张永鹤 - 北京大学 - 基础医学院

个人简介

张永鹤，北京大学二级教授，博士生导师，基础医学院药理学系副主任，北京大学医学部睡眠医学中心副主任。中国药理学会秘书长，教学与科普专业委员会主任委员，补益药专业委员会副主任委员；中国民族医药学会药理与毒理学分会执行会长；国家科技进步奖、教育部、科技部、科协、国自然及北京、上海、天津、广东等省市科技项目和科技奖评审专家。Biomolecules & Therapeutics(SCIE) 等杂志编委；主持国家自然科学基金、国家“重大新药创制”科技重大专项“十一五”候选药及“十三五”临床前研究项目、教育部基金、北京市科委-中关村医药创新品种及平台培育项目、美国中华医学基金等。自1983年以来，先后从事天然药物化学，心血管药理学和神经精神药理学的研究工作。已在国内外杂志上发表论文100余篇，作为副主编出版著作2本，译著（副主译）1本，参编10本。获美国专利授权1项、国际专利8项、中国专利2项。

研究领域

1．神经精神药理学——睡眠障碍共病(抑郁、AD、PTSD)模型建立及其神经环路机制； 2．中药与天然产物新药筛选与开发

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1) Zhang G, Liu R, Sheng ZF, Zhang YH*, Fan D*. SIRT1 Interacts with Prepro‐Orexin in the Hypothalamus in SOD1G93A Mice. Brain Sci. 2022, 12(4): 490. https://doi.org/10.3390/brainsci12040490. 2) Hui Ding, Su-Ying Cui, Xiang-Yu Cui, Yu-Tong Liu, Xiao Hu, Hui-Ling Zhao, Yu Qin, Nurhumar Kurban, Yong-He Zhang*. Anti-stress effects of combined block of glucocorticoid and mineralocorticoid receptors in the paraventricular nucleus of the hypothalamus. Br J Pharmacol 2021, 178(8):3696-3707. https://doi.org/10.1111/bph.15511. 3) Hui-Ling Zhao, Su-YingCui, YuQin, Yu-Tong Liu, Xiang-Yu Cui, Xiao Hu, Nurhumar Kurban, Ming-Yan Li, Zhen-Hao Li, Jing Xu, Yong-He Zhang∗. Prophylactic eﬀects of sporoderm-removed Ganoderma lucidum spores in a rat model of streptozotocin-induced sporadic Alzheimer's disease. J Ethnopharmacol 2021, 269:113725. https://doi.org/10.1016/j.jep.2020.113725 4) Su-Ying Cui, Yuan-Li Huang, Xiang-Yu Cui, Hui-Ling Zhao, Xiao Hu, Yu-Tong Liu, Yu Qin, Nurhumar Kurban, Yong-He Zhang*. A common neuronal mechanism of hypertension and sleep disturbances in spontaneously hypertensive rats: Role of orexinergic neurons. Prog Neuropsychopharmacol Biol Psychiatry 2020, 100:109902. https://doi.org/10.1016/j.pnpbp.2020.109902 5) Su-Ying Cui, Yuan-Li Huang, Xiang-Yu Cui, Hui-Ling Zhao, Xiao Hu, Yu-Tong Liu, Yong-He Zhang*. Serotonergic system may be involved in Alterations of Sleep Homeostasis in Spontaneously Hypertensive Rats. J Sleep Res 2019, 00:e12947. https ://doi.org/10.1111/jsr.12947 6) Xu YP, Cui XY, Liu YT, Cui SY, Zhang YH*. Ginsenoside Rg1 promotes sleep in rats by modulating the noradrenergic system in the locus coeruleus and serotonergic system in the dorsal raphe nucleus. Biomed Pharmacother 2019, 116:109009. doi: 10.1016/j.biopha.2019.109009. 7) Ye H, Cui XY, Ding H, Cui SY, Hu X, Liu YT, Zhao HL, Zhang YH*. Melanin-concentrating hormone (MCH) and MCH-R1 in the locus coeruleus may be involved in the regulation of depressive-like behavior. Int J Neuropsychopharmacol 2018, 21(12):1128-1137. doi: 10.1093/ijnp/pyy088. 8) Cui SY, Song JZ, Cui XY, Hu X, Ma YN, Shi Yu-Tong, Luo Ying, Ge Yan-Ru, Ding H, Ye H, Zhang YH*. Intracerebroventricular streptozotocin-induced Alzheimer’s disease-like sleep disorders in rats: Role of the GABAergic system in the parabrachial complex. CNS Neurosci Ther 2018, 24:1241–1252. https://doi.org/10.1111/cns.13032 9) Ding H, Cui XY, Cui SY*, Ye H, Hu X, Zhao HL, Liu YT, Zhang YH*. Depression-like behaviors induced by chronic corticosterone exposure via drinking water: Time-course analysis. Neurosci Lett 2018;687:202-206. doi:10.1016/j.neulet.2018.09.059. 10) Cui XY, Yang G, Cui SY, Cao Q, Huang YL, Ding H, Ye H, Zhang XQ, Wang ZJ, Zhang YH*. Sleep patterns deteriorate over time in chronic corticosterone- treated rats. Neurosci Lett 2018, 6; 682:74-78. doi: 10.1016/j.neulet.2018.06.017.2.159 11) Song JZ, Cui SY, Cui XY, Hu X, Ma YN, Ding H, Ye H, Zhang YH*. Dysfunction of GABAergic neurons in the parafacial zone mediates sleep disturbances in a streptozotocin-induced rat model of sporadic Alzheimer's disease. Metab Brain Dis 2018, 33(1): 127-137. 12) Yuan-Li Huang, Su-Ying Cui, Xiang-Yu Cui, Qing Cao, Hui Ding, Jin-Zhi Song, Xiao Hu, Hui Ye, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Yong-He Zhang*. Tetrandrine, an alkaloid from S. tetrandra exhibits anti-hypertensive and sleep-enhancing effects in SHR via different mechanisms. Phytomedicine 23 (2016) 1821–1829. 13) Qing Cao, Yong Jiang, Su-Ying Cui, Peng-Fei Tu, Yue-Mei Chen, Xiao-Li Ma, Xiang-Yu Cui, Yuan-Li Huang, Hui Ding, Jin-Zhi Song, Bin Yu, Zhao-Fu Sheng, Zi-Jun Wang, Ya-Ping Xu, Guang Yang, Hui Ye, Xiao Hu, Yong-He Zhang*. Tenuifolin, a saponin derived from Radix Polygalae, exhibits sleep-enhancing effects in mice. Phytomedicine 23 (2016) 1797–1805. 14) Su-Ying Cui • Sheng-Jie Li • Xiang-Yu Cui • Xue-Qiong Zhang • Bin Yu • Zhao-Fu Sheng • Yuan-Li Huang • Qing Cao • Ya-Ping Xu • Zhi-Ge Lin • Guang Yang • Jin-Zhi Song • Hui Ding • Zi-Jun Wang • Yong-He Zhang*. Ca(2+) in the dorsal raphe nucleus promotes wakefulness via endogenous sleep-wake regulating pathway in the rats. Mol Brain. 2016 Jul 26;9(1):71. doi: 10.1186/s13041-016-0252-0. 15) Su-Ying Cui, Sheng-Jie Li, Xiang-Yu Cui, Xue-Qiong Zhang, Bin Yu, Zhao-Fu Sheng, Yuan-Li Huang, Qing Cao, Ya-Ping Xu, Zhi-Ge Lin, Guang Yang, Jin-Zhi Song, Hui Ding, Zi-Jun Wang, Yong-He Zhang*. Phosphorylation of CaMKII in the rat dorsal raphe nucleus plays an important role in sleep-wake regulation. J Neurochem 2016, 136(3):609-619. 16) Bin Yu, Su-Ying Cui, Xue-Qiong Zhang, Xiang-Yu Cui, Sheng-Jie Li, Zhao-Fu Sheng, Qing Cao, Yuan-Li Huang, Ya-Ping Xu, Zhi-Ge Lin, Guang Yang and Yong-He Zhang*. Mechanisms underlying physiological and psychological stress-induced abrupt awakening from posttraumatic “nightmares”. Int J Neuropsychopharmacol 2016, 19(4): 1-6. doi: 10.1093/ijnp/pyv113.015. 17) Bin Yu, Su-Ying Cui, Xue-Qiong Zhang, Xiang-Yu Cui, Sheng-Jie Li, Zhao-Fu Sheng, Qing Cao, Yuan-Li Huang, Ya-Ping Xu, Zhi-Ge Lin, Guang Yang, Jin-Zhi Song, Hui Ding & Yong-He Zhang*. Different neural circuitry is involved in physiological and psychological stress-induced PTSD-like “nightmares” in rats. Sci Rep 2015 DOi: 10.1038/srep15976. 18) Sheng ZF, Cui XY, Cui SY, Yu B, Zhang XQ, Li SJ, Cao Q, Huang YL, Xu YP, Song JZ, Ding H, Lin ZG, Yang G, Zhang YH*. Involvement of adrenoceptors, dopamine receptors and AMPA receptors in antidepressant-like action of 7-O-ethylfangchinoline in mice. Acta Pharmacol Sin 2015, 36(8):949-956. 19) Sheng-Jie Li, Su-Ying Cui, Xue-Qiong Zhang, Bin Yu, Zhao-Fu Sheng, Yuan-Li Huang, Qing Cao, Ya-Ping Xu, Zhi-Ge Lin, Guang Yang, Xiang-Yu Cui, Zhang YH*. PKC in the dorsal raphe nucleus play a key role in sleep-wake regulation. Prog Neuropsychopharmacol Biol Psychiatry 2015, 63:47-53. 20) Wang Zi-Jun ，Zhang Xue-Qiong ，Cui Xiang-Yu，Cui Su-Ying，Yu Bin，Sheng Zhao-Fu，Li Sheng-Jie，Cao Qing，Huang Yuan-Li，Xu Ya-Ping，Zhang YH*. Glucocorticoid receptors in the locus coeruleus mediate sleep disorders caused by repeated corticosterone treatment. Sci Rep 2015, 5: 9442. doi: 10.1038/srep09442.