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个人简介

教育背景 2003/9 - 2007/7,天津医科大学,免疫学,博士 1999/9 - 2002/7,天津医科大学,口腔修复学,硕士 1990/9 - 1995/7,天津医科大学,口腔医学,学士 工作经历 2018/04 – 至今,基础医学院党委书记,副院长 2011/04 - 至今,基础医学研究中心,基础医学院免疫学系,副教授 2016/03 – 2018/04,继续教育学院/广东路校区管理委员会,院长,主任委员 2005/03 - 2016/03,研究生院/研究生工作部,副书记、副部长;书记,部长(2008–2009,美国佐治亚医学院博士后;2014.08,英国利兹大学高级访问学者;) 1995/07 - 2005/03, 基础医学院七年制办公室,助教,讲师(2003.11-2004.02中科院上海药物研究所国家新药筛选中心科研合作)

研究领域

免疫炎症与自身免疫性疾病,肿瘤免疫

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

(1)Xue Z, Xi Q, Liu H, Guo X, Zhang J, Zhang Z, Li Y, Yang G, Zhou D, Yang H, Zhang Q, Gu C, Yang J, Da Y*, Yao Z, Duo S, Zhang R. miR-21 promotes NLRP3 inflammasome activation to mediate pyroptosis and endotoxic shock. Cell Death & disease.2019.06. doi: 10.1038/s41419-019-1713-z (2)Ren Y, Li Y, Lv J, Guo X, Zhang J, Zhou D, Zhang Z, Xue Z, Yang G, Xi Q, Liu H, Liu Z, Zhang L, Zhang Q, Yao Z, Zhang R, Da Y*. Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathwy in C2C12 myoblasts. Journal of Cellular Biochemistry . 2019.05 doi: 10.1002/jcb.28839.(3)Xu S, Liu R, Da Y*.Comparison of tumor related signaling pathways with known compounds to determine potential agents for lung adenocarcinoma. Thorac Cancer. 2018 Aug;9(8):974-988. (4)Cheng X, Wang H, Yang J, Cheng Y, Wang D, Yang F, Li Y, Zhou D, Wang Y, Xue Z, Zhang L, Zhang Q, Yang L, Zhang R, Da Y*. Arctigenin protects against liver injury from acute hepatitis by suppressing immune cells in mice. Biomed Pharmacother. 2018 Jun;102:464-471. (5)Xu S, Yang F, Liu R, Li X, Fan H, Liu J, Wei S, Chen G, Chen J, Da Y*.Serum microRNA-139-5p is downregulated in lung cancer patients with lytic bone metastasis. Oncol Rep. 2018 May;39(5):2376-2384. (6)Zhang Z, Xue Z, Liu Y, Liu H, Guo X, Li Y, Yang H, Zhang L, Da Y*, Yao Z, Zhang R*. MicroRNA-181c promotes Th17 cell differentiation and mediates experimental autoimmune encephalomyelitis. Brain Behav Immun. 2018 May;70:305-314. (7)Peng M, Zhang Q, Cheng Y, Fu S, Yang H, Guo X, Zhang J, Wang L, Zhang L, Xue Z, Li Y, Da Y*, Yao Z, Qiao L*, Zhang R*.Apolipoprotein A-I mimetic peptide 4F suppresses tumor-associated macrophages and pancreatic cancer progression. Oncotarget. 2017 Sep 22;8(59):99693-99706. (8)Yinghui Ren#, Yan Li#, Jun Yan#, Mingkun Ma,Dongmei Zhou, Zhenyi Xue, Zimu Zhang, Hongkun Liu, Huipeng Yang, Long Jia, Lijuan Zhang, Qi Zhang, Shuqin Mu,Rongxin Zhang*, and Yurong Da*. Adiponectin modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis. Sci Rep. 2017; 7: 3209. (9)Zhang K#, Ge Z#,Xue Z#, Huang W, Mei M, Zhang Q, Li Y, Li W, Zhang Z, Zhang Z, Zhang L, Wang H, Cai J, Yao Z, Zhang R*, Da Y*. Chrysin suppresses human CD14(+) monocyte-derived dendritic cells and ameliorates experimental autoimmune encephalomyelitis, J Neuroimmunol, 2015, 288:13-20 (10)Zhang kai#, Zhenzhen Ge#, Yurong Da#, Dong Wang, Ying Liu, Zhenyi Xue, Yan Li, Wen Li, Lijuan Zhang, Huafeng Wang, Huan Zhang, Meiyu Peng, Junwei Hao, Zhi Yao*, Rongxin Zhang*, Plumbagin suppresses dendritic cell functions and alleviates experimental autoimmune encephalomyelitis. Journal of Neuroimmunology 2014, 273(1-2): 42 –52 (11)Ge Zhenzhen#, Da Yurong#, Xue Zhenyi, Zhang Kai, Zhuang Hao, Peng Meiyu, Li Yan, Li Wen, Simard Alain, Hao Junwei, Yao, Zhi*, Zhang, Rongxin*, Vorinostat, a histone deacetylase inhibitor, suppresses dendritic cell function and ameliorates experimental autoimmune encephalomyelitis, Experimental Neurology, 2013, 241:56-66. (12)Li Y, Zhou D, Ren Y, Zhang Z, Guo X, Ma M, Xue Z, Lv J, Liu H, Xi Q, Jia L,Zhang L, Liu Y, Zhang Q, Yan J, Da Y, Gao F, Yue J, Yao Z, Zhang R. Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1.Autophagy. 2019 Mar;15(3):478-492. (13)Xue Z, Zhang Z, Liu H, Li W, Guo X, Zhang Z, Liu Y, Jia L, Li Y, Ren Y, Yang H, Zhang L, Zhang Q, Da Y, Hao J, Yao Z*, Zhang R*.lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation. Cell Death Differ. 2018 Apr 17. (14)Jia L, Xi Q, Wang H, Zhang Z, Liu H, Cheng Y, Guo X, Zhang J, Zhang Q, Zhang L, Xue Z, Li Y, Da Y, Zhao P, Zhang R. miR-142-5p regulates tumor cell PD-L1 expression and enhances anti-tumor immunity. Biochem Biophys Res Commun. 2017 Jun 24;488(2):425-431. (15)Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A. 2016 Nov15;113(46):13015-13020. (16)Zhang K, Guo Y, Ge Z, Zhang Z, Da Y, Li W, Zhang Z, Xue Z, Li Y, Ren Y, Jia L,Chan KH, Yang F, Yan J, Yao Z, Xu A, Zhang R. Adiponectin Suppresses T Helper 17 Cell Differentiation and Limits Autoimmune CNS Inflammation via the SIRT1/PPARγ/RORγt Pathway. Mol Neurobiol. 2017 Sep;54(7):4908-4920. (17)Li W, Zhang Z, Zhang K, Xue Z, Li Y, Zhang Z, Zhang L, Gu C, Zhang Q, Hao J,Da Y, Yao Z, Kong Y, Zhang R. Arctigenin Suppress Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis Through AMPK and PPAR-γ/ROR-γt Signaling. Mol Neurobiol. 2016 Oct;53(8):5356-66. (18)Peng M, Huang B, Zhang Q, Fu S, Wang D, Cheng X, Wu X, Xue Z, Zhang L, Zhang D, Da Y, Dai Y, Yang Q, Yao Z, Qiao L, Zhang R. Embelin inhibits pancreatic cancer progression by directly inducing cancer cell apoptosis and indirectly restricting IL-6 associated inflammatory and immune suppressive cells. Cancer Lett. 2014 Nov 28;354(2):407-16. (19)Xue Z, Li W, Wang H, Huang B, Ge Z, Gu C, Liu Y, Zhang K, Yang J, Han R, Peng M, Li Y, Zhang D, Da Y, Yao Z, Zhang R. ZSTK474, a novel PI3K inhibitor,modulates human CD14+ monocyte-derived dendritic cell functions and suppresses experimental autoimmune encephalomyelitis. J Mol Med (Berl). 2014 Oct;92(10):1057-68. (20)Peng M, Xu S, Zhang Y, Zhang L, Huang B, Fu S, Xue Z, Da Y, Dai Y, Qiao L,Dong A, Zhang R, Meng W. Thermosensitive injectable hydrogel enhances the antitumor effect of embelin in mouse hepatocellular carcinoma. J Pharm Sci. 2014 Mar;103(3):965-73.

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