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个人简介

教育背景 1987年09月—1994年07月:天津师范大学化学系获得理学学士、硕士学位 2000年09月—2003年07月:南开大学生物无机化学专业获得理学博士学位 2003年10月—2004年09月:法国巴黎十一大学 (University Paris-sub XI)分子材料研究所博士后 2004年09月—2005年08月:德国李比希大学 (Justus-Liebig-University), DFG资助博士后 工作经历 1994年07月—至今:天津医科大学药学院任职从事教学、科研工作 2006年10月—至今:教授、博士生导师 2010年07月—2011年07月:美国麻省理工学院 (MIT) 化学系,访问教授 2012年09月—2016年08月:入选天津市特聘教授 2012年12月—2016年11月:入选天津市中青年骨干创新人才培养计划 2014年05月—至今:药学院副院长、药学院党委委员 荣誉奖励 2012年,天津市特聘教授 2012年,天津市高校中青年骨干创新人才 2011年,天津医科大学校聘一级关键岗位 2009年,天津医科大学药学院优秀教师 2009年,天津医科大学校聘二级关键岗位 2007年,天津市自然科学三等奖,第一完成人 2007年,天津医科大学优秀教师 2007年,天津医科大学“十一五”新世纪人才 1999年,天津医科大学优秀教师

研究领域

药物化学 化学生物学

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.Three Pt(II) complexes based on Thiosemicarbazone: synthesis, HSA interaction, cytotoxicity, apoptosis and cell cycle arrest. RSC Advances, 2017, 7, 26478 – 26486. 2.A new mixed-ligand copper(II) complex inhibits growth and induces apoptosis by DNA targeting in human epithelial cervical cancer cells. Appl. Organometal. Chem. 2016, 31(7),e3651. 3.Mixed-ligand copper(II) Schiff base complexes: the role of co-ligand in DNA binding, DNA cleavage, protein binding and cytotoxicity. Dalton Trans., 2016, 45, 9073–9087. 4.Four Cu(II) complexes based on antitumor chelators: synthesis, structure, DNA binding/ damage, HSA interaction and enhanced cytotoxicity. Dalton Trans., 2016, 45, 8036–8049. 5.Novel Zn(II)-thiazolone-based Solid Fluorescent Chemosensors: Naked-eye Detection for Acid/Base and Toluene. RSC Advances, 2016, 6, 52310–52317. 6.Two dpa-based zinc(II) complexes as potential anticancer agents: nuclease activity, cytotoxicity and apoptosis studies. New J. Chem., 2016, 40, 7513-7521. 7.Association of structural modifications with bioactivity in three new copper(II) complexes of Schiff base ligands derived from 5-chlorosalicylaldehyde and amino acids. Journal of Inorganic Biochemistry, 2015, 146, 52–60. 8.Fourrelatedmixed-ligandnickel(II) complexes: effect of steric encumbrance on the structure, DNA/BSA binding, DNA cleavage and cytotoxicity. RSC Adv., 2015, 5, 30768–30779. 9.Thiosemicarbazone Cu(II) and Zn(II) Complexes as Potential Anticancer Agents: Syntheses, Crystal Structure, DNA Cleavage, Cytotoxicity and Apoptosis Induction Activity. Journal of Inorganic Biochemistry, 2014, 136, 13–23. 10. Biological evaluation of a cytotoxic 2-substitued benzimidazole copper(II) complex: DNA damage, antiproliferation and apoptotic induction activity in human cervical cancer cells. Biometals,2014, 27:155–172. 11. Nuclease activity and protein-binding properties of a novel tetranuclear thiosemicarbazide Pt(II) complex. Dalton Trans.,2014, 43, 1663–1671. 12. Two Polypyridyl Copper(II) Complexes: Synthesis, Crystal Structure and Interaction with DNA and Serum Protein in vitro.New J. Chem., 2014, 38, 955-965. 13. A New Enneanuclear Nickel(II) Cluster with a Rectangular Face-Centered Trigonal Prism Structure and Cluster Glass Behavior. Chem. Commun., 2012, 48, 1015–1017. 14. Two new dicopper(II) complexes with oxamido-bridged ligand: Synthesis, crystal structures, DNA binding/cleavage and BSA binding activity. J. Inorg. Biochem.,2012, 115, 78-86. 15. Activities of a novel Schiff Base copper(II) complex on growth inhibition and apoptosis induction toward MCF-7 human breast cancer cells via mitochondrial pathway. J. Inorg. Biochem.,2012,117, 1-9. 16. Study on potential antitumor mechanism of a novel Schiff Base copper(II) complex: synthesis, crystal structure, DNA binding, cytotoxicity and apoptosis induction activity, J. Inorg. Biochem.,2011, 105, 728-737. 17. Directed Assembly and Characterization of 1D Polymers Based on [MII(BMA)]2+ Node (M = Cu, Mn, Ni and Zn; BMA = N,N-bis (benzimidazol-2-yl-methyl)amine) with Linear Bridging Dicyanamide and Terephthalate Ligands, Dalton Trans.,2010, 39, 7159 - 7166. 18. Self-assembly and magnetic properties of a Ni(II)8(m4-hydroxo)6 cube with m2-Pyrazolate as exogeneous anchillary ligand, Chem. Commun., 2008, 6414-6416. 19. Syntheses, Structures and Properties of Novel Cage-Like Complexes Based on Dodeca- nuclear Lanthanide with a Large Cavity. Crystal Growth & Design2007, 7(6), 1044-1048. 20. Iron(III) Complexes with the Ligands N’,N’-bis[(2-pyridyl)methyl]ethylene diamine (uns-penp) and the Amide N-Acetyl-N’,N’-bis[(2-pyridyl)methyl]ethylenediamine (acetyl-uns-penp)”. Eur. J. Inorg. Chem. 2006, 1601-1610.

学术兼职

Chem. Commun., J. Inorg. Biochem., Inorg. Chem., Dalton Trans., Eur J. Chem., Biometals等国际期刊审稿人、国家自然科学基金委员会函审专家、教育部学位与研究生教育评审专家、浙江、广东省等自然科学基金委员会函审专家、中国化学会、药学会会员等。

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