王维斌 - 北京大学 - 基础医学院

个人简介

(1) 2004-2008：学士，首都医科大学，医学实验学系 (2) 2008-2011：硕士，北京大学医学部，生物化学与分子生物学系 (3) 2011-2014：博士，北京大学医学部，生物化学与分子生物学系 (4) 2014-2019：博士后，耶鲁大学，分子生物物理与生物化学系 (5) 2019-至今：助理教授，北京大学医学部，放射医学系

研究领域

王维斌课题组的主要研究方向是DNA损伤修复与肿瘤。该实验室主要利用生物化学、分子生物学、细胞生物学和模式动物等研究方法，着重研究各种类型DNA损伤的修复机制，及其与基因组不稳定性和肿瘤等疾病的相关 (1) DNA双链断裂损伤的同源重组修复机制与肿瘤发生、肿瘤放化疗 (2) RNA-DNA杂合体/R-loop的调控机制与基因组不稳定性 (3) DNA交联损伤的修复机制与范可尼贫血综合征 (4) 转录与复制冲突的调控机制与肿瘤的相关性

近期论文

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(1) Zhang T, Yang H, Zhou Z, Bai Y, Wang J, Wang W. Crosstalk between SUMOylation and ubiquitylation controls DNA end resection by maintaining MRE11 homeostasis on chromatin. Nature Communications . 2022, in revision (2) Wang W, Daley JM, Kwon Y, Krasner DS, Sung P. Plasticity of the Mre11-Rad50-Xrs2-Sae2 nuclease ensemble in the processing of DNA-bound obstacles. Genes & Development . 2017, 31(23-24): 2331-2336 (3) Bai Y, Wang W, Li S, Zhan J, Li H, Zhao M, Zhou XA, Li S, Li X, Huo Y, Shen Q, Zhou M, Zhang H, Luo J, Sung P, Zhu WG, Xu X, Wang J. C1QBP promotes homologous recombination by stabilizing MRE11 and controlling the assembly and activation of MRE11/RAD50/NBS1 complex. Molecular Cell . 2019, 75(6): 1299-1314 (4) Wang W, Pan K, Chen Y, Huang C, Zhang X. The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression. Nucleic Acids Research . 2012, 40(3): 981-995 (5) Xu Z, Li X, Li H, Nie C, Liu W, Li S, Liu Z, Wang W, Wang J. Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA. Oncogene . 2020, 39(47): 7051-7062 (6) Li H, Wang W, Liu X, Paulson KE, Yee AS, Zhang X. Transcriptional factor HBP1 targets p16INK4A, upregulating its expression and consequently is involved in Ras-induced premature senescence. Oncogene . 2010, 29(36): 5083-5094 (7) Wang W, Daley JM, Kwon Y, Xue X, Krasner DS, Miller AS, Nguyen KA, Williamson EA, Shim EY, Lee SE, Hromas R, Sung P. A DNA nick at Ku-blocked double-strand break ends serves as an entry site for exonuclease 1 (Exo1) or Sgs1-Dna2 in long-range DNA end resection. Journal of Biological Chemistry . 2018, 293(44): 17061-17069 (8) Wang W, Chen Y, Wang S, Hu N, Cao Z, Wang W, Tong T, Zhang X. PIASxalpha ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase. Journal of Biological Chemistry . 2014, 289(6): 3217-3230