钟超 - 北京大学 - 基础医学院

个人简介

2002-2006年中国科学技术大学学士 2006-2012年中国科学院生物物理研究所博士 2012-2016年美国国立卫生研究院博士后/交流访问学者 2016年- 北京大学基础医学院，系统生物医学研究所研究员

研究领域

黏膜组织（mucosal tissue），包括肠道、呼吸道等，担负着保障机体与外界正常交流的重要作用。黏膜组织内部的免疫系统在维系组织免疫平衡、防御病源入侵等过程中发挥着非常重要的作用，是目前免疫学研究的热点。天然淋巴细胞（innate lymphoid cell，或ILC）是黏膜组织中大量富集的一类免疫细胞。我们希望从对ILC的研究入手，利用荧光基因报告小鼠、功能基因敲除模型、多色流式细胞分析、高通量测序、感染及肿瘤模型等手段，揭示黏膜组织中免疫系统的功能特点、调控机制及其发育过程。具体而言包括下述内容： 1.阐释重要转录因子对黏膜组织中免疫细胞（如ILC、T细胞等）发育、分化及功能的调控机制并根据关键转录因子的表达情况发现新的免疫细胞亚群； 2.揭示黏膜组织中免疫细胞之间的相互作用关系； 3.探索肠道表皮细胞、共生菌群对肠道免疫细胞的影响。

近期论文

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1. Zhong, C., Cui, K., Wilhelm, C., Hu, G., Mao, K., Belkaid, Y., Zhao, K., and Zhu, J. (2016). Group 3 innate lymphoid cells continuously require the transcription factor GATA-3 after commitment. Nature immunology 17, 169-178. 2. Sojka, D.K., Plougastel-Douglas, B., Yang, L., Pak-Wittel, M.A., Artyomov, M.N., Ivanova, Y., Zhong, C., Chase, J.M., Rothman, P.B., Yu, J., et al. (2014). Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells. eLife 3, e01659. 3. Yagi, R.＃, Zhong, C.＃, Northrup, D.L.＃, Yu, F., Bouladoux, N., Spencer, S., Hu, G., Barron, L., Sharma, S., Nakayama, T., et al. (2014). The transcription factor GATA3 is critical for the development of all IL-7Ralpha-expressing innate lymphoid cells. Immunity 40, 378-388. (＃，equal contribution) 4. Zhong, C., and Zhu, J. (2017). Small-Molecule RORγt Antagonists: One Stone Kills Two Birds. Trends Immunol. 38(4), 229-231. (invited review) 5. Zhong, C., and Zhu, J. (2015). Transcriptional Regulatory Network for the Development of Innate Lymphoid Cells. Mediators of inflammation 2015, 264502. (invited review) 6. Zhong, C., and Zhu, J. (2015). Bcl11b drives the birth of ILC2 innate lymphocytes. The Journal of experimental medicine 212, 828. (preview) 7. Zhong, C., and Zhu, J. (2015). Tet2: breaking down barriers to T cell cytokine expression. Immunity 42, 593-595. (preview) 8. Zhong, C., Li, C., Wang, X., Toyoda, T., Gao, G., and Fan, Z. (2012). Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin alpha1/beta dimer of infected host cells. Cell death and differentiation 19, 882-890. 9. Zhang, H., Zhong, C., Shi, L., Guo, Y., and Fan, Z. (2009). Granulysin induces cathepsin B release from lysosomes of target tumor cells to attack mitochondria through processing of bid leading to Necroptosis. Journal of immunology 182, 6993-7000. 10. Hua, G., Wang, S., Zhong, C., Xue, P., and Fan, Z. (2009). Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis. Journal of immunology 182, 2152-2159.