韩文玲 - 北京大学 - 基础医学院

个人简介

现任北京大学免疫学系教授，博士生导师，免疫学系副主任，北京大学人类疾病基因研究中心副主任。1998年，韩文玲利用SSH技术开始人类新细胞因子和免疫膜分子研究。在国际上，首次报道了新基因家族CMTM。在人类，该家族包括9个成员，即CKLF和CMTM1-8，在免疫系统、男性生殖系统发挥重要作用，并参与肿瘤的发生、发展。国内、外研究发现CMTM成员定位于网格蛋白包被的囊泡和内体中，调控EGFR、VE-Cadherin、PD-L1等膜分子的转运、降解，其中CMTM6/4稳定PD-L1，是潜在的肿瘤治疗新靶点。2008年，韩文玲与国家人类基因组北方研究中心合作，利用免疫组学技术鉴定新细胞因子和免疫膜分子，发现多个具有重要免疫调控功能的新分子。作为第一作者或责任作者发表SCI论文44篇，包括Cancer Res、Oncogene、J Immunol、Oncoimmunology等；申请发明专利12项。上述成果得到了国际同行验证和拓展，相关文章被Nature、Blood等引用。独立培养博士生20名，联合培养博士生4名，多名学生获北京大学优秀博士论文、北京大学及北京市优秀毕业生等荣誉。 1989年9月-1994年7月，泰山医学院医疗系，获医学学士学位 1994年9月-1999年7月，北京医科大学，导师马大龙教授，获医学博士学位 1999年8月-2001年7月，北京大学医学部，讲师 2001年8月-2006年7月，北京大学医学部，副教授 2006年8月-至今，北京大学医学部，教授

研究领域

新细胞因子和免疫膜分子的功能、机制与应用研究。细胞因子和膜分子介导免疫细胞间相互作用，具有重要的生理功能

近期论文

查看导师最新文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Han W#, Lou Y, Tang J, Zhang Y, Chen Y, Li Y, Gu W, Huang J, Gui L, Tang Y, Li F, Song Q, Di C, Wang L, Shi Q, Sun R, Xia D, Rui M, Tang J, Ma D*. Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity.Biochem J. 2001 Jul 1; 357(Pt 1):127-35. 2. Han W#, Ding P#, Xu M, Wang L, Rui M, Shi S, Liu Y, Zheng Y, Chen Y, Yang T, Ma D*. Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.Genomics. 2003 Jun; 81(6):609-17. 3. Li T, Han W*, Yang T, Ding P, Rui M, Liu D, Wang Y, Ma D. Molecular cloning and identification of mouse Cklfsf2a and Cklfsf2b, two homologues of human CKLFSF2.Int J Biochem Cell Biol. 2006 Mar; 38(3):420-9. 4. Li T, Zhong J, Chen Y, Qiu X, Zhang T, Ma D, Han W*. Expression of chemokine-like factor 1 is upregulated during T lymphocyte activation.Life Sci. 2006 Jul 4; 9(6):519-24. 5. Zhong J, Wang Y, Qiu X, Mo X, Liu Y, Li T, Song Q, Ma D, Han W*. Characterization and expression profile of CMTM3/CKLFSF3.J Biochem Mol Biol. 2006 Sep 30; 39(5):537-45. 6. Wang Y, Li T, Qiu X, Mo X, Zhang Y, Song Q, Ma D, Han W*. CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells. Biochem Biophys Res Commun.2008, Jun 20; 371 (1): 54-8 7. Yu C#,Han W#,Shi T, Lv B, He Q, Zhang Y, Li T, Zhang Y, Song Q, Wang L, Ma D*. PTPIP51, a novel 14-3-3 binding protein, regulates cell morphology and motility via Raf-ERK pathway. Cell Signal. 2008 Dec; 20(12):2208-20. 8. Shao L, Guo X, Plate M, Li T, Wang Y, Ma D, Han W*. CMTM5-v1 induces apoptosis in cervical carcinoma cells.Biochem Biophys Res Commun. 2009 Feb 20; 379 (4):866-71. 9. Wang Y, Li J, Cui Y, Li T, Ng KM, Geng H, Li H, Shu XS, Li H, Liu W, Luo B, Zhang Q, Mok TS, Zheng W, Qiu X, Srivastava G, Yu J, Sung JJ, Chan AT, Ma D, Tao Q*, Han W*. CMTM3, Located at the Critical Tumor Suppressor Locus 16q22.1, is Silenced by CpG Methylation in Carcinomas and Inhibits Tumor Cell Growth through Inducing Apoptosis. Cancer Res 2009; 69: (12), 5194-5201 10. Guo X, Li T, Wang Y, Shao L, Zhang Y, Ma D, Han W*. CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha. Biochem Biophys Res Commun. 2009; 387(1):139-42. 11. Shao L, Li T, Mo X, Majdic O, Zhang Y, Seyerl M, Schrauf C, Ma D, Stöckl J, Han W*. Expressional and functional studies of CKLF1 during dendritic cell maturation. Cell Immunol. 2010; 263(2):188-95. 12. Plate M, Li T, Wang Y, Mo X, Zhang Y, Ma D, Han W*. Identification and characterization of CMTM4, a novel gene with inhibitory effects on HeLa cell growth through inducing G2/M phase accumulation. Mol Cells. 2010 Apr; 29(4):355-61. 13. Li H, Guo X, Shao L, Plate M, Mo X, Wang Y, Han W*.CMTM5-v1, a four-transmembrane protein, presents a secreted form released via a vesicle-mediated secretory pathway. BMB Rep. 2010 Mar; 43(3):182-7. 14. Guo X, Zhang Y, Wang P, Li T, Fu W, Mo X, Shi T, Zhang Z, Chen Y, Ma D, Han W*. VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells. Cell Immunol.2012 Jul; 278(1-2):136-42. 15. Li T, Wang W, Chen Y, Han W*. Preparation and characterization of monoclonal antibodies against VSTM1.Monoclon Antib Immunodiagn Immunother. 2013 Aug; 32(4):283-9. 16. Zhang Y, Wang JY, Han W*. A role for CMTM7 in BCR expression and survival in B-1a but not B-2 cells.Int Immunol. 2014 Jan;26(1):47-57. 17. Su Y, Lin Y, Zhang L, Liu B, Yuan W, Mo X, Wang X, Li H, Xing X, Cheng X, Dong B, Hu Y, Du H, Zhu Y, Ding N, Li J, Liu W, Ma Y, Qiu X, Ji J*, Han W*. CMTM3 inhibits cell migration and invasion and correlates with favorable prognosis in gastric cancer.Cancer Sci. 2014 Jan; 105(1):26-34. 18. Wang X, Wang W, Lin Z, Wang X, Li T, Yu J, Liu W, Tong Z, Xu Y, Zhang J, Guan L, Dai L, Yang Y, Han W*, Li R*.CARD9 mutations linked to subcutaneous phaeohyphomycosis and TH17 cell deficiencies.J Allergy Clin Immunol. 2014 Mar; 133(3):905-8. 19. Li H, Li J, Su Y, Fan Y, Guo X, Li L, Su X, Rong R, Ying J, Mo X, Liu K, Zhang Z, Yang F, Jiang G, Wang J, Zhang Y, Ma D, Tao Q*, Han W*. A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth.Oncogene. 2014 Jun 12; 33(24):3109-18. 20. Pan W, Cheng Y, Zhang H, Liu B, Mo X, Li T, Li L, Cheng X, Zhang L, Ji J, Wang P, Han W*. CSBF/C10orf99, a novel potential cytokine, inhibits colon cancer cell growth through inducing G1 arrest. Sci Rep.2014 Oct 29; 4:6812. 21. Wang W, Li T, Wang X, Yuan W, Cheng Y, Zhang H, Xu E, Zhang Y, Shi S, Ma D, Han W*. FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages.Cell Mol Immunol. 2015 Sep;12(5):615-24. 22. Li T, Guo X, Wang W, Mo X, Wang P, Han W*.V-set and transmembrane domain containing 1 is silenced in human hematopoietic malignancy cell lines with promoter methylation and has inhibitory effects on cell growth.Mol Med Rep. 2015 Feb; 11(2):1344-51. 23. Liang P, Wang X, Wang R, Wan Z, Han W*, Li R*. CARD9 deficiencies linked to impaired neutrophil functions against Phialophora verrucosa.Mycopathologia. 2015 Jun;179(5-6):347-57. 24. Fu W, Cheng Y, Zhang Y, Mo X, Li T, Liu Y, Wang P, Pan W, Chen Y, Xue Y, Ma D, Zhang Y, Han W*. The Secreted Form of Transmembrane Protein 98 Promotes the Differentiation of T Helper 1 Cells.J Interferon Cytokine Res. 2015 Sep;35(9):720-33. 25. Liu H, Wang X, Shi S, Chen Y, Han W*. Efficient production of FAM19A4, a novel potential cytokine, in a stable optimized CHO-S cell system.Protein Expr Purif. 2015 Sep;113:1-7. 26. Li T, Cheng Y, Wang P, Wang W, Hu F, Mo X, Lv H, Xu T*, Han W*. CMTM4 is frequently downregulated and functions as a tumour suppressor in clear cell renal cell carcinoma.J Exp Clin Cancer Res. 2015 Oct 16;34:122. doi: 10.1186/s13046-015-0236-4. 27. Liu B, Su Y, Li T, Yuan W, Mo X, Li H, He Q, Ma D, Han W*. CMTM7 knockdown increases tumorigenicity of human non-small cell lung cancer cells and EGFR-AKT signaling by reducing Rab5 activation.Oncotarget. 2015 Dec 1;6(38):41092-107. 28. Cheng Y, Wang X, Wang P, Li T, Hu F, Liu Q, Yang F, Wang J*, Xu T*, Han W*. SUSD2 is frequently downregulated and functions as a tumor suppressor in RCC and lung cancer.Tumour Biol. 2016 Jan 27. 29.Liu H, Zou X, Li T, Wang X, Yuan W, Chen Y, Han W*. Enhanced production of secretory glycoprotein VSTM1-v2 with mouse IgGκ signal peptide in optimized HEK293F transient transfection.J Biosci Bioeng. 2016 Feb;121(2):133-9. 30. Wang X, Liu H, Yuan W, Cheng Y, Han W*. Efficient production of CYTL1 protein using mouse IgGκ signal peptide in the CHO cell expression system.Acta Biochim Biophys Sin. 2016 Feb 27. 31. Wang X, Li T, Wang W, Yuan W, Liu H, Cheng Y, Wang P, Zhang Y, Han W*. Cytokine like-1 Chemoattracts Monocytes/Macrophages via CCR2. J Immunol. 2016 May 15;196 (10):4090-9. 32. Yuan W, Li T, Mo X, Wang X, Liu B, Wang W, Su Y, Xu L, Han W*. et al. Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway. Oncotarget. 2016 May 17;7(20):29507-19. 33. Yuan W, Liu B, Wang X, Li T, Xue H, Mo X, Yang S, Ding S*, Han W*.CMTM3 decreases EGFR expression and EGF-mediated tumorigenicity by promoting Rab5 activity in gastric cancer. Cancer Lett. 2017 Feb 1; 386:77-86. 34. Liu H, Zhang Y, Liu Z, Wang P, Mo X, Fu W, Liu W, Cheng Y, Han W*.LYG1 exerts antitumor function through promoting the activation, proliferation, and function of CD4+ T cells.Oncoimmunology. 2017 Mar 7;6(4):e1292195. 35. Li T, Wang W, Cheng Y, Han W*.Method for quantitative detection of FAM19A4 by flow cytometry using latex beads as solid carrier.J Biosci Bioeng. 2018 Mar;125(3):359-364. 36. Zhang K, Shi S, Han W*. Research progress in cytokines with chemokine-like function. Cell Mol Immunol. 2018 Jul;15(7):660-662.Review. 37. Liu W, Li T, Wang P, Liu W, Liu F, Mo X, Liu Z, Song Q, Lv P, Ruan G, Han W*. LRRC25 plays a key role in all-trans retinoic acid-induced granulocytic differentiation as a novel potential leukocyte differentiation antigen.Protein Cell. 2018 Sep;9(9):785-798. 38. Wang X, Li T, Cheng Y, Wang P, Yuan W, Liu Q, Yang F, Liu Q, Ma D, Ding S*, Wang J*, Han W*. CYTL1 inhibits tumor metastasis with decreasing STAT3 phosphorylation. Oncoimmunology. 2019 Feb 18;8(5):e1577126. 39. Liu F, Liu X, Liu X, Li T, Zhu P, Liu Z, Xue H, Wang W, Yang X, Liu J, Han W*. Integrated Analyses of Phenotype and Quantitative Proteome of CMTM4 Deficient Mice Reveal Its Association with Male Fertility.Mol Cell Proteomics. 2019 Jun;18(6):1070-1 40. Xue H, Li T, Wang P, Mo X, Zhang H, Ding S, Ma D, Lv W*, Zhang J*, Han W*. CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2, and STAT3 pathway in colorectal cancer.Acta Biochim Biophys Sin (Shanghai). 2019 Sep 6;51(9):915-924. 41. Liu Z, Liu Y, Li T, Wang P, Mo X, Lv P, Ge Q, Ma D, Han W*. Cmtm7 knockout inhibits B-1a cell development at the transitional (TrB-1a) stage.Int Immunol. 2019 Oct 16;31(11):715-728. 42. Liu Z, Liu Y, Li T, Wang P, Mo X, Lv P, Ma D, Han W*. CMTM7 plays key roles in TLR-induced plasma cell differentiation and p38 activation in murine B-1 B cells. Eur J Immunol. 2020 Jun;50(6):809-821. 43. Liu Z, Liu Y, Li T, Wang P, Mo X, Lv P, Ma D, Han W*. Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells. Cell Immunol. 2020 Jun;352:104100. 44. Deng W, Su Z, Liang P, Ma Y, Liu Y, Zhang K, Zhang Y, Liang T, Shao J, Liu X, Han W*, Li R*. Single-cell immune checkpoint landscape of PBMCs stimulated with Candida albicans. Emerg Microbes Infect. 2021 Dec;10(1):1272-1283.