Garg, Neil K. - University of California, Los Angeles - Department of Chemistry & Biochemistry

个人简介

Neil is a Distinguished Professor and the inaugural holder of the Kenneth N. Trueblood Endowed Chair in Chemistry and Biochemistry. He has served as Vice Chair for the Department of Chemistry and Biochemistry (2012–2016 and 2023-present), as well as the Department Chair (2019–2023). He also served as Faculty-in-Residence in the UCLA undergraduate community for nine years. Neil is a co-founder of ElectraTect as well as a popular speaker and consultant for teaching, scientific, policy, government, and legal matters. Prior to joining the faculty at UCLA, Neil received a B.S. in Chemistry from New York University where he did undergraduate research with Professor Marc Walters. During his undergraduate years, he spent several months in Strasbourg, France while conducting research with Professor Mir Wais Hosseini at Université Louis Pasteur as a NSF REU Fellow. Neil obtained his Ph.D. in 2005 from the California Institute of Technology under the direction of Professor Brian Stoltz. He then joined Professor Larry Overman’s research laboratory at the University of California, Irvine as an NIH Postdoctoral Scholar. Neil joined the faculty at UCLA in 2007. He was promoted to Associate Professor in 2012, and then to Full Professor in 2013. In 2020, he was promoted to the rank of Distinguished Professor.

研究领域

The Garg Lab develops synthetic strategies and methods that enable the synthesis of complex bioactive molecules. Our specific interests lie primarily in three main areas: (a) transition metal-catalyzed cross-coupling reactions of unconventional electrophiles, (b) the use of historically-avoided strained intermediates, such as cyclic allenes and alkynes, in organic synthesis, and (c) the total synthesis of complex small molecules, such as drugs and natural products We also enjoy the opportunity to collaborate in areas such as natural product biosynthesis, green chemistry, solar cell technologies, THC detection, and studies of fundamental reactivity.

近期论文

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Small molecule inhibition of RNA binding proteins in haematologic cancer. Amit K Jaiswal, Michelle L Thaxton, Georgia M Scherer, Jacob P Sorrentino, Neil K Garg, Dinesh S Rao. RNA biology, 2024, 21 (1), 1-14 Organic chemistry for kids. Arismel Tena Meza, Laura G Wonilowicz, Neil K Garg. Nature Reviews Chemistry, 2024, 1-2 Fragment-Guided Genome Mining of Octacyclic Cyclophane Alkaloids from Fungi. Yalong Zhang, Lin Wu, Tyler A Kerr, Neil K Garg, Yi Tang. Journal of the American Chemical Society, 2024 Diels–Alder Cycloadditions of Oxacyclic Allenes and α-Pyrones. Laura G Wonilowicz, Milauni M Mehta, Lisa L Kamecke, Sarah A French, Neil K Garg. Organic Letters, 2024, 26 (30), 6465-6470 Access to Complex Scaffolds Through [2+ 2] Cycloadditions of Strained Cyclic Allenes. Matthew S McVeigh, Jacob P Sorrentino, Allison T Hands, Neil K Garg. Journal of the American Chemical Society, 2024 Total Synthesis of Lissodendoric Acid A. Francesca M Ippoliti, Laura G Wonilowicz, Nathan J Adamson, Evan R Darzi, Joyann S Donaldson, Daniel J Nasrallah, Milauni M Mehta, Andrew V Kelleghan, KN Houk, Neil K Garg. Angewandte Chemie International Edition, 2024, e202406676 Evaluation of Retro-Aldol vs Retro-Carbonyl-Ene Mechanistic Pathways in a Complexity-Generating C–C Bond Fragmentation. Ana S Bulger, Daniel W Turner, Qingyang Zhou, KN Houk, Neil K Garg. Organic Letters, 2024, 26 (17), 3602-3606 Generation and reactivity of unsymmetrical strained heterocyclic allenes. Andrew V Kelleghan, Arismel Tena Meza, Neil K Garg. Nature Synthesis, 2024, 3 (3), 329-336 Enantioselective nickel-catalyzed Mizoroki–Heck cyclizations of amide electrophiles. Ana S Bulger, Daniel J Nasrallah, Arismel Tena Meza, Neil K Garg. Chemical Science, 2024, 15 (7), 2593-2600 Correction to “Electrochemical Oxidation of Δ9-Tetrahydrocannabinol: A Simple Strategy for Marijuana Detection”. Evan R Darzi, Neil K Garg. Organic Letters, 2023, 25 (43), 7946-7946 Studies pertaining to the emerging cannabinoid hexahydrocannabinol (HHC). Daniel J Nasrallah, Neil K Garg. ACS chemical biology, 2023, 18 (9), 2023-2029 Electrochemical Oxidation of Δ9-Tetrahydrocannabinol at Nanomolar Concentrations. Christina R Forbes, Katie A Spence, Neil K Garg, Evan R Darzi. The Journal of Organic Chemistry, 2023, 88 (15), 11358-11362 Cyclic allene approach to the manzamine alkaloid keramaphidin B. Milauni M Mehta, Jordan AM Gonzalez, James L Bachman, Neil K Garg. Organic Letters, 2023, 25 (30), 5553-5557 Total Synthesis of Phenanthroindolizidines Using Strained Azacyclic Alkynes. Katie A Spence, Marie Hoffmann, Neil K Garg. Organic Letters, 2023, 25 (27), 5044-5048 Strain-promoted reactions of 1, 2, 3-cyclohexatriene and its derivatives. Andrew V Kelleghan, Ana S Bulger, Dominick C Witkowski, Neil K Garg. Nature, 2023, 618 (7966), 748-754 Elucidating the molecular programming of a nonlinear non-ribosomal peptide synthetase responsible for fungal siderophore biosynthesis. Matthew Jenner, Yang Hai, Hong H Nguyen, Munro Passmore, Will Skyrud, Junyong Kim, Neil K Garg, Wenjun Zhang, Rachel R Ogorzalek Loo, Yi Tang. Nature Communications, 2023, 14 (1), 2832 Catalyst-controlled annulations of strained cyclic allenes with π-allylpalladium complexes. Dominick C Witkowski, Matthew S McVeigh, Georgia M Scherer, Sarah M Anthony, Neil K Garg. Journal of the American Chemical Society, 2023, 145 (19), 10491-10496 Total synthesis of lissodendoric acid A via stereospecific trapping of a strained cyclic allene. Francesca M Ippoliti, Nathan J Adamson, Laura G Wonilowicz, Daniel J Nasrallah, Evan R Darzi, Joyann S Donaldson, Neil K Garg. Science, 2023, 379 (6629), 261-265 Facile synthesis of 2-aza-9, 10-diphenylanthracene and the effect of precise nitrogen atom incorporation on OLED emitters performance. Evan R Darzi, Dane A Stanfield, Luca McDermott, Andrew V Kelleghan, Benjamin J Schwartz, Neil K Garg. Materials Advances, 2023, 4 (15), 3351-3355 A symmetry-driven approach toward the total synthesis of dodecahedrane. Jason V Chari, Luca McDermott, Jacob E Dander, Bryan J Simmons, Neil K Garg. Tetrahedron, 2022, 126, 133041 Mentoring is more important than ever. Jennifer M. Heemstra, Neil K Garg. Nature Reviews Chemistry, 2022, 6 (11), 757-758 A Cannabinoid Fuel Cell Capable of Producing Current by Oxidizing Δ9-Tetrahydrocannabinol. D Huang, Christina R. Forbes, Neil K. Garg, Evan R. Darzi. Organic Letters 2022, 24 (37), 6705-6710 Merging Metals and Strained Intermediates. Katie A. Spence,† Arismel Tena Meza,† and Neil K. Garg. Chem Catalysis 2022, 2, 1–10. DOI: 10.1016/j.checat.2022.06.014 Gaming Stereochemistry. Francesca M. Ippoliti, Melinda M. Nguyen, Amber J. Reilly, and Neil K. Garg. Nature Reviews Chemistry 2022, DOI: DOI: 10.1038/s41570-022-00395-5 pi-Extension of Heterocycles via a Pd-Catalyzed Heterocyclic Aryne Annulation: pi-Extended Donors for TADF Emitters. Katie A. Spence,† Jason V. Chari,† Mattia Di Niro, Robert B. Susick, Narcisse Ukwitegetse, Peter I. Djurovich, Mark E. Thompson, and Neil K. Garg. Chem. Sci. 2022, 13, 5884–5892. Advancing Global Chemical Education Through Interactive Teaching Tools. Francesca M. Ippoliti,† Jason V. Chari,† and Neil K. Garg. Chem. Sci. 2022, 13, 5790–5796. Catalysis in Modern Drug Discovery: Insights from a Graduate Student-Taught Undergraduate Course. Jason V. Chari,† Rachel R. Knapp,† Timothy B. Boit, and Neil K. Garg. J. Chem. Educ. 2022, 99, 1296–1303. Interception of 1,2-Cyclohexadiene with TEMPO Radical. Matthew S. McVeigh and Neil K. Garg. Tetrahedron Lett. 2021, 87, 153539–153543 A Convenient Method for the Removal of Tetrabutylammonium Salts from Desilylation Reactions. Luca McDermott, Dominick C. Witkowski, and Neil K. Garg. Org. Synth. 2022, 99, 53–67. Synthesis of Phenanthridinones via the Palladium-Catalyzed Annulation of Benzyne. Dominick C. Witkowski, Luca McDermott, and Neil K. Garg. Org. Synth. 2022, 99, 159–173. Synthesis of Carboxylic Acids from Benzamide Precursors Using Nickel Catalysis. Ana S. Bulger, Dominick C. Witkowski, and Neil K. Garg. Org. Synth. Submitted. Cell-Free Total Biosynthesis of Plant Terpene Natural Products using an Orthogonal Cofactor Regeneration System. Undramaa Bat-Erdene, John M. Billingsley, William C. Turner, Benjamin R. Lichman, Francesca M. Ippoliti, Neil K. Garg, Sarah E. O’Connor, and Yi Tang. ACS Catal. 2021, 11, 9898–9903. Cycloaddition Cascades of Strained Alkynes and Oxadiazinones. Melissa Ramirez, † Evan Darzi, † Joyann Donaldson, Kendall N. Houk, Neil K. Garg. Angew. Chem., Int. Ed. 2021, 60, 18201–18208. Leveraging Fleeting Strained Intermediates to Access Complex Scaffolds. Sarah M. Anthony, Laura G. Wonilowicz,† Matthew S. McVeigh,† and Neil K. Garg* JACS Au 2021, 1, 897–912. Palladium-Catalyzed Annulations of Strained Cyclic Allenes. Andrew V. Kelleghan, Dominick C. Witkowski, Matthew S. McVeigh, Neil K. Garg. J. Am. Chem. Soc. 2021, 143, 25, 9338–9342. A Platform for On-the-Complex Annulation Reactions with Transient Aryne Intermediates. Jason V. Chari,† Katie A. Spence,† Robert B. Susick, and Neil K. Garg. Nat. Commun. 2021, 12, 3706. Total Synthesis of (−)-Strictosidine and Interception of Aryne Natural Product Derivatives “Strictosidyne” and “Strictosamidyne”. Sarah M. Anthony,† Veronica Tona,† Yike Zou,† Lucas A. Morrill, John M. Billingsley, Megan Lim, Yi Tang,* K. N. Houk,* Neil K. Garg* J. Am. Chem. Soc. 2021, 143, 10, 7471–7479. Origins of Endo Selectivity in Diels–Alder Reactions of Cyclic Allene Dienophiles. Melissa Ramirez, Dennis Svatunek, Fang Liu, Neil K. Garg, and K. N. Houk. Angew. Chem., Int. Ed. 2021, 60, 14989–14997. Palladium-Catalyzed Acetylation of Arylbromides. Milauni M. Mehta, Andrew V. Kelleghan, and Neil K. Garg. Org. Synth. 2021, 98, 68-83 Taming Radical Pairs in the Crystalline Solid State: Discovery and Total Synthesis of Psychotriadine. Jordan J. Dotson, Ieva Liepuoniute, J. Logan Bachman, Vince M. Hipwell, Saeed I. Khan, K. N. Houk*, Neil K. Garg*, and Miguel A. Garcia-Garibay.* J. Am. Chem. Soc. 2021, 143, 10, 4043–4054. The Adult Organic Coloring Book. Jacob E. Dander,† Evan R. Darzi,† and Neil K. Garg Cyanoamidine Cyclization Approach to Remdesivir’s Nucleobase. Rachel R. Knapp,† Veronica Tona,† Taku Okada, Richmond Sarpong, and Neil K. Garg. Org. Lett. 2020, 22, 8430–8435. Reductive Arylation of Amides via a Nickel‐Catalyzed Suzuki–Miyaura Coupling and Transfer Hydrogenation Cascade. Timothy Boit,† Milauni M. Mehta,† Junyong Kim, Emma L. Baker, and Neil K. Garg. Angew. Chem., Int. Ed. 2021, 60, 2472–2477 Activation of C–O and C–N Bonds Using Non-Precious-Metal Catalysis. Timothy Boit,† Ana, S. Bulger,† Jacob E. Dander,† and Neil K. Garg. ACS Catalysis 2020, 10, 12109–12126. An Enzymatic Alder-Ene Reaction. Masao Ohashi, Cooper S. Jamieson, Yujuan Cai, Dan Tan, Daiki Kanayama, Man-Cheng Tang, Sarah M. Anthony, Jason V. Chari, Joyann S. Barber, Elias Picazo, Thomas B. Kakule, Shugeng Cao, Neil K. Garg, Jiahai Zhou, K. N. Houk, and Yi Tang. Nature 2020, 586, 64–69. Intercepting Fleeting Cyclic Allenes with Asymmetric Nickel Catalysis. Michael M. Yamano,† Andrew V. Kelleghan,† Qianzhen Shao,† Maude Giroud, Bryan J. Simmons, Bo Li, Shuming Chen, K. N. Houk, and Neil K. Garg. Nature 2020, 586, 242–247. The Organic Coloring Book: Cheesy Goes to the Doctor. Kaylie Garg,† Elaina Garg,† and Neil K. Garg. Putting Mentoring First. Jen Heemstra and Neil Garg. Chemical & Engineering News 2020, 98, Treating a Global Health Crisis with a Dose of Synthetic Chemistry. Melissa A. Hardy, Brandon A. Wright, J. Logan Bachman, Timothy B. Boit, Hannah M. S. Haley, Rachel R. Knapp, Robert F. Lusi, Taku Okada, Veronica Tona, Neil K. Garg*, and Richmond Sarpong.* ACS Cent. Sci. 2020, 6, 1017–1030. Discovery and Total Synthesis of a Bis(Cyclotryptamine) Alkaloid Bearing the Elusive Piperidinoindoline Scaffold. Jordan J. Dotson, J. Logan Bachman, Miguel A. Garcia-Garibay, Neil K. Garg. J. Am. Chem. Soc. 2020, 142, 11685–11690. Silyl Tosylate Precursors to Cyclohexyne, 1,2-Cyclohexadiene, and 1,2-Cycloheptadiene. Matthew S. McVeigh, Andrew V. Kelleghan, Michael M. Yamano, Rachel R. Knapp, and Neil K. Garg. Org. Lett. 2020, 22, 4500–4504. Evaluation of the photodecarbonylation of crystalline ketones for the installation of reverse prenyl groups on the pyrrolidinoindoline scaffold. Jordan J. Dotson, Neil K. Garg, and Miguel A. Garcia Garibay. Tetrahedron 2020, 76, 131181. Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer’s Disease. Tina Bilousova, Bryan J. Simmons, Rachel R. Knapp, Chris J. Elias, Jesus Campagna, Mikhail Melnik, Sujyoti Chandra, Samantha Focht, Chunni Zhu, Kanagasabai Vadivel, Barbara Jagodzinska, Whitaker Cohn, Patricia Spilman, Karen H. Gylys, Neil K. Garg, and Varghese John. ACS Chem. Biol. 2020, 15, 1671–1684. Electrochemical Oxidation of Δ9-Tetrahydrocannabinol: A Simple Strategy for Marijuana Detection. Evan R. Darzi and Neil K. Garg. Org. Lett. 2020, 22, 3951–3955 Nickel-Catalyzed Conversion of Amides to Carboxylic Acids. Rachel R. Knapp, Ana S. Bulger, and Neil K Garg. Org. Lett. 2020, 22, 2833–2837. Ni-Catalyzed Suzuki–Miyaura Cross-Coupling of Aliphatic Amides on the Benchtop. Milauni M. Mehta, Timothy B. Boit, Jacob E. Dander, and Neil K. Garg. Org. Lett. 2020, 22, 1–5. Total Synthesis as a Vehicle for Collaboration. Lucas A. Morrill, Robert B. Susick, Jason V. Chari, and Neil K. Garg. J. Am. Chem. Soc. 2019, 141, 12423–12443. Chemoenzymatic Conversion of Amides to Enantioenriched Alcohols in Aqueous Medium. Jacob E. Dander, Maude Giroud, Sophie Racine, Oscar Alvizo, David Entwistle, and Neil K. Garg. Communications Chemistry, 2019, 2, 82. Cyclic Alkyne Approach to Heteroatom-Containing Polycyclic Aromatic Hydrocarbon Scaffolds. Evan R. Darzi, Joyann S. Barber, and Neil K. Garg. Angew. Chem. Int. Ed. 2019, 58, 9419–9424. Cycloadditions of Oxacyclic Allenes and a Catalytic Asymmetric Entryway to Enantioenriched Cyclic Allenes. Michael M. Yamano, Rachel R. Knapp, Aurapat Ngamnithiporn, Melissa Ramirez, K. N. Houk, Brian M. Stoltz, and Neil K. Garg. Angew. Chem. Int. Ed. 2019, 58, 5653–5657. Diels–Alder Cycloadditions of Strained Azacyclic Allenes. Joyann S. Barber, Michael M. Yamano, Melissa Ramirez, Evan R. Darzi, Rachel R. Knapp, Fang Liu, K. N. Houk, and Neil K. Garg. Nature Chemistry 2018 10, 953–960. Arynes and Cyclic Alkynes as Synthetic Building Blocks for Stereodefined Quaternary Centers. Elias Picazo, Sarah M. Anthony, Maude Giroud, Adam Simon, Margeaux A. Miller, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2018, 140, 7605–7610. Enantioselective Total Syntheses of Methanoquinolizidine-Containing Akuammiline Alkaloids and Related Studies. Elias Picazo, Lucas A. Morrill, Robert B. Susick, Jesus Moreno, Joel Smith, and Neil K. Garg. J. Am. Chem. Soc. 2018, 140, 6483–6492.