张显志 - 天津医科大学

个人简介

教育背景 1989.9-1993.7 学士北京中医药大学中药系中药制药专业 1998.9-2004.6 博士芬兰坦佩雷大学医学院药理系 2004.6-2005.12 博士后芬兰坦佩雷大学医学院免疫药理研究室 2009.6-2010.6 博士后芬兰坦佩雷医学技术研究所工作经历 2010.10-至今副教授天津医科大学基础医学院 2007.1-2009.05　商务经理北京美利讯公司 2006.1-2006.12　副研究员中国科学院生物物理研究所 1998.9-2005.12　实验研究员芬兰坦佩雷大学医学院药理系 1993.7-1998.04　实验研究员军事医学科学院放射医学研究所

研究领域

细胞凋亡、寄生虫感染

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhu X ，Sun Y，Mu X，Guo P，Gao F，Zhang J，Zhu Y，Chen L，Zhang X，Ning Z，Bai Y，Ren J，Man M，Liu P ，Hu L ，Phospholipase Cepsilon deficiency delays the early stage of cutaneous wound healing and attenuates scar formation in mice.，Biochem Biophys Res Commun，2017，484（1）：144~151 2．Kankaanranta H ，Ilmarinen P，，Adcock I M，Lahti A，Barnes PJ，Zhang X，Giembycz M A，Lindsay M A，Moilanen E，Tumour Necrosis Factor-alpha Regulates Human Eosinophil Apoptosis via Ligation of TNF-Receptor 1 and Balance between NF-kappa B and AP-1，Plos One，2014，9（2） 3. Liu J ，Lu P，Hu L，Shen Y，Zhu Y，Ren J，Ji W，，Wu Z，Yang X，Zhang X，Yang J，Li L，Yang X ，Liu P ，CD8alpha DC is the major DC subset which mediates inhibition of allergic responses by Schistosoma infection.，Parasite Immunol，2014，36（12）：647~657 4. Dong L ，Zhang X，Fu X，，Gao X，Zhu M，Wang X，Yang Z，Jensen ON，Zhang X，Saarikettu J，Yao Z，Silvennoinen O ，Yang J ，PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1.，J Biol Chem，2011，286（5）：3451~3459 5. Kankaanranta H, Janka-Junttila M, Ilmarinen-Salo P, Ito K, Jalonen U, Ito M, Adcock IM, Moilanen E, Zhang X. Histone deacetylase inhibitors induce apoptosis in human eosinophils and neutrophils. J Inflamm (Lond). 2010; 4:7-9. 6. Perttunen H, Moilanen E, Zhang X, Barnes PJ, Kankaanranta H. Beta2-agonists potentiate corticosteroid-induced neutrophil survival. COPD. 2008;5:163-169. 7. Kankaanranta H, Zhang X, Tumelius R, Ruotsalainen M, Haikala H, Nissinen E, Moilanen E. Antieosinophilic activity of simendans. J Pharmacol Exp Ther. 2007 323:31-8. 8. Hasala H, Zhang X, Saarelainen S, Moilanen E, Kankaanranta H. c-Jun N-terminal kinase mediates constitutive human eosinophil apoptosis. Pulm Pharmacol Ther. 2007;20:580 9. Janka-Junttila M, Moilanen E, Hasala H, Zhang X, Adcock I, Kankaanranta H. The glucocorticoid RU24858 does not distinguish between transrepression and transactivation in primary human eosinophils. J Inflamm (Lond). 2006 3:10. 10. Kankaanranta H, Ilmarinen P, Zhang X, Nissinen E, Moilanen E. Antieosinophilic activity of orazipone. Mol Pharmacol. 2006 69:1861-1870. 11. Hasela H, Malm-Erjefalt M, Erjefalt J, Giembycz MA, Zhang X, Moilanen E, Kankaanranta H. Ketotifen induces primary necrosis of human eosinophils. J Ocul Pharmacol Ther. 2005 21:318-327 12. Kankaanranta H, Moilanen E, Zhang X. Pharmacological regulation of human eosinophil apoptosis. Curr Drug Targets Inflamm Allergy. 2005 4:433-45 13. Zhang X, Moilanen E, Lahti A, Hamalainen M, Giembycz MA, Barnes PJ, Lindsay MA, Kankaanranta H. Regulation of eosinophil apoptosis by nitric oxide: Role of c-Jun-N-terminal kinase and signal transducer and activator of transcription 5. J Allergy Clin Immunol. 2003 112:93-101. 14. Zhang X, Moilanen E, Adcock IM, Lindsay MA, Kankaanranta H. Divergent effect of mometasone on human eosinophil and neutrophil apoptosis. Life Sci. 2002 71:1523-1534. 15. Kankaanranta H, Giembycz MA, Barnes PJ, Haddad el-B, Saarelainen S, Zhang X, Moilanen E, Lindsay MA. Hydrogen peroxide reverses IL-5 afforded eosinophil survival and promotes constitutive human eosinophil apoptosis. Int Arch Allergy Immunol. 2002 127:73-78. 16. Zhang X, Moilanen E, Kankaanranta H. Beclomethasone, budesonide and fluticasone propionate inhibit human neutrophil apoptosis. Eur J Pharmacol. 2001 431:365-371 17. Zhang X, Moilanen E, Kankaanranta H. Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone. Eur J Pharmacol. 2000 406: 325 –332 18. Kankaanranta H, Lindsay MA, Giembycz MA, Zhang X, Moilanen E, Barnes PJ. Delayed eosinophil apoptosis in asthma. J Allergy Clin Immunol. 2000 106:77-83.