游富平 - 北京大学 - 基础医学院

个人简介

2019 12-今北京大学系统生物医学研究所，副所长，长聘研究员 2014 12-2019 12 北京大学系统生物医学研究所，研究员，国家海外引进青年人才 2013 06-2014 12 耶鲁大学医学院，副研究员 2011 08-2013 06 耶鲁大学医学院，博士后 2006 09-2011 07 北京大学生命科学学院博士研究生

研究领域

研究模式识别如何调节天然免疫和细胞死亡，及其在抗病毒、肿瘤发生过程中的功能和分子机制，为相关疾病的治疗提供理论基础和治疗靶点。

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1 Cao L, Luo Y, Guo X, Liu S, Li S, Li J, Zhang Z, Zhao Y, Zhang Q, Gao F, Ji X, Gao X, Li Y, You F. SAFA facilitates chromatin opening of immune genes through interacting with anti-viral host RNAs. PLoS Pathog. 2022 Jun 3;18(6). 2 Chen B, Yan Y, Yang Y, Cao G, Wang X, Wang Y, Wan F, Yin Q, Wang Z, Li Y, Wang L, Xu B, You F*, Zhang Q*, Wang Y*. A pyroptosis nanotuner for cancer therapy. Nat Nanotechnol. 2022 May 23. 3 Sun Y, Gong L, Yin Y, Zhang L, Sun Q, Feng K, Cui Y, Zhang Q, Zhang X, Deng X, You F*, Lu D*, Lin Z*. A gradient pH-sensitive polymer-based antiviral strategy via viroporin-induced membrane acidification. Adv Mater. 2022 Feb 28. 4 Chen J, Wei X, Wang X, Liu T, Zhao Y, Chen L, Luo Y, Du H, Li Y, Liu T, Cao L, Zhou Z, Zhang Z, Liang L, Li L, Yan X, Zhang X, Deng X, Yang G, Yin P, Hao J, Yin Z, You F. TBK1-METTL3 axis facilitates antiviral immunity. Cell Rep. 2022 Feb 15;38(7):110373. 5 Zhao Y, Kuang M, Li J, Zhu L, Jia Z, Guo X, Hu Y, Kong J, Yin H, Wang X, You F. SARS-CoV-2 spike protein interacts with and activates TLR4. Cell Res. 2021 Mar 19. 6 Li S, Kuang M, Chen L, Li Y, Liu S, Du H, Cao L, You F. The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling. Cell Rep. 2021 Jan 19;34(3):108631. 7 Song J, Liu T, Yin Y, Zhao W, Lin Z, Yin Y, Lu D, You F. The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity. EMBO Rep. 2021 Feb 3;22(2):e51162. doi: 10.15252/embr.202051162. Epub 2021 Jan 4. 8 Guo Q, Zhao Y, Li J, Liu J, Yang X, Guo X, Kuang M, Xia H, Zhang Z, Cao L, Luo Y, Bao L, Wang X, Wei X, Deng W, Wang N, Chen L, Chen J, Zhu H, Gao R, Qin C, Wang X, You F. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe. 2021 Feb 10;29(2):222-235.e4. 9 Cao L, Liu S, Li Y, Yang G, Luo Y, Li S, Du H, Zhao Y, Wang D, Chen J, Zhang Z, Li M, Ouyang S, Gao X, Sun Y, Wang Z, Yang L, Lin R, Wang P, You F. The Nuclear Matrix Protein SAFA Surveils Viral RNA and Facilitates Immunity by Activating Antiviral Enhancers and Super-enhancers. Cell Host Microbe. 2019 Sep 11;26(3):369-384.e8. 10 Cao L, Yang G, Gao S, Jing C, Montgomery R., Yin Y, Wang P, Fikrig E, You F. HIPK2 is necessary for type I interferon–mediated antiviral immunity. Science Signaling. 2019 Mar 19;12(573). 11 You F, Wang P, Yang L, Yang G, Zhao Y, Qian F, Walker W , Sutton R, Montgomery R, Lin R, Iwasaki A, Fikrig E. ELF4 is critical for induction of type I interferon and the host antiviral response. Nature Immunology. 2013 Dec; 14(12):1237-46. 12 Chen H*, Sun H*, You F*, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z. Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity. Cell. 2011 Oct 14; 147(2): 436-46. 13 You F, Sun H, Zhou X, Sun W, Liang S, Zhai Z, Jiang Z. PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nature Immunology. 2009 12: 1300-1308.