王韵 - 北京大学 - 基础医学院

个人简介

教育经历 1. 1984.9~1989.6，江西医学院医疗系临床专业，于1989.6获医学学士学位 2. 1989.9~1992.6，北京医科大学生理系，于1992.6获医学硕士学位 3. 1993.9~1996.6，北京医科大学生理系，于1996.6获医学博士学位工作经历 1. 1992.8~1993.9，北京医科大学生理系消化研究室，助教 2. 1993.9~1998.12，北京医科大学生理系神经科学研究中心，讲师 3. 1999.1~2004.8，北京大学神经科学研究所，讲师，副教授 4. 2004.8~至今，北京大学神经科学研究所，教授 5. 2000.12~2002.12，美国国立卫生研究院（NIH），访问学者

研究领域

我们课题组主要从事神经系统细胞信号转导的研究。综合利用多学科手段，整合分子生物学、生物化学、遗传学、电生理学、形态学和行为学等方法

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Sun ZW, Waybright JM, Beldar S, Chen L, Foley CA, Norris-Drouin JL, Lyu TJ, Dong A, Min J, Wang YP, James LICA, Wang YCA. Cdyl deficiency brakes neuronal excitability and nociception through promoting Kcnb1 transcription in peripheral sensory neurons. Adv Sci (Weinh). 2022 Feb 4:e2104317. doi: 10.1002/advs.202104317. Online ahead of print.PMID: 35119221. 2. Wang F, Yin XS, Lu J, Cen CCA and Wang YCA. Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory. Sci Signal. 2022 Feb;15(719):eabd0033. doi: 10.1126/scisignal.abd0033. Epub 2022 Feb 1. 3. Liu L, Liu TT, Xie GG, Zhu XQ, Wang YCA. Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating degradation of the epigenetic factor CDYL. FASEB J. 2022 Jan;36(1):e22087. doi: 10.1096/fj.202100031RR.PMID: 34888944 4. Dong C, Liu Y, Lyu TJ, Beldar S, Lamb KN, Tempel W, Li Y, Li Z, James LI, Qin SCA, Wang YCA, Min JCA. Structural Basis for the Binding Selectivity of Human CDY Chromodomains. Cell Chem Biol. 2020 Jul 16;27(7):827-838.e7. doi: 10.1016/j.chembiol.2020.05.007. Epub 2020 May 28. 5. Liu H, Su D, Liu L, Chen L, Zhao Y, Chan SO, Zhang W, Wang YCA, Wang JCA. Identification of a new functional domain of Nogo-A that promotes inflammatory pain and inhibits neurite growth through binding to NgR1. FASEB J. 2020 Jun 29. doi: 10.1096/fj.202000377R. Online ahead of print. 6. Huang S, Zheng C, Xie G, Song Z, Wang P, Bai Y, Chen D, Zhang Y, Lv P, Liang W, She S, Li Q, Liu Z, Wang Y, Xing GGCA, Wang YCA. FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice. Mol Psychiatry. 2020 Apr 21. doi: 10.1038/s41380-020-0720-x. Online ahead of print. 7. Yin XS, Yang JY, Cao S, Wang YCA. Failure of Placebo Analgesia Model in Rats with Inflammatory Pain. Neurosci Bull. 2020 Feb;36(2):121-133. doi: 10.1007/s12264-019-00420-6. Epub 2019 Aug 21. 8. Li WQ, Luo LD, Hu ZW, Lyu TJ, Cen C, Wang YCA. PLD1 promotes dendritic spine morphogenesis via activating PKD1. Mol Cell Neurosci. 2019 Sep;99:103394. doi: 10.1016/j.mcn.2019.103394. Epub 2019 Jul 26. 9. Liu J, Du J, Wang YCA. CDK5 inhibits the clathrin-dependent internalization of TRPV1 by phosphorylating the clathrin adaptor protein AP2μ2. Sci Signal. 2019 Jun 11;12(585). pii: eaaw2040. doi: 10.1126/scisignal.aaw2040. 10. Xu Y, Tian NX, Bai QY, Chen Q, Sun XH, Wang YCA. Gait Assessment of Pain and Analgesics: Comparison of the DigiGait™ and CatWalk™ Gait Imaging Systems. Neurosci Bull. 2019 Jun;35(3):401-418. doi: 10.1007/s12264-018-00331-y. Epub 2019 Jan 18. 11. Hu F, Liu HC, Su DQ, Chen HJ, Chan SO, Wang YCA, Wang JCA. Nogo-A promotes inflammatory heat hyperalgesia by maintaining TRPV-1 function in the rat dorsal root ganglion neuron. FASEB J . 2019 Jan;33(1):668-682. doi: 10.1096/fj.201800382RR. Epub 2018 Jul 19. PMID:30024789 12. Guo YP, Zhi YR, Liu TT, Wang Y, Zhang YCA. Global Gene Knockout of Kcnip3 Enhances Pain Sensitivity and Exacerbates Negative Emotions in Rats. Front Mol Neurosci. 2019 Jan 25;12:5. doi: 10.3389/fnmol.2019.00005. eCollection 2019. PMID: 30740043 13. Duo L, Hu L, Tian N, Cheng G, Wang H, Lin Z, Wang YCA, Yang YCA. TRPV1 gain-of-function mutation impairs pain and itch sensations in mice. Mol Pain. 2018 Jan-Dec;14:1744806918762031. doi: 10.1177/1744806918762031. Epub 2018 Feb 9. 14. Tian NX, Xu Y, Yang JY, Li L, Sun XH, Wang YCA and Zhang YCA. KChIP3 N-terminal 31-50 fragment mediates its association with TRPV1 and alleviates inflammatory hyperalgesia in rats. J Neurosci. 2018 Jan 15. pii: 2242-17. doi: 10.1523/JNEUROSCI.2242-17.2018. [Epub ahead of print] PMID: 29335353. 15. Cen C, Luo LD, Li WQ, Li G, Tian NX, Zheng G, Yin DM, Zou YM, Wang YCA. PKD1 promotes functional synapse formation coordinated with N-cadherin in hippocampus. J Neurosci. 2018 Jan 3; 38(1):183-199. 16. Luo LD, Li G, Wang YCA. PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage. Scientific Reports. 2017 Jul 20; 7(1):6035. doi: 10.1038/s41598-017-06121-2. 17. Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang YCA, Zhang YCA. Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors. Exp Neurol. 2017 Sep;295:66-76. doi: 10.1016/j.expneurol.2017.05.001. Epub 2017 May 4. 18. Qin R, Cao S, Lyu T, Qi C, Zhang W, Wang YCA. CDYL Deficiency Disrupts Neuronal Migration and Increases Susceptibility to Epilepsy. Cell Rep. 2017 Jan 10;18(2):380-390. doi: 10.1016/j.celrep.2016.12.043. 19. Zhang C, Lu J, Liu B, Cui QCA, Wang YCA. Primate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease. Aging (Albany NY). 2016 Feb;8(2):272-90. 20. Liu J, Du J, Yang Y, Wang YCA. Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia. Exp Neurol. 2015 Nov;273:253-62. doi: 10.1016/j.expneurol.2015.09.005. Epub 2015 Sep 12. 21. Wang Y. FXYD2: a promising drug target for inflammatory mechanical pain therapy. Science Bulletin 2015, 60(9):896-898. (Research Highlight ) 22. Wang GQ, Cen C, Cao S, Li C, Wang N, Zhou Z, Liu XM, Xu Y, Tian NX, Zhang Y, Wang J, Wang LPCA and Wang YCA. Deactivation of excitatory neurons in the contralateral prelimbic cortex via Cdk5 promotes pain sensation and anxiety. Nat Commun. 2015, Jul 16; 6: 7660. doi: 10.1038/ncomms8660. 23. Zhang Y, Wang N, Su P, Lu J, Wang YCA. Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice. Neurosci Bull. 2014, 30(6):1025-35. 24. Li Y, Hu F, Chen HJ, Du YJ, Xie ZY, Zhang Y, Wang JCA, Wang YCA. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Sci Signal. 2014 Jun 24;7(331):ra61. doi: 10.1126/scisignal.2005353. 25. Wang N, Su P, Zhang Y, Lu J, Xing BM, Kang K, Li WQ, Wang YCA. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacol. 2014, 39(5):1290-301. 26. Qi C, Liu SM, Qin R, Zhang Y, Wang GQ, Shang, YF, Wang YCA and Liang JCA. Coordinated Regulation of Dendrite Arborization by Epigenetic Factors CDYL and EZH2. J Neurosci. 2014 March 26;34(13):4494-508. 27. Li G, Wang YCA. Protein kinase D: a new player among the signaling proteins that regulate functions in the nervous system. Neurosci Bull. 2014 Jun;30(3):497-504. doi: 10.1007/s12264-013-1403-2. Epub 2014 Feb 13.