尹艳慧 - 北京大学 - 基础医学院

个人简介

北京大学医学部免疫学系，副教授。1993年毕业于白求恩医科大学英语医学专业获医学学士学位，1996年于白求恩医科大学免疫教研室获硕士学位，2001年于吉林大学免疫教研室获博士学位，2005年北京大学医学部免疫学系博士后出站。1999至2001年日本德岛大学访问学者。担任中国食品药品监督管理局医疗器械评审专家；担任INT J CAN, SCI REP，Cancer Biology & Medicine等杂志审稿人。获2008年度“北京大学医学部优秀青年学者”称号；作为主要参与人，完成的“新的肿瘤相关抗原的发现及其应用前景研究”，获国家教育部自然科学奖一等奖，中华医学科技奖二等奖，北京市科学技术奖二等奖；三项国内发明专利已获授权；作为主要参与人申请的肿瘤-睾丸抗原NY-ESO-1抗原肽疫苗获得中国FDA批准用于肝癌患者免疫治疗的Ⅰ期临床试验。

研究领域

1.肿瘤的免疫细胞治疗 2.肿瘤抗原在肿瘤微环境形成中的作用及其机制

近期论文

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1. Song X, Guo C, Zheng Y, Wang Y, Jin Z, Yin Y*. Post-transcriptional regulation of cancer/testis antigen MAGEC2 expression by TRIM28 in tumor cells. BMC Cancer. 2018, 18: 971-980. 2. Zeng P, Wang Y, Zheng Y, Song X, Yin Y*. Cancer-testis antigen HCA587/MAGEC2 interacts with the general transcription coactivator TAF9 in cancer cells. Mol Med Rep. 2018; 17: 3226-3231. 3. Song X, Hao J, Wang J, Guo C, Wang Y, He Q, Tang H, Qing X, Li Y, Zhang Y*, Yin Y*. The cancer/testis antigen MAGEC2 promotes amoeboid invasion of tumor cells by enhancing STAT3 signling. Oncogene. 2017; 36, 1476–1486. 4. Wang J#, Song X#, Guo C, Wang Y, Yin Y*. Establishment of MAGEC2-knockout cells and functional investigation of MAGEC2 in tumor cells.Cancer Sci. 2016; 107(12): 1888-1897. 5. Xiao Song#, Wenjie Song#, Ying Wang, Jingjing Wang, Yan Li, Xiaoping Qian, Xuewen Pang, Yu Zhang, Yanhui Yin*. MicroRNA-874 functions as a tumor suppressor by targeting cancer/testis antigen HCA587/MAGE-C2.J Cancer. 2016 ;7(6):656-663.. 6. Hao J, Song X, Wang J, Guo C, Li Y, Li B, Zhang Y*, Yin Y*. Cancer-testis antigen MAGE-C2 binds Rbx1 and inhibits ubiquitin ligase-mediated turnover of cyclin E. Oncotarget. 2015, 6(19):42028-42039. 7. Li X, Peng J, Pang Y, Yu S, Yu X, Chen P, Wang W, Han , Zhang J,Yin Y*, Zhang Y*. Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma. Sci Rep. 2015, 5:14757. 8. Sun X, Jin Z, Song X, Wang J, Li Y, Qian X, Zhang Y, Yin Y*. Evaluation of KF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinoma. BMC Cancer. 2015, 15:961. 9. Jiaqing Hao, Rui Shen, Yan Li, Yu Zhang, Yanhui Yin*. Cancer-testis antigen HCA587/MAGE-C2 interacts with BS69 and promotes its degradation in the ubiquitin-proteasome pathway. Biochem Biophys Res Commun. 2014, 449(4): 386-391. 10. Lijie Zhang, Juanjuan Chen, Xiao Song, Weigang Wen, Yan Li, Yu Zhang, Yanhui Yin*. Cancer/Testis antigen HCA587-derived long peptide vaccine generates potent immunologic responses and antitumor effects in mouse model. Oncol Res. 2014,21(4):193-200.