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个人简介

教育背景 1990.09–1995.06 华西医科大学 医学学士 2001.09–2004.06 天津医科大学. 医学硕士 2002.02–2004.06 天津外国语学院 英语专业本科 2005.09–2008.06 天津医科大学 医学博士 工作经历 2018.09–2018.12 美国加州大学洛杉矶分校,访问学者 2018.02–2018.04 美国哈佛医学院,访问学者 2014.07–2014.09 德国慕尼黑工业大学,访问学者 2012.10- 至今 天津医科大学,基础医学院,副教授 2011.12-2017.06 天津医科大学,博士后 2010.09-2011.09 瑞典于默奥大学,访问学者 2009.09-2010.05 美国休斯顿大学,博士后 2004.07-2012.09 天津医科大学,基础医学院,讲师 1995.07-2001.06 天津市和平区卫生防病站,医师 荣誉奖励 1. 2018年国家留学基金委青年骨干教师出国研修项目/高等教育教学出国研修项目奖学金 2. 2017年天津市人力资源与保障局优秀博士后国际化培养计划奖学金 3. 2017年天津市教委天津市高校中青年骨干创新人才计划 4. 2014年国家留学基金委及DAAD/DFG中德学者短期合作交流奖学金 5. 2010年国家留学基金委中瑞互换奖学金 6. 指导国家级别大学生创新创业项目2项:2017年、2018年 7. 指导学生参加全国大学生基础医学创新论坛,获得国家级三等奖,2016年 8. 指导学生参加“挑战杯”天津市大学生课外学术科技作品竞赛,一等奖,2011年

研究领域

病毒与肿瘤、肿瘤转移表观遗传调控

近期论文

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Liu Y, Zhang X, Yang B, Zhuang H, Guo H, Wei W, Li Y, Chen R, Li Y*, Zhang N*. Demethylation-induced overexpression of Shc3 drives c-Raf-independent activation of MEK/ERK in HCC. Cancer Res. 2018 May 1; 78(9): 2219 - 2232. Chen R, Liu Y, Zhuang H, Yang B, Hei K, Xiao M, Hou C, Gao H, Zhang X, Jia C, Li L, Li Y*, Zhang N*. Quantitative proteomics reveals that the long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation. Nucleic Acids Res. 2017; 45(17): 9947 - 9959. Zhuang H, Qiang Z, Shao X, Wang H, Dang Y, Wang Z, Wu F, Wei W*, Li Y*. Integration of metabolomics and expression of enolase-phosphatase 1 links to hepatocellular carcinoma progression. Theranostics. 2019 April 19; 9(12): 3639 - 3652. Zhuang H, Wu F, Wei W, Dang Y, Yang B, Ma X, Han F*, Li Y*. Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma. Cell Death & Disease 2019 Feb 25; 10(3): 192. Ma X, Dang Y, Shao X, Chen X, Wu F, Li Y*. Ubiquitination and long non-coding RNAs regulate actin cytoskeleton regulators in cancer progression. Int J Mol Sci. 2019 Jun 19;20(12). pii: E2997. Li Y#, Zhuang H, Zhang X, Li Y, Liu Y, Yi X, Qin G, Wei W, Chen R. Multi-omics integration reveals the landscape of pro-metastasis metabolism in hepatocellular carcinoma. Mol Cell Proteomics 2018; 17(4):607-618. Zhuang H, Li Q, Zhang X, Ma X, Wang Z, Liu Y, Yi X, Chen R, Han F, Zhang N*, Li Y*. Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells. Free Radical Biology & Medicine. 2018 Mar 7; 120: 1-12. Zhang X, Zhuang H, Han F, Shao X, Liu Y, Ma X, Wang Z, Qiang Z, Li Y*. SP1-regulated transcription of RasGRP1 promotes HCC proliferation. Liver Int. 2018;38(11):2006-2017. Wang F, Shan S, Huo Y, Xie Z, Fang Y, Qi Z, Chen F, Li Y*, Sun B*. MiR-155-5p inhibits PDK1 and promotes autophagy via the mTOR pathway in cervical cancer. Int J Biochem Cell Biol. 2018 Apr 5; 99: 91-99. Yang B, Liu Y, Zhao J, Hei K, Zhuang H, Li Q, Wei W, Chen R, Zhang N*, Li Y*. Ectopic overexpression of filamin C scaffolds MEK1/2 and ERK1/2 to promote the progression of human hepatocellular carcinoma. Cancer Lett. 2017; 388:167-176 Li Y#, Fan X, Li C, Zhi X, Peng L, Han H, Bei S. The relationships among hyperuricemiahypericemia, BMI and impaired renal function in type 2 diabetic patients. Endocrine Journal. 2018 Mar 28; 65(3): 281-290. Qiu Y, Zhao M, Sun L, Yang B, Hei K, Du X, Li Y*. Long non-coding RNA UCA1 overexpression as potential therapeutic target in ovarian cancer. Eur J Gynaecol Oncol. 2017; 38(2): 191-195. Feng Y, Ma J, Fan H, Liu M, Zhu Y, Li Y, Tang H. TNF-α-induced lncRNA LOC105374902 promotes the malignant behavior of cervical cancer cells by acting as a sponge of miR-1285-3p. Biochem Biophys Res Commun. 2019 May 21; 513(1): 56 - 63 Fu H, He Y, Qi L, Chen L, Luo Y, Chen L, Li Y, Zhang N, Guo H. cPLA2α activates PI3K/AKT and inhibits Smad2/3 during epithelial-mesenchymal transition of hepatocellular carcinoma cells. Cancer Lett. 2017; 403: 260-270. Wang F, Shan S, Li Y, Zhu E, Yin L, Sun B. miR-224-3p inhibits autophagy in cervical cancer cells by targeting FIP200. Sci Rep. 2016; 6:33229. Chen R, Xiao M, Gao H, Chen Y, Li Y, Liu Y, Zhang N. Identification of a Novel Mitochondrial Interacting Protein of C1QBP using Subcellular Fractionation Coupled with CoIP-MS. Anal Bioanal Chem. 2016; 408(6): 1557-1564 Zhuang H, Zhao M, Hei K, Yang B, Sun L, Du X, Li Y*. Aberrant expression of Pim-3 promotes proliferation and migration of ovarian cancer cells. Asian Pac J Cancer Prev. 2015; 16 (8); 3325-333. Zhao M, Qiu Y, Yang B, Sun L. Hei K, Du X, Li Y*. Long non-coding RNAs involved in gynecological cancer. Int J Gynecol Cancer. 2014; 24(7): 1140-1145. Höglund A, Strömvall K, Li Y, Forshell LP, Nilsson JA. Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition. Cell Cycle 2010; 10(20): 3598 - 3607 Forshell LP, Li Y, Forshell TZ, Rudelius M, Nilsson L, Keller U, Nilsson J. The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas. Oncotarget 2011; 2(6): 448-460.

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