个人简介
北京大学基础医学院药理学系研究员,药理学专业博士生导师。兼任北京大学分子心血管教育部重点实验室PI,血管医学卫生部重点实验室PI。2004年毕业于中国药科大学获理学博士学位。2008-2010年美国密西根大学安娜堡分校医学院博士后研究员。台湾大学客座教授,石河子大学“绿洲学者”讲座教授。担任中国药理学会心血管药理专业委员会委员,中国药理学会生化与分子药理专业委员会委员,中国药理学会表观遗传专业委员会委员。主持1项科技部重大研发计划,7项国家自然科学基金等科研项目的研究。近五年在 Br J Pharmacol , Nanomedicine-NBM , Adv Healthc Mater 等相关研究领域的优秀国际期刊上,以通讯作者共发表SCI论文30篇。研究论文曾荣获北京大学医学部优秀SCI论文引用奖、基础医学院优秀SCI论文奖及论文引用奖等荣誉
研究领域
研究兴趣主要是心血管疾病的防治与新药研究。从天然或合成的小分子化合物中,发现对心脏和血管重构有抑制作用的小分子药物,明确药物的作用机制与靶点,并设计药物的体内递送系统以提高药物的生物利用度及药效作用。目前的研究主要集中在通过调控炎症和氧化应激通路相关靶点干预心脏和血管重构的药物研究
近期论文
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1. Hu R(#), Liu S, Anwaier G, Wang QY, Shen WL, Shen Q, Qi R*. Formulation and Intestinal Absorption of Naringenin Loaded Nanostructured Lipid Carrier and Its Inhibitory Effects on Nonalcoholic Fatty Liver Disease. Nanomedicine-NBM , 2021 Feb;32:102310. doi: 10.1016/j.nano.2020.102310. Epub 2020 Oct 24. (IF: 6.458)
2. Wang QY(#), Ou YJ, Hu GM, Wen C, Yue SS, Chen C, Xu L, Xie J, Dai H, Xiao H, Zhang YY, Qi R*. Naringenin attenuates nonalocholic fatty liver disease by downregulating NLRP3/NF-κB pathway in mice. Br J Pharmacol . 2020 Apr;177(8):1806-1821. doi: 10.1111/bph.14938. (IF: 8.739)
3. Chen C(#), Wang YX(#), Cao YN, Wang QY, Anwaier G, Zhang Q, Qi R*. Inhibitory effects and mechanism of probucol on elastase-induced abdominal aortic aneurysm in mice. Br J Pharmacol . 2020 Jan;177(1):204-216. doi: 10.1111/bph.14857. (IF: 8.739)
4. Wang YX(#), Chen C, Wang QY, Cao YN, Xu L, Qi R*. Inhibitory Effects of Cycloastragenol on Abdominal Aortic Aneurysm and its Related Mechanisms. Br J Pharmacol . 2019 Jan;176(2):282-296. doi: 10.1111/bph.14515. (IF="6.81)
5. Yu MM(#), Dong AJ(#), Chen C, Xu S, Cao YN, Liu S, Zhang Q, Qi R*, Thermosensitive Hydrogel Containing Doxycycline Exerts Inhibitory Effects on Abdominal Aortic Aneurysm Induced By Pancreatic Elastase in Mice, Adv Healthc Mater . 2017 Nov 6;(22). doi: 10.1002/adhm.201700671. (IF 5.76)
6. Tuerdi N, Xu L, Zhu BL, Chen C, Cao YN, Wang YX, Zhang Q, Li ZJ, Qi R*. Preventive effects of simvastatin nanoliposome on isoproterenol-induced cardiac remodeling in mice. Nanomedicine-NBM . 2016, 2(7):1899-1907. doi: 10.1016/j.nano.2016.05.002. (IF 6.16)
7. Qi R#*, Li YZ, Chen C, Cao YN, Yu MM, Xu L, He B, Jie X, Shen WW, Wang YN, van Dongen MA, Liu GQ, Banaszak Holl MM, Zhang Q, Ke X.G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol. J Control Release . 2015 Jul 28;210:160-8. doi: 10.1016/j.jconrel.2015.05.281. (IF 7.26)
8. Tang Y, Li YB, Wang B, Lin RY, van Dongen M, Zurcher DM, Gu XY, Banaszak Holl MM, Liu GQ, Qi R*. Efficient in vitro siRNA delivery and potent gene silencing in vivo using PEG-modified PAMAM dendrimers. Mol Pharm , 2012, 9: 1812-1821. doi: 10.1021/mp3001364. (IF 5.4)
9. Qi R#, Gao Y, Tang Y, He RR, Liu TL, He Y, Sun S, Li BY, Li YB, Liu G. PEG-conjugated PAMAM dendrimers mediate efficient intramuscular gene expression. AAPS J , 2009, 11(3): 395-405. (IF 5.52)
10. Zhang XH#, Qi R#, Xian XD, Yang F, Blackstein M, Deng X, Fan JL, Ross C, Karasinska J, Hayden MR, Liu GQ. Spontaneous Atherosclerosis in Aged Lipoprotein Lipase–Deficient Mice With Severe Hypertriglyceridemia on a Normal Chow Diet. Circulation Res , 2008, 102 (2): 250-256. (IF 9.99)