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Jun Zhang, Xin Liu, Shu-Qing Wang, Gui-You Liu, Wei-RenXu, Xian-Chao Cheng *, Run-Ling Wang*. Identification of dual ligands targeting angiotensin II type 1 receptor and peroxisome proliferator activated receptor-γ by core hopping of telmisartan [J]. Journal of Biomolecular Structure and Dynamics, 2016, 7, 1-16
Mei-Yan Wang, Yuan-Yuan Jin, Hui-Yu Wei, Li-Song Zhang, Su-Xia Sun, Xiu-Bo Chen, Wei-Li Dong, Wei-Ren Xu, Xian-Chao Cheng*, Run-Ling Wang*. Synthesis, biological evaluation and 3D-QSAR studies of imidazolidine-2,4-dione derivatives as novel protein tyrosine phosphatase 1B inhibitors [J]. European Journal of Medicinal Chemistry, 2015, 103, 91-104
Xue-Jiao Wang, Jun Zhang, Shu-Qing Wang, Wei-Ren Xu, Xian-Chao Cheng, Run-Ling Wang*.Identification of novel multitargeted PPARα/γ/δ pan agonists by core hopping of rosiglitazone [J]. Drug Design, Development and Therapy, 2014, 8, 2255-2262
Ying Ma, Yuan-Yuan Jin, Ye-Liu Wang, Run-Ling Wang*, Xin-Hua Lu, De-Xin Kong, Wei-Ren Xu. The Discovery of a Novel and Selective Inhibitor of PTP1B Over TCPTP: 3D-QSAR Pharmacophore Modeling, Virtual Screening, Synthesis, and Biological Evaluation [J]. Chemical Biology & Drug Design, 2014, 83, 697-709
Lan-LanZang, Xue-Jiao Wang, Xiao-Bo Li, Shu-Qing Wang, Wei-RenXu, Xian-Bin Xie, Xian-Chao Cheng, Huan Ma, Run-Ling Wang*. SAHA-based novel HDAC inhibitor design by core hopping method [J]. Journal of Molecular Graphics and Modelling, 2014, 54, 10-18
Jing-Wei Wu, Huan Zhang, Yu-Qing Duan, Wei-Li Dong, Xian-Chao Cheng, Shu-Qing Wang, Run-Ling Wang*. Design Novel Inhibitors for Treating Cancer by Targeting Cdc25B Catalytic Domain with De Novo Design [J]. Combinatorial chemistry & high throughput screening, 2014, 17(10): 837-847
Yu-Qing Duan, Ying Ma, Xue-Jiao Wang, Yuan-Yuan Jin, Run-Ling Wang*, Wei-Li Dong, Wei-Ren Xu, De-Xin Kong, Shu-Qing Wang*.Design Potential Selective Inhibitors for Treating Cancer by Targeting the Src Homology 2 (SH2) Domain-Containing Phosphatase 2 (Shp2) with Core Hopping Approach [J]. Protein & Peptide Letters, 2014, 21(6): 556-563
Yuan-Yuan Jin, Ying Ma, Quan-Xiong Gao, Run-Ling Wang*, Shu-Qing Wang, Wei-Ren Xu. Design of specific inhibitors of the protein tyrosine phosphatase SHP-2 by virtual screening and core hopping method [J]. Molecular Simulation, 2014, 40(12): 904–911
Wei-Bing Zhang, Wen-Bo Liu, Jing-Wei Wu, Wei-Li Dong, Shu-Qing Wang*, Run-Ling Wang*. The derivatives of oseltamivir design passing through the important cleft of neuraminidase against influenza virus by de novo design [J]. Molecular Simulation, 2014, 40(15): 1209–1217
Ying Ma, Su-Xia Sun, Xian-Chao Cheng, Shu-Qing Wang, Wei-Li Dong, Run-Ling Wang*, Wei-Ren Xu. Design and Synthesis of Imidazolidine-2,4-Dione Derivatives as Selective Inhibitors by Targeting Protein Tyrosine Phosphatase-1B Over T-Cell Protein Tyrosine Phosphatase [J]. Chemical Biology & Drug Design, 2013, 82(5): 595-602
Su-Xia Sun, Xiao-Bo Li, Wen-Bo Liu, Ying Ma, Run-Ling Wang*, Xian-Chao Cheng, Shu-Qing Wang, Wei Liu. Design, Synthesis, Biological Activity and Molecular Dynamics Studies of Specific Protein Tyrosine Phosphatase 1B Inhibitors over SHP-2[J]. International journal of molecular sciences, 2013, 14, 12661-12674
Lei Liu, Ying Ma, Run-Ling Wang*, Wei-Ren Xu, Shu-Qing Wang*, Kuo-Chen Chou. Find novel dual-agonist drugs for treating type 2 diabetes by means of cheminformatics [J]. Drug Design Development and Therapy, 2013, 7, 279-288
Wen-Ming Li, Xiao-Bo Li, Su-Xia Sun, Jing Liang, Run-Ling Wang*, Shu-Qing Wang. Agonist and antagonist recognition studies for oestrogen receptor by molecular dynamics Simulation [J]. Molecular Simulation, 2013, 39(3):228-233
Xian-Chao Cheng, Run-Ling Wang*, Zhen-Ke Dong, Jing Li, Yao-Yuan Li, Rong-Rong Li. Design, synthesis and evaluation of novel metalloproteinase inhibitors based on L-tyrosine scaffold [J]. Bioorganic & Medicinal Chemistry, 2012, 20, 5738–5744
Ying Ma, Shu-Qing Wang*, Wei-Ren Xu, Run-Ling Wang*, Kuo-Chen Chou. Design Novel Dual Agonists for Treating Type-2 Diabetes by Targeting Peroxisome Proliferator-Activated Receptors with Core Hopping Approach[J].PLoS ONE, 2012, 7(6): e38546
Synthesis, biological evaluation and 3D-QSAR studies of 1,2,4-triazole-5-substituted carboxylic acid bioisosteres as uric acid transporter 1 (URAT1) inhibitors for the treatment of hyperuricemia associated with gout,Jing-wei Wu, Ling Yinb, Yu-qiang Liu, Huan Zhang, Ya-fei Xie, Run-ling Wang, Gui-long Zhao，Bioorganic & Medicinal Chemistry Letters, 2019,29,383-388
Rui-Rui Wang, Ying Ma, Shan Du, Wei-Ya Li, Ying-Zhan Sun, Hui Zhou, Run-Ling Wang，Exploring the reason for increased activity of SHP2 caused by D61Y,mutation through molecular dynamics，Computational Biology and Chemistry，2019,78,133-1493
Wen-Yan Jin, Ying Ma, Wei-Ya Li, Hong-Lian Li, Run-Ling Wang*,Scaffold-based novel SHP2 allosteric inhibitors design using,Receptor-Ligand pharmacophore model, virtual screening and molecular dynamics, Computational Biology and Chemistry 2018,73 :179–188
Wei‐Ya Li，Hui‐Yu Wei，Ying‐Zhan Sun，Hui Zhou，Ying Ma, Run‐Ling Wang，Exploring the effect of E76K mutation on SHP2 cause, gain‐of‐function activity by a molecular dynamics study，J Cell Biochem. 2018，1-16.
Hong-Lian Li, Ying Ma, Ying Ma, Yu Li, Xiu-Bo Chen, Wei-Li Dong*, Run-Ling Wang*,The design of novel inhibitors for treating cancer by targeting CDC25B through disruption of CDC25B-CDK2/Cyclin A interaction using computational approaches , Oncotarget, 2017, 8 ( 20): 33225-33240
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