个人简介
教育背景
1989-1992年:北京大学医学部(北京医科大学)研究生
工作经历
2013.6-至今:天津医科大学人体解剖与组织胚胎学系主任、教授、博士生导师
2017.6-至今:天津市代谢性骨病实验室—国际华人骨研学会转化医学研究中心 主任
2017.5-至今:北京协和医学院基础学院及中国医学科学院放射所 讲座教授
2006-2013年:美国印第安纳大学生物医学工程学系、解剖与细胞生物系研究教授
2005-2006年:美国印第安纳大学医学院生物医学工程学系博士后
2001-2005年:美国印第安纳大学医学院心血管研究中心、解剖与细胞生物博士后
1998-2001年:北京协和医学院基础学院及中国医学科学院基础医学研究所 副教授、硕士研究生导师
1992-1998年:北京协和医学院基础学院及中国医学科学院基础医学研究所讲师
近期论文
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Yang S, Liu H, Zhu L, Li X, Liu D, Song X, Yokota H, Zhang P*. Ankle loading ameliorates bone loss from breast cancer-associated bone metastasis. FASEB J 2019 [Epub ahead of print].
Li X, Liu D, Li J, Yang S, Xu J, Yokota H, Zhang P*. Wnt3a involved in the mechanical loading on improvement of bone remodeling and angiogenesis in a postmenopausal osteoporosis mouse model. FASEB J 2019; 33:8913-8924.
Zheng W, Li X, Liu D, Li J, Yang S, Gao Z, Wang Z, Yokota H, Zhang P*. Mechanical loading mitigates osteoarthritis symptoms by regulating endoplasmic reticulum stress and autophagy. FASEB J 2019; 33:4077-4088.
Lin XS, Wang HY, Zhang Z, Liu HJ, Qu Z, Wu KL, Xiao QH, Zhu JZ, Zhang P. Effects of acupoint application therapy with TianGui powder on osteoporosis in ovariectomized rats through TGF-β1 and Smad2/3 signaling pathway. Orthop Surg 2019; 11(1):143-150.
Tan N, Li X, Zhai L, Liu D, Yokota H, Zhang P*. Effects of knee loading on obesity‐related nonalcoholic fatty liver disease in an ovariectomized mouse model with high fat diet. Hepatol Res 2018; 48:839-849.
Liu J, Tan X, Zhao W, Liu J, Xing X, Fan G, Zhang P, Zhang Z, Zhong Y, Kong D. In vitro and In vivo antimetastatic effects of ZSTK474 on prostate cancer DU145 cells. Curr Cancer Drug Targets 2019;19(4):321-329.
Zhang Z, Liu J, Wang Y, Tan X, Zhao W, Xing X, Qiu Y, Wang R, Jin M, Fan G, Zhang P, Zhong Y, Kong D. Phosphatidylinositol 3-kinase β and δ isoforms play key roles in metastasis of prostate cancer DU145 cells. FASEB J 2018; 32:5967-5975.
Liu D, Zhang Y, Li X, Li J, Yang S, Xing X, Fan G, Yokota H, Zhang P*. eIF2α signaling regulates ischemic osteonecrosis through endoplasmic reticulum stress. Sci Rep 2017; 7:5062.
Li J, Yang S, Li X, Liu D, Wang Z, Guo J, Tan N, Gao Z, Zhao X, Zhang J, Gou F, Yokota H, Zhang P*. Role of endoplasmic reticulum stress in disuse osteoporosis. Bone 2017; 97:2-14.
Li X, Yang J, Liu D, Li J, Niu K, Feng S, Yokota H, Zhang P*. Knee loading inhibits osteoclast lineage in a mouse model of osteoarthritis. Sci Rep 2016; 6:24668.
Liu D, Li X, Li J, Yang J, Yokota H, Zhang P*. Knee loading protects against osteonecrosis of the femoral head by enhancing vessel remodeling and bone healing. Bone 2015; 81:620-631.
Li X, Yang H, Li D, Zhang P, Ma Q, Zhai L. Muscular structure at the male bladder outlet examined with successive celloidin-embedded slices. Urology 2015; 85:629-635.
Yokota H, Hamamura K, Chen A, Dodge TR, Tanjung N, Abedinpoor A, Zhang P*. Effects of salubrinal on development of osteoclasts and osteoblasts from bone marrow-derived cells. BMC Musculoskel Disord 2013; 14:197.
Hamamura K, Zhang P, Zhao L, Shim JW, Chen A, Dodge TR, Wan Q, Shih H, Na S, Lin CC, Sun HB, Yokota H. Knee loading reduces MMP13 activity in the mouse cartilage. BMC Musculoskel Disord 2013; 14:312:1-11.
Rhodes SD, Wu X, He Y, Chen S, Yang H, Staser KW, Wang J, Zhang P, Jiang C, Yokota H, Dong R, Peng X, Yang X, Murthy S, Azhar M, Mohammad KS, Xu M, Guise TA, Yang FC. Hyperactive transforming growth factor-β1 signaling potentiates skeletal defects in a neurofibromatosis type 1 mouse model. J Bone Miner Res 2013; 28:2476-2489.
Chen A, Zhang P, Yokota H. Evaluating treatment of osteoporosis using particle swarm on a bone remodeling mathematical model. IET Systems Biol 2013; 7:231-242.
Zhang P, Hamamura K, Jiang C, Zhao L, Yokota H. Salubrinal promotes wound healing in rat femurs. J Bone Miner Metab 2012; 30:568-579.
Zhang P, Yokota H. Elbow loading promotes longitudinal bone growth of the ulna and the humerus. J Bone Miner Metab 2012; 30:31-39.
Zhang P, Jiang C, Yokota H. Lengthening of hind limbs with local administration of insulin-like growth factor 2. J Chin Med Assoc 2012; 75:494-500.
Zhang P, Yokota H. Knee loading stimulates healing of mouse bone wounds in a femoral neck. Bone 2011; 49:867-872.