王玲 - 北京大学 - 基础医学院

个人简介

1983年毕业于哈尔滨医科大学临床医学专业（医学学士） 1988年毕业于哈尔滨医科大学微生物学专业（医学硕士） 1998年于日本京都大学获得医学博士学位 1999年至2002年在新西兰奥克兰大学分子医学系访问研修 2002年9月至2004年8月在北大医学部师从庄辉院士做博士后研究工作 2004年9月至今在基础医学院病原生物学系任教

研究领域

肝炎病毒分子生物学及致病性研究。主要从事戊型肝炎病毒分子生物学、致病机制及跨种系传播研究；HBV、HEV体外培养体系与抗病毒药物筛选；病毒性肝炎诊断试剂研发等

近期论文

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1. Wang Lin#, Wen Jiexi#, Gao Feng#, Hao Hongjun, Wang Ling*. Hepatitis E virus-associated neurological injury in China. J Infect Dis. 2017. DOI: 10.1093/infdis/jix124.IF=6.34 2. Wang Lin, Xia Junke, Wang Ling*, Wang Youchun*. Experimental infection of rabbits with genotype 3 hepatitis E virus produced both chronicity and kidney injury. Gut. 2017,66(3):561-562.IF=14.921. 3. Wang Lin, Zhang Yulin, Gong Wanyun, Song William Tianshi, Wang Ling*. Hepatitis E virus in 3 types of laboratory animals, China, 2012–2015. Emerg Infect Dis. 2016, 22(12): 2157-2159. IF=7.0. 4. Wang Lin#, Liu Lin#, Wei Yongli, Wang Qianhui, Tian Qing, Wang Ling*, Zhuang Hui. Clinical and virological profiling of sporadic hepatitis E virus infection in China. J Infection. 2016, 73(3): 271-279. IF=4.382. 5. Zhang Yulin, Wang Lin, Zeng Hang, Gong Wanyun, Wang Ling*, Zhuang Hui*. Development and validation of a new serum standard for the measurement of anti-HEV antibodies in animals. J Med Virol. 2017, 89(3):497-501. IF=2.0. 6. Liu Lin, Wang Lin, Xia Junke, Zhang Yulin, Zeng Hang, Liu Peng, Zou Qinghua, Wang Ling*, Zhuang Hui*. Mix-breeding with HEV-infected swine induced inapparent HEV infection in SPF rabbits. J Med Virol. 2016, 88(4):681-685. IF=2.0. 7. Xia Junke, Liu Lin, Wang Lin, Zhang Yulin, Zeng Hang, Liu Peng, Zou Qinghua, Wang Ling* and Zhuang Hui*. Experimental infection of pregnant rabbits with hepatitis E virus demonstrating high mortality and vertical transmission. J Viral Hepat. 2015, 22(10):850-857. IF=4.179. 8. Zhang Yulin,Zeng Hang,Liu Peng,Liu Lin,Xia Junke,Wang Lin,Zou Qinghua,Wang Ling*,Zhuang Hui*. Hepatitis E vaccine immunization for rabbits to prevent animal HEV infection and zoonotic transmission. Vaccine. 2015, 33(38):4922-4928. IF=3.413. 9. Xia Junke, Zeng Hang, Liu Lin, Zhang Yulin, Liu Peng, Geng Jiabao, Wang Lin, Zou Qinghua, Wang Ling*, Zhuang Hui*. Swine and rabbits are the main reservoirs of hepatitis E virus in China: detection of HEV RNA in feces of farmed and wild animals. Archivesof Virology.2015, 160(11):2791-2798. IF=2.255. 10. Han Jian, Zeng Hang, Wang Ling*, Liu Peng, Liu Lin, Xia Junke, Zhang Yulin, Wang Lin, Zhuang Hui. Hepatitis E virus infection in farmed rabbits and swine in the Eastern Chinese city Lianyungang: showing no potential interspecies transmission.J Med Virol. 2014, 86(11):1898-1904. IF=2.0. 11. Liu Peng, Du Renjie, Wang Ling*, Han Jian, Liu Lin, Zhang Yulin, Xia Junke, Lu Fengmin, Zhuang Hui. Management of hepatitis E virus (HEV) zoonotic transmission: protection of rabbits against HEV challenge following immunization with HEV 239 vaccine. PLoS One.2014, 9(1):e87600. IF=3.057. 12. Han Jian, Lei Yaxin, Liu Lin, Liu Peng, Xia Junke, Zhang Yulin, Zeng Hang, Wang Lin, Wang Ling*, Zhuang Hui. SPF rabbits infected with rabbit hepatitis E virus isolate experimentally showing the chronicity of hepatitis.PLoS One. 2014, 9(6):e99861. IF=3.057. 13. Bu Qiuning, Wang Xiaojuan, Wang Ling*, Liu Peng, Geng Jiabao, Wang Maorong, Han Jian, Zhu Yonghong, Zhuang Hui*. Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis. Arch Virol.2013, 158(1):165-172. IF=2.255. 14. Liu Peng#, Bu Qiu-Ning#, Wang Ling*, Han Jian, Du Ren-Jie, Lei Ya-Xin, Ouyang Yu-Qing, Li Jie, Zhu Yong-Hong, Lu Feng-Min, Zhuang Hui. Transmission of hepatitis E virus from rabbits to cynomolgus macaques. Emerg Infect Dis. 2013, 19(4):559-565. IF=7.0. 15. Liu Peng, Li Lingjun, Wang Ling*, Bu Qiuning, Fu Hongwei, Han Jian, Zhu Yonghong, Lu Fengmin, Zhuang Hui*. Phylogenetic analysis of 626 hepatitis E virus (HEV) isolates from humans and animals in China (1986-2011) showing genotype diversity and zoonotic transmission. Infect Genet Evol. 2012,12(2):428-434.IF=2.591. 16. Geng Jiabao, Wang Ling*,Wang Xiaojuan, Fu Hongwei, Bu Qiuning, Zhu Yonghongand Zhuang Hui*. Study on prevalence and genotype of hepatitis E virus isolated from Rex Rabbits in Beijing, China.J ViralHepat.2011, 18(9): 661–667. IF=4.179. 17. Geng Jiabao, Wang Ling*, Wang Xiaojuan, Fu Hongwei, Bu Qiuning, Liu Peng, Zhu Yonghong, Wang Maorong, Sui Yunhuaand Zhuang Hui*. Potential risk of zoonotic transmission from young swine to human: seroepidemiological and genetic characterization of hepatitis E virus in human and various animals in Beijing, China. J ViralHepat.2011, 18(10):e583-90.IF=4.179. 18. Geng Jiabao#, Fu Hongwei#, Wang Ling*, Bu Qiuning, Liu Peng, Wang Maorong, Sui Yunhua, Wang Xiaojuan, Zhu Yonghong, Zhuang Hui*. Phylogenetic analysis of the full genome of rabbit hepatitis E virus (rbHEV) and molecular biologic study on the possibility of cross species transmission of rbHEV. Infect Genet Evol.2011,11(8):2020-2025. IF=2.591.