4 translocation via regulation of AMP-activated protein kinase signaling pathways in mouse skeletal muscle cells. Metabolism-Clinical and Experimental. Metabolism-Clinical and Experimental. 2014;63(8):1022-30. 7.Yu J, Shi L, Wang H, Bilan PJ, Yao Z, Samaan MC, He Q, Klip A, Niu W*.Conditioned medium from hypoxia-treated adipocytes renders muscle cells insulin resistant. European Journal of Cell Biolog. 2011; 90: 1000-1015. 8.Wang G, Zhu Y, Li C, Tang Y, Jiang Z, Yang M, Ni C, Chen L*, Niu W*. The relationship between circulating irisin levels and tissues AGE accumulation in type 2 diabetes patients. Biosci Rep. 2017 Apr 13;37:1-7. 9.Li N, Zhao Y, Yue Y Chen L, Yao Z, Niu W*. Liraglutide ameliorates palmitate-induced endothelial dysfunction through activating AMPK and reversing leptin resistance. Biochem Biophys Res Commun. 2016;478(1):46-52. 10.Qin N, Chen Y, Jin M, Zhang C, Qiao W, Yue X, Duan H*, Niu W*. Anti-obesity and anti-diabetic effects of flavonoid derivative (Fla-CN) via microRNA in high fat diet induced obesity mice. Eur J Pharm Sci. 2015; 82:52-63. 11.Chen Y, Zhang C, Jin M, Qin N, Qiao W, Yue X, Duan H*, Niu W*. Flavonoid derivative exerts an antidiabetic effect via AMPK activation in diet-induced obesity mice. Nat Prod Res. 2015; 29:1-5. 12.Shi L, Qin N, Hu L, Liu L, Duan H*,Niu W*. Tiliroside-derivatives enhance GLUT4 translocation via AMPK in muscle cells. Diabetes Research and Clinical Practice. 2011; 92(2): e41-6. 13.Qin N, Li C, Jin M, Shi L, Duan H*, Niu W*. Synthesis and biological activity of novel tiliroside derivants. European Journal of Medicinal Chemistry. 2011; 46: 5189-5195. 14.Niu W*, Ishiki M, Bilan PJ, Yao Z. Glucose transporter 4 can insert in the membrane without exposing its catalytic site for photolabeling from the medium. Science in China Series-C: Life Sciences. 2007; 50(2):147-154. 15.Niu W*, Bilan PJ, Hayashi M, Da Y, Yao Z, Insulin sensitivity and inhibition by forskolin, dipyridamole and pentobarbital of glucose transport in three L6 muscle cell lines. Science in China Series-C: Life Sciences. 2007; 50(6):739-747. 16.Niu W, Bilan PJ, Yu J, Gao J, Boguslavsky S, Schertzer JD, Chu G, Yao Z. PKCe regulates contraction-stimulated GLUT4 traffic in skeletal muscle cells. Journal of Cellular Physiology. 2011; 226(1): 173-80. 17.Niu W, Bilan P J, Ishikura S, Schertzer J D, Contreras-Ferrat A, Fu Z, Liu J, Boguslavsky S, Foley K P, Liu Z, Li J, Chu G, Panakkezhum T, Lopaschuk G D, Lavandero S, Yao Z, Klip A. Contraction- related stimuli regulate GLUT4 traffic in C2C12-GLUT4myc skeletal muscle cells. Am. J. Physiol. Endocrinol. Metab. 2010; 298(5): E1058-71. 18.Niu W, Huang C, Nawaz Z, Levy M, Somwar R, Li D, Bilan PJ, Klip A. Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis. J. Biol. Chem. 2003;278 (20): 17953-17962. 19.Osorio-Fuentealba C, Contreras-Ferrat AE, Altamirano F, Espinosa A, Li Q, Niu W, Lavandero S, Klip A, Jaimovich E. Electrical Stimuli Release ATP to Increase Glucose Uptake and GLUT4 Translocation via PI3Kγ-Akt-AS160 in Skeletal Muscle Cells. Diabetes. 2013;62(5):1519-26. 20.JeBaily L, Wanono O, Niu W, Roessler J, Rudich A and Klip A. Ceramide- and oxidant-induced insulin resistance involves loss of insulin-dependent rac-activation and actin remodling in muscle cells. Diabetes. 2007; 56:394-403.

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