个人简介
天津市“131”创新型人才第三层次人选
主要研究方向和领域
1. 运动防治代谢相关疾病(肥胖,二型糖尿病)的分子机制研究
2. 中枢神经损伤修复的机制研究
主要教育经历
2011.09-2014.06:四川大学,人体解剖和组织胚学,医学博士
2008.09-2011.06:天津体育学院,运动人体科学,理学硕士
2004.09-2008.06:河北体育学院,运动人体科学,教育学学士
主要学术兼职
1. 第五届脑损伤与脑卒中康复专委会 委员 2020-2025
2. 英国运动医学杂志中文版(British Journal of Sports Medicine, BJSM),青年编委,2017.03-至今
3. 《临床医学前沿》杂志 编委
4. 中国生理学会,会员 2018.07-2022.07
主持或参加科研项目及人才计划项目情况(按时间倒序排序)
1. 中国博士后科学第66批面上项目(二等),2019M661042,Sestrins/AMPK在有氧运动改善肌减症作用机制的研究,2019.11-2021.10,5万元,在研,主持
2. 国家自然科学基金青年项目,81501071,神经干细胞和嗅鞘细胞联合移植促进创伤性脑外伤大鼠神经功能修复的分子机制研究,2016/01-2018/12,17.5 万元,结题,主持
3. 国家自然科学基金面上项目,31871206,Sestrin2/3 在有氧运动改善骨骼肌胰岛素抵抗过程中作用机制研究,2019.1-2022.12,60万元,在研,第3参加人
4. 国家自然科学基金面上项目,81771624,低氧诱导bFGF表达的神经干细胞对新生小鼠脑白质损伤的作用及机制研究,2018/01-2021/12,55万元,在研,第2参加人
5. 国家自然科学基金面上项目,81772405,机械加载通过调控骨重建和内质网应激治疗骨关节炎的机制研究,2018/01-2021/12,55万元,在研,第5参加人
6. 国家自然科学基金面上项目,31571220,Sestrins介导骨骼肌细胞自噬在有氧运动改善胰岛素抵抗中的作用机制,2016/01-2019/12,64万元,在研,第3参加人
7. 国家自然科学基金面上项目,81572100,Salubrinal通过调节内质网应激治疗骨质疏松的机制研究,2016/01-2019/12,57 万元,在研,第5参加人
8. 国家自然科学基金面上项目,81471268,针刺促进大鼠损伤脊髓皮质远程调控中 SNAP25的作用及 7.0 MR 分子影像研究,2015/01-2018/12,70 万元,结题,第3参加人
9. 国家自然科学基金青年项目,31100856,有氧运动对骨骼肌细胞 HDAC 的影响及其在改善胰岛素抵抗过程中的机制研究,2012/01-2014/12,22 万元,结题,第5参加人
参与书著(按时间倒序排序)
1. 生物信息学理论与技术(第一版), 2015年3月出版, 科学出版社, 编者
2. 干细胞理论和技术(第三版), 2013年6月1日出版, 科学出版社, 副主编
3. 神经细胞培养理论和技术(第三版), 2013年6月1日出版, 科学出版社, 副主编
近期论文
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Tianyi Wang, Wenqing Hu, Yanmei Niu, Sujuan Liu*, Li Fu*. Exercise improves lipid metabolic disorder induced by high-fat diet in a SESN2/JNK-independent manner. Appl Physiol Nutr Metab. 2021 May 26. doi: 10.1139/apnm-2021-0241.
Sujuan Liu, Chunxia Yu, Lingjian Xie, Yanmei Niu, Li Fu. Aerobic exercise improves mitochondrial function in sarcopenia mice through Sestrin2 in an AMPKα2-dependent manner. J Gerontol Ser A-Biol Sci Med Sci. 2021, 76 (7):1161-1168.
Haili Tian#, Sujuan Liu#, Jun Ren, Jason Kai Wei Lee, Ru Wang, Peijie Chen. Role of Histone Deacetylases in Skeletal Muscle Physiology and Systemic Energy Homeostasis: Implications for Metabolic Diseases and Therapy. Front Physiol. 2020, 11: 949.
Sujuan Liu, Yanmei Niu, Li Fu. Metabolic Adaptations to Exercise Training. Journal of Science in Sport and Exercise. 2020, 2:1-6.
Song Huang, Sujuan Liu, Yanmei Niu*, Li Fu. scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin. J Appl Physiol (1985). 2020, 128(2):276-285.
Sujuan Liu, Juan Mao, Tinghua Wang, Xuemei Fu. Downregulation of Aquaporin-4 Protects Brain Against Hypoxia Ischemia via Anti-inflammatory Mechanism. Mol Neurobiol. 2017, 54(8):6426-6435.
Sujuan Liu, Shengyun Zhu, Yu Zou, Tinghua Wang, Xuemei Fu. Knockdown of IL-1β improves hypoxia-ischemia brain associated with IL-6 up-regulation in cell and animal models. Mol Neurobiol. 2015, 51(2):743-52.
Sujuan Liu, Yu Zou, Longyun LV, Na Lin, Tingyong Wang, Xue Zhou, Qingjie Xia, Tinghua Wang. Co-grafting of neural stem cells with olfactory en sheathing cells promotes neuronal restoration in traumatic brain injury with an anti-inflammatory mechanism. J Neuroinflammation. 2014, 11(1):66.
Sujuan Liu, Susu Zheng, Qiqin Dan, Jia Liu, Tinghua Wang. Effects of Governor Vessel electroacupuncture on the systematic expressions of NTFs in spinal cord transected rats. Neuropeptides. 2014, 21; pii: S0143-4179(14)00034-1.
Chunxia Yu, Sujuan Liu, Liqin Chen, Jun Shen, Yanmei Niu, Tianyi Wang, Wanqi Zhang, Li Fu. Effect of Exercise and Butyrate on Gut Microbiota and Lipid Metabolism in Mice. J Endocrinol. 2019, 243(2):125-135.
Tianyi Wang, Yanmei Niu, Sujuan Liu, Xiaolei Liu, Li Fu. Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins. Biochim Biophys Acta Mol Basis Dis. 2018, 1864(10):3368-3377.
Yanmei Niu, Tianyi Wang, Sujuan Liu, Hairui Yuan, Huige Li, Li Fu. Exercise-induced GLUT4 transcription via inactivation of HDAC4/5 in mouse skeletal muscle in an AMPKα2-dependent manner. Biochim Biophys Acta Mol Basis Dis. 2017, 1863(9):2372-2381.
Huige Li, Sujuan Liu, Hairui Yuan,Yanmei Niu, Li Fu. Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes. Exp Cell Res. 2017, 354(1):18-24.
Xuemei Fu, Sujuan Liu, Qiqin Dan, Yanping Wang, Na Lin, Longyun LV, Yu Zou, Su Liu, Xue Zhou, Tinghua Wang. Combined Bone Mesenchymal Stem Cells and Olfactory En sheathing Cells Transplantation Promote Neural Repair Associated with CNTF Expression in Traumatic Brain Injured Rats. Cell Transplant. 2015, 24(8):1533-44.
Lushuang Xie, Yu Lai, Fang Lei, Sujuan Liu, Ran Liu, Tinghua Wang. Exploring the association between interleukin-1β and its interacting proteins in Alzheimer's disease. Mol Med Rep. 2015, 11(5):3219-28.
Ran Liu, Wei Zhao, Qi Zhao, Sujuan Liu, Jia Liu, Mu He, Yang Xu, Wei Wang, Wei Liu, Bao-Jiang Qian, Cui-Ying Li, Ting-Hua Wang. Endoplasmic Reticulum Protein 29 Protects Cortical Neurons From Apoptosis and Promoting Corticospinal Tract Regeneration to Improve Neural Behavior via Caspase and Erk Signal in Rats with Spinal Cord Transection. Mol Neurobiol. 2014, 50(3):1035-48.
Wei Wang, Fang Wang, Jia Liu, Wei Zhao, Qi Zhao, Mu He, Baojiang Qian, Yang Xu, Ran Liu, Sujuan Liu, Wei Liu, Jin Liu, Xinfu Zhou, Tinghua Wang. SNAP25 ameliorates sensory deficit in rats with spinal cord transection. Mol Neurobiol. 2014, 50(2):290-304.
Fen Liu, Yu Zou, Sujuan Liu, Jia Liu, Tinghua Wang. Electro-acupuncture treatment improves neurological function associated with downregulation of PDGF and inhibition of astrogliosis in rats with spinal cord transection. J Mol Neurosci. 2013, 51(2): 629-35.
Luo Y, Zou Y, Yang L, Liu J, Sujuan Liu, Liu J, Zhou X, Zhang W, Wang T. Transplantation of NSCs with OECs alleviates neuropathic pain associated with NGF downregulation in rats following spinal cord injury. Neurosci Lett. 2013, 549:103-8.
Baoli He, Yingchun Ba, Xuyang Wang, Sujuan Liu, Guodong Liu, Ou Shan, Yinli Gu, Xinghua Pan, Tinghua Wang. BDNF expression with functional improvement in transected spinal cord treated with neural stem cells in adult rats. Neuropeptides. 2013, 47(1):1-7.
Gu YL, Yin LW, Zhang Z, Liu J, Sujuan Liu, Zhang LF, Wang TH. Neurotrophin expressions in neural stem cells grafted acutely to transected spinal cord of adult rats linked to functional improvement. Cell Mol Neurobiol. 2012, 32(7):1089-97.