李韶勇 - 天津医科大学

个人简介

教育背景 2005 中国科学院化学研究所，有机化学，博士 2002 天津师范大学，物理化学，硕士 1995 井冈山大学，应用化学工作经历 2005—至今天津医科大学，讲师，副教授 2010 美国密歇根科技大学，博士后 2009 美国密西西比州立大学，博士后

研究领域

1. 桥连手性杯[4]芳烃作为有机手性催化剂在手性药物合成中的应用有机手性催化剂一般是低分子量的手性有机分子，不包含过渡金属或其它金属，具有稳定、价廉和易得等优点。桥连手性杯[4]芳烃（bridging chiral calix[4]arene）是杯芳烃骨架上不对称排列的非手性基团使其对称面或对称中心缺失而获得手性的一类手性杯芳烃，具备了成为一类优秀有机手性催化剂的潜质，并在手性药物的合成中具有广阔的应用前景。 2. 抗类风湿性关节炎药物的研究类风湿性关节炎(rheumatoid arthritis, RA)是一种以侵犯关节滑膜为主要特征的慢性、炎症性的自身免疫性疾病，现有临床上使用的药物，有50%以上来源于天然产物及其衍生物。从确切临床疗效的中药和天然药物中发现天然活性化合物，仍然是发现新药、新靶点和新作用机制的重要手段，因而从天然药物中寻找和发现抗类风湿先导药物，并研究先导化合物的衍生合成和分子药理作用机制，目前已经成为了开发抗RA药物的理想途径。

近期论文

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D. Hua, W. Luo, J. Duan, D. Jin, X. Zhou, C. Sun, Q.Wang, C. Shi, Z. Jiang, R.Wang, C. Rao, S. Yu*, S. Li*, S. Tang*. Screening and identification of potent α-glycosidase inhibitors from Gardenia jasminoides Ellis. South African Journal of Botany, 2018, 119, 377-382. Wen-Shan Liu, Di He, Hao Ma, Xiu-Fang Weng, Shan-Shan Ren, Xiong Liu, Sheng-An Tang, Shi-Kun Ma, Jun-Min Liu, and Shao-Yong Li*. Bridging chiral de-tert-butylcalix[4]arenes: diastereomeric crystallization-based optical resolution and determination of absolute configuration. ChemistrySelect, 2018, 3, 10153-10156. Jun-Fang Wang, Li-Yuan Huang, Jian-Hua Bu, Shao-Yong Li, Su Qin, Yao-Wei Xu, Jun-Min Liu* and Cheng-Yong Su. A fluorescent calixarene-based dimeric capsule constructed via a MII–terpyridine interaction: cage structure, inclusion properties and drug release. RSC Advances, 2018, 8, 22530-22535. Weixiang Zhai, Yalan Feng, Huiqiang Liu, Antal Rockenbauer*, Deni Mance, Shaoyong Li, Yuguang Song*, Marc Baldus and Yangping Liu. Diastereoisomers of L-proline-linked tritylnitroxide biradicals: synthesis and effect of chiral configurations on exchange interactions. Chemical Science, 2018, 9, 4381-4391. Chuan Zhao, Jiao-Jiao Xu, Jia Wang, Shao-Yong Li, Wei Qiao, Sheng-An Tang*. Five new cembrane diterpenoids from the South China Sea soft coral Sinularia flexibilis. Phytochemistry Letters, 2018, 25, 180–183. Ming-Liang Chang, Yong He, Jing Zhou* and Shao-Yong Li*. Synthesis of N,O-type inherently chiral calix[4]arenes substituted on the lower rim and their organocatalysis properties. Journal of the Brazilian Chemical Society, 2017, 28, 1363-1370. Ming-Liang Chang, Yong He, Chuan Zhao, Lan-Fang Hao and Shao-Yong Li*. Four types of novel potential malate synthase inhibitors from virtual screening. Current Enzyme Inhibition, 2017, 13, 176-183. Wen-Qiang Xu, Wen-Shan Liu, Jiu-Xing Yan, Shi-Kun Ma, Jing Guo, Jun-Min Liu*, Run-Ling Wang*, and Shao-Yong Li*. An approach to optically pure bridging chiral p-tert-butylcalix[4]arenes through a homologous anionic ortho-Fries rearrangement. Journal of Organic Chemistry, 2016, 81, 10683−10687. Xinghua Liu, Chunhui Gao, Junheng Gu, Yunfang Jiang, Xinlin Yang, Shaoyong Li, Wei Gao, Tong An, Hongquan Duan, Jingwei Fu, Yinsong Wang*, and Xiaoying Yang*. Hyaluronic acid stabilized iodine-containing nanoparticles with Au nanoshell coating for X‑ray CT imaging and photothermal therapy of tumors. ACS Applied. Materials & Interfaces, 2016, 8, 27622−27631. Xu-Dong Lin, Biao Peng, Shao-Yong Li, Jia Shao, Qing-Zhong Li, Cheng-Zhi Xie* and Jing-Yuan Xu*. Novel Zn(II)-thiazolone-based solid fluorescent chemosensors: naked-eye detection for acid/base and toluene. RSC Advances, 2016, 6, 52310–52317. Feng-Jing An, Wen-Qiang Xu, Shuang Zheng, Shi-Kun Ma, Shao-Yong Li*, Run-Ling Wang* and Jun-Min Liu*. Bridging chiral calix[4]arenes: description, optical resolution, and absolute configuration determination. European Journal of Organic Chemistry, 2016, 1012–1016. Li-Lin Tan, Jun-Min Liu*, Shao-Yong Li, Li-Min Xiao, Dai-Bin Kuang and Cheng-Yong Su*. Dye-sensitized solar cells with improved performance using cone-calix[4]arene based dyes. ChemSusChem, 2015, 8(2), 280-287. Shuang Zheng, Ming-Liang Chang, Jing Zhou, Jing-Wei Fu, Qing-Wei Zhang, Shao-Yong Li*, Wei Qiao*, and Jun-Min Liu*. Qualitative analysis of the helical electronic energy of inherently chiral calix[4]arenes: an approach to effectively assign their absolute configuration. International Journal of Molecular Sciences, 2014, 15, 9844-9858. Yao-Wei Xu, Li-Lin Tan, Jun-Min Liu*, Li-Min Xiao, Shao-Yong Li* and Cheng-Yong Su*. Fluorescent calix[4]arene chemosensor for acidic and basic amino acids in pure aqueous media. RSC Advances, 2014, 4, 28046–28051. Shao-Yong Li, Yao-Wei Xu, She-Quan Zeng, Li-Min Xiao, Hong-Quan Duan, Xue-Lian Lin, Jun-Min Liu*, Cheng-Yong Su*. Highly selective fluorescent calix[4]arene chemosensor for acidic amino acids in pure aqueous media. Tetrahedron Letters, 2012, 53, 2918-2921. Jun-Min Liu*, Jian-Ying Shi, Yao-Wei Xu, Cheng-Yong Su, Shao-Yong Li*. Synthesis of inherently chiral wide rim ABC-substituted calix[6]arene derivatives. Supramolecular Chemistry, 2011, 23, 419-424. Shao-Yong Li, Yao-Wei Xu, Jun-Min Liu*, Cheng-Yong Su. Inherently chiral calixarenes: synthesis, optical resolution, chiral recognition and asymmetric catalysis. International Journal of Molecular Sciences, 2011, 12, 429-455. Dongmao Zhang*, Karthikeshwar Vangala, Shaoyong Li, Michael Yanney, Hao Xia, Sige Zou, Andrzej Sygula. Acid cleavable surface enhanced raman tagging for protein detection. Analyst, 2011, 136, 520-526.