尚永丰 - 首都医科大学

个人简介

2003年获国家自然基金委“杰出青年基金”，2007年担任国家自然科学基金委“创新研究群体”带头人，2009年入选人社部工程国家级人选，2010年享受国务院政府特殊津贴，2009年当选为中国科学院院士。

研究领域

主要从事基因转录调控的表观遗传机制和乳腺癌/子宫内膜癌发生发展的分子机理的研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1.Xia Yi, Mei Hong, Bing Gui, Zhe Chen, Lei Li, Guojia Xie, Jing Liang, Wang X, Shang Y* (2012). RNA processing and modification protein, carbon catabolite repression 4 (Ccr4), arrests the cell cycle through p21-dependent and p53-independent pathway. The Journal of Biological Chemistry 287(25):21045-57 2.Dandan Wang, Jing Liang, Yu Zhang, Bin Gui, Feng Wang, Xia Yi, Luyang Sun, Zhi Yao, Yongfeng Shang* (2012). Steroid Receptor Coactivator-interacting Protein (SIP) Inhibits Caspase-independent Apoptosis by Preventing Apoptosis-inducing Factor (AIF) from Being Released from Mitochondria. The Journal of Biological Chemistry 287(16): 12612-21 3.Fen Yang, Luyang Sun, Qian Li, Xiao Han, Liandi Lei, Hua Zhang*, and Yongfeng Shang* (2012). SET8 promotes epithelial-mesenchymal transition and confers Twist dual transcriptional activities. The EMBO Journal 31: 110-23 4.Xiaohan Yang, Wenhua Yu, Lei Shi, Luyang Sun, Jing Liang, Xia Yi, Qian Li, Yu Zhang, Fen Yang, Xiao Han, Di Zhang, Jie Yang, Zhi Yao, and Yongfeng Shang* (2011). HAT4, a Golgi Apparatus-anchored B-type Histone Acetyltransferase, Acetylates Free Histone H4 and Facilitates Chromatin Assembly. Molecular Cell 44: 39-50 5.Qian Li, Lei Shi, Bin Gui, Wenhua Yu, Jiamu Wang, Di Zhang, Xiao Han, Zhi Yao, and Yongfeng Shang* (2011). Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. Cancer Research 71: 6899-908 6.Lei Shi, Luyang Sun, Qian Li, Jing Liang, Wenhua Yu, Xia Yi, Xiaohan Yang, Yanyan Li, Xiao Han, Yu Zhang, Chenghao Xuan, Zhi Yao, and Yongfeng Shang* (2011). Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci U S A. 108: 7541-7546 7.Yanyan Li, Luyang Sun, Yu Zhang, Dandan Wang, Feng Wang, Jing Liang, Bin Gui, and Yongfeng Shang* (2011). The histone modifications governing TFF1 transcription mediated by estrogen receptor The Journal of Biological Chemistry 286: 13925-13936 8.Luyang Sun, Lei Shi, Feng Wang, Peiwei Huangyang, Wenzhe Si, Jie Yang, Zhi Yao*, and Yongfeng Shang* (2011). Substrate Phosphorylation and Feedback Regulation in JFK-promoted p53 Destabilization. The Journal of Biological Chemistry 286: 4226-4235 9.Yu Zhang, Jing Liang, Yanyan Li, Chenghao Xuan, Feng Wang, Dandan Wang, Lei Shi, Di Zhang, and Yongfeng Shang* (2010). CCCTC-binding Factor Acts Upstream of FOXA1 and Demarcates the Genomic Response to Estrogen. The Journal of Biological Chemistry 285: 28604–28613 10.Wenhua Yu, Ruifang Li, Bin Gui, and Yongfeng Shang* (2010). sZIP, an Alternative Splice Variant of ZIP, Antagonizes Transcription Repression and Growth Inhibition by ZIP. Journal of Biological Chemistry 285: 14301-14307 11.Yan Wang, Hua Zhang, Yupeng Chen, Yimin Sun, Fen Yang, Wenhua Yu, Jing Liang, Luyang Sun, Xiaohan Yang, Lei Shi, Ruifang Li, Qian Li, Xia Yi, and Yongfeng Shang* (2009). LSD1 is a Subunit of the NuRD complex and Targets the Metastasis Programmes in Breast Cancer. Cell 138: 660-672