个人简介
2018—至今 副研究员（Tenure track）：北京大学医学部精准医疗多组学研究中心（副主任）／基础医学院
2016—2018 副研究员：清华大学生命科学学院
2014—2016 助理研究员：清华大学生命科学学院
2012—2014 博士后：清华大学生命科学学院（合作导师：俞立）
2008—2012 博士：北京大学医学部基础医学专业（美国国立卫生研究院）
（导师：柯杨、Matthias Machner）
2004—2008 本科：北京大学医学部基础医学专业
研究领域
主要从事膜性细胞结构和细胞器生物膜动态变化的研究。研究外泌体、新细胞器迁移体等细胞外囊泡发生、物质分选运输、细胞间信号沟通的分子细胞生物学机制。应用蛋白质谱技术定量鉴定疾病样品中迁移体、外泌体的内容物，探索细胞外囊泡在疾病中的重要作用及疾病诊断中的功能。
近期论文
查看导师最新文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
1. Yang Chen*, Nan Zhang*, Jie Zhang*, Jiangtao Guo*, Shaobo Dong*,Heqiang Sun, Shuaixin Gao, Tingting Zhou, Min Li, Xueyuan Liu, Yaxin Guo, Beiwei Ye, Yingze Zhao, Tongqi Yu, Jianbo Zhan, Yongzhong Jiang,Catherine CL Wong#, George F. Gao#, William J. Liu#. Immune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19. Biochimica et Biophhysica Acta proteins and proteomics . 2022 Feb 1; 1870(2): 140736. Epub ahead of print. ( Cover story )
2. Wenmin Tian*, Delin Li*, Nan Zhang*, Guijie Bai, Kai Yuan, Haixia Xiao, Feng Gao, Yang Chen#, Catherine C L Wong#, George Fu Gao#. O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an "O-Follow-N" rule. Cell Research . 2021 Oct;31(10):1123-1125.
3. Yang Chen*, Hangping Yao*, Nan Zhang*, Jie Wu*, Shuaixin Gao, Jiangtao Guo, Xiangyun Lu, Linfang Cheng, Rui Luo, Xue Liang, Catherine CL Wong#, Min Zheng#. Proteomic analysis identifies prolonged disturbances in pathways related to cholesterol metabolism and myocardium function in the COVID-19 recovery stage. The Journal of Proteome Research . 2021 Jul 2;20(7):3463-3474
4. Wenmin Tian*, Nan Zhang*, Ronghua Jin*, Yingmei Feng*, Siyuan Wang*, Shuaixin Gao, Ruqin Gao, Guizhen Wu, Wenjie Tan*, Yang Chen#, George, Fu Gao#, and Catherine CL Wong#(corresponding author). Immune suppression in the early stage of COVID-19 disease. Nature Communications . 2020, 11(1):5859.
5. Puzhong Lu, Rui Liu, Di Lu, Yue Xu, Xueyi Yang, Zheng Jiang, Chun Yang, Li Yu#, Xiaoguang Lei#, Yang Chen# (2020). Chemical screening identifies ROCK1 as a regulator of migrasome formation. Cell Discovery , 2020 Aug 4;6:51.
6. Xiaoxin Zhao*, Yaxin Lei, Jiajia Zheng, Junya Peng, Ying Li, Li Yu#, and Yang Chen# (2019). Identification of markers for migrasome detection. Cell Discovery , 2019 May 21;5:27. (co-corresponding author)
7. Mi N*, Chen Y*, Wang S, Chen M, Zhao M, Yang G, Ma M, Su Q, Luo S, Shi J, Xu J, Guo Q, Gao N, Sun Y, Chen Z, Yu L. CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nature Cell Biology . 2015 Jan; 25(1): 24-38 (co-first author)
8. Du W*, Su QP*, Chen Y*, Zhu Y, Jiang D, Rong Y, Zhang S, Zhang Y, Ren H, Zhang C, Wang X, Gao N, Wang Y, Sun L, Sun Y, Yu L. Kinesin 1 Drives Autolysosome Tubulation. Developmental Cell . 2016 May 23; 37(4): 326-36 (co-first author)
9. Neunuebel MR*, Chen Y*, Gaspar AH, Backlund PS Jr, Yergey A, Machner MP. De-AMPylation of the small GTPase Rab1 by the pathogen Legionella pneumophila. Science . 2011 Jul 22; 333(6041): 453-6 (co-first author)
10. Chen Y*, Tascón I*, Neunuebel MR, Pallara C, Brady J, Kinch LN, Fernández-Recio J, Rojas AL, Machner MP, Hierro A. Structural basis for Rab1 de-AMPylation by the Legionella pneumophila effector SidD. PLOS Pathogen . 2013 May 16; (co-first author)
11. Chen Y*, Machner MP. Targeting of the small GTPase Rab6A' by the Legionella pneumophila effector LidA. Infection and Immunity . 2013 Jun 881(6): 2226-35
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