陈英玉 - 北京大学 - 基础医学院

个人简介

1980.9－1985.7 山东省滨州医学院医疗系学习，获医学学士学位 1990.9－1993.7 北京医科大学免疫学教研室学习，获医学硕士学位 1998.9－2001.7 北京大学基础医学院免疫学系，获得博士学位 2001.7－2003.6 中国科学院动物研究所生物膜与膜工程国家重点实验室，博士后研究工作。 2006.8－2007.7 澳大利亚蒙纳士大学（Monash University）医学院访问学者。 2003.7－至今北京大学基础医学院免疫学系，北京大学人类疾病基因研究中心工作，副教授，教授。

研究领域

1．人类功能基因组学，人类新的细胞凋亡和自噬分子的功能鉴定、分子机制，信号转导通路，及其在肿瘤和自身免疫病中的作用。 2．新的人类功能基因产物单克隆抗体的制备以及ELISA试剂盒等产品的研究开发

近期论文

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Juan xiao, Chen Liu, Ge Li, Jia Hu, Liujing Qu, Yu Zhang, Dalong Ma, Yingyu Chen. PDCD5 negatively regulates autoimmunity by upregulating FOXP3+ regulatory T cells and suppressing Th17 and Th1 responses. JAutoimmunity, 2013, in press.通讯作者） Hong Xie, Jia Hu, Huan Pan, Yaxin Lou, Ping Lv, yingyu chen. Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non–small cell lung cancer cells. BMB Reports. 2013, in press. （通讯作者） Yanjun Li, Yuanbo Zhao, Jia Hu, Juan Xiao, Liujing Qu, Zhenda Wang, Dalong Ma, Yingyu Chen. A novel ER-localized transmembrane protein, EMC6, interacts with RAB5A and regulates cell autophagy.Autophagy. 2013, 9(2):150-63.（通讯作者） Chang Ying, Li Yanjun, Hu Jia, Guo Jinhai, Xu Dong, Xie Hong, Lv Xiaodong, Shi Taiping, Chen Yingyu. Adenovirus vector-mediated expression of TMEM166 inhibits human cancer cell growth by autophagy and apoptosis in vitro and in vivo. Cancer Lett. 2013, 328(1):126-34.（通讯作者） Yuanbo Zhao, Jia Hu, Guangyan Miao, Liujing Qu, Zhenda Wang, Ge Li, Ping Lv, Dalong Ma, Yingyu Chen. Transmembrane Protein 208: A Novel ER-Localized Protein That Regulates Autophagy and ER Stress. PLOS ONE 2013, 8(5):e64228（通讯作者） Chen Yingyu, Zou Zhiqiang, Xu Ailing, Liu Youde, Pan Huan, Jin Lei. Serum programmed cell death protein 5 (PDCD5) levels is upregulated in liver diseases. J Immunoassay Immunochem. 2013, 34(3):294-304.（第一和通讯作者） Li L, Khatibi NH, Hu Q, Yan J, Chen C, Han J, Ma D, Chen Y, Zhou C Transmembrane protein 166 regulates autophagic and apoptotic activities following focal cerebral ischemic injury in rats.Exp Neurol. 2012, 234(1):181-190 (通讯作者) Dong Xu, Fan Yang, Huiying He, Jia Hu, Xiaodong Lv,Dalong Ma, Yingyu Chen , Expression of TMEM166 protein in human normal and tumor tissues. Applied Immunohistochemistry & Molecular Morphology. 2012, Apr 10. [Epub ahead of print] （通讯作者） Yue Lu,Juan Xiao, ZaiWang Wu, ZheMing Wang, Jia Hu, HongZheng Fu, YingYu Chen, RuiQin Qian. Kirenol exerts a potent anti-arthritic effect in collagen-induced arthritis by modifying the T cell balance. Phytomedicine. 2012 Jul 15; 19(10):882-889. (通讯作者) Xu Lanjun, Hu Jing, Zhao Yuanbo, Hu Jia, Xiao Juan, Wang Yanming, Ma Dalong, Chen Yingyu. PDCD5 interacts with p53 and functions as a positive regulator in the p53 pathway. Apoptosis. 2012 Nov; 17(11):1235-45.（通讯作者） Changbao Chen, Hua Zhou,Lanjun Xu, Dong Xu,YingWang, Yingmei Zhang,Xiaoguang Liu,Zhongjun Liu,Dalong Ma, Qingjun Ma, Yingyu Chen.Recombinant human PDCD5 sensitizes chondrosarcomas to cisplatin chemotherapy in vitro and in vivo. Apoptosis, 2010,15:805–813.（通讯作者） Chen Changbao, Zhou Hua,Xu Lanjun, Liu Xiaoguang,Liu Zhongjun,Ma Dalong, Chen Yingyu, Ma Qingjun.Prognostic significance of downregulated expression of programmed cell death 5 in chondrosarcoma. J Surg Oncol. 2010, 102(7):838-843. (共同通讯作者) Lanjun Xu, Yingyu Chen, Quansheng Song, Dong Xu, Ying Wang, Dalong Ma：PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis. Neoplasia, 2009, 11(4): 345-354.（并列第一作者） Hongwei Yao, Lanjun Xu, Yingang Feng, Dongsheng Liu, Yingyu Chen, Jinfeng Wang. Structure-function correlation of human programmed cell death 5 protein. Arch Biochem Biophys. 2009; 486(2):141-149. (共同通讯作者)